ANTIMICROBIAL AND ANTICANCER ACTIVITIES OF HYDRAZINE DERIVATIVES AND THEIR METAL COMPLEXES: A COMPARATIVE STUDY
DOI:
https://doi.org/10.29121/shodhkosh.v5.i6.2024.5480Keywords:
Hydrazine Derivatives, Metal Complexes, Antimicrobial Activity, Anticancer Activity, Cytotoxicity, Drug Development, Spectroscopic Characterization, BioavailabilityAbstract [English]
Derivatives of hydrazine and their metal complexes turned out to be compounds of intense interest in pharmaceutical and medicinal chemistry due to their potential antimicrobial and anticancer activities . Herein, however, we aim to discuss ranged biological profile in free hydrazine derivatives compared to their metal complexes with an emphasize on the influence of metals coordination on pharmacological effects. The agar well diffusion method was used to test for antimicrobial activity against bacterial (E. coli, S. aureus) and fungal (C. albicans, A. niger) strains. Anticancer activityEva was evaluated against human breast cancer (MCF-7) and lung cancer (A549) cell lines by MTT assay. Structural characterization was performed using spectroscopic techniques such as UV-Vis, IR, and NMR. Metals regarding anticancer activity were much more effective than free hydrazine derivatives, due to enhanced stability, bioavailability, and targeted interaction with biomolecules. Thus, this comparative study suggests the therapeutic potential of hydrazine-based metal complexes that could lead to drug development. Future studies must focus on in vivo confirmation and clinical applicability.
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