BIOLOGICAL EVALUATION OF GLYCOGEN SYNTHASE KINASE-3 Β INHIBITORS AS ANTIDIABETIC AGENT
Keywords:Phenylmethylenehydantoin, Phenylmethylenerhodanine, Antidiabetic, GSK-3β
A series of phenylmethylenehydantoin and phenylmethylenerhodanine derivatives (Der 1 to
Der 8) were synthesized. These newly synthesized derivatives have been characterized by
elemental analysis molecular weight measurements as well as spectral (IR, 1H NMR
13CNMR) studies. All the compounds show significant increase in liver glycogen level at 25
mg/kg dose levels, in- vivo & these compounds were also screened for anti diabetic activity on
albino rats. Most of these compounds have shown significant antidiabetic activity at 25 mg/kg
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