A COMPREHENSIVE REVIEW OF NEUROBIOLOGICAL MECHANISMS DRIVING THE EFFECTS OF YOGA ON MENTAL HEALTH
DOI:
https://doi.org/10.29121/shodhkosh.v5.i3.2024.5246Keywords:
Contemplative Neuroscience, Emotional Resilience, Meditation, Mental Health, YogaAbstract [English]
Yoga has been found to promote positive changes in brain function strengthening areas that help regulate emotions and decision-making while also improving the balance of chemicals that contribute to mood stability. The practice encourages relaxation and helps the body shift into a calmer state reducing stress and anxiety through mindful breathing and exercises. Additionally, yoga supports the body's natural ability to manage stress by lowering excessive levels of stress hormones and fostering a more balanced physiological response. It also plays a key role in sharpening mental focus and breaking cycles of negative thought patterns helping individuals develop greater clarity and emotional resilience. The benefits of yoga extend to various mental health conditions that include anxiety, depression, and trauma-related disorders providing an accessible and holistic approach to psychological well-being. Furthermore, yoga's influence on brain health contributes to long-term emotional stability, supporting mental clarity and helping maintain cognitive sharpness over time. This study explores the growing understanding of how yoga influences mental health and the underlying mechanisms that explain how yoga enhances emotional well-being, cognitive function, and is effective in overall stress management. The interconnected effects of yoga on multiple neurobiological systems suggest its utility in preventive mental health care, facilitating emotional stability, stress adaptability, and optimized cognitive performance.
References
Aggarwal, A. (2020). Hypothalamo-pituitary-adrenal axis and brain during stress, yoga and meditation. International Journal of Health and Clinical Research, 3(9), 96-103.
Akella, K., Kanuri, S. H., Murtaza, G., Della Rocca, D. G., Kodwani, N., Turagam, M. K., & Lakkireddy, D. (2020). Impact of yoga on cardiac autonomic function and arrhythmias. Journal of atrial fibrillation, 13(1), 2408. DOI: https://doi.org/10.4022/jafib.2408
Arora, R., Verma, H., Banumathy, N., & Sharma, M. (2024). The Regulation of Neuro-immune System by Pi (Parasympathetic) and SiGMA (Sympathetic Induction Governed by Meditation and Asana) Rhythmicity. In Neuroscience of Yoga: Theory and Practice: Part 1, Singapore: Springer Nature Singapore, 17-36. DOI: https://doi.org/10.1007/978-981-97-2851-0_2
Arora, S., & Bhattacharjee, J. (2008). Modulation of immune responses in stress by Yoga. International journal of yoga, 1(2), 45-55. DOI: https://doi.org/10.4103/0973-6131.43541
Bakshi, K., & Srivastava, V. (2024). Neurobiology of Yoga and Mindfulness and Its Impact on Neuronal Function, Wellbeing Addiction, and Palliative Care. In Neuroscience of Yoga: Theory and Practice: Part 1, Singapore: Springer Nature Singapore, 37-60. DOI: https://doi.org/10.1007/978-981-97-2851-0_3
Barua, R. (2025). Harmonizing Body and Mind: Investigating the Combined Impact of Yoga and Mindfulness Meditation on Depression, Anxiety, Stress. In Global Innovations in Physical Education and Health, IGI Global, 203-232. DOI: https://doi.org/10.4018/979-8-3693-3952-7.ch008
Bhatt, D., Kashyap, K., Chandravanshi, J., & Kumar, A. (2024). Exercise, Yoga and Meditation Positive Impact on those Suffering from Depression and Anxiety Disorders. European Journal of Cardiovascular Medicine, 14(2).
Campelo, G., de Araújo, J. R., Aristizabal, J. P., de Souza, W., & de Castilho, G. M. (2025). Long-term effects of yoga-based practices on neural, cognitive, psychological, and physiological outcomes in adults: a scoping review and evidence map. BMC complementary medicine and therapies, 25(1), 92. DOI: https://doi.org/10.1186/s12906-025-04825-x
Chand, R., & Sazima, G. (2024). The Science of Mindfulness: Research and Benefits. In Mindfulness in Medicine: A Comprehensive Guide for Healthcare Professionals, Springer Nature Switzerland, 27-58. DOI: https://doi.org/10.1007/978-3-031-66166-2_3
Clemente-Suárez, V. J., Martín-Rodríguez, A., Curiel-Regueros, A., Rubio-Zarapuz, A., & Tornero-Aguilera, J. F. (2025). Neuro-Nutrition and Exercise Synergy: Exploring the Bioengineering of Cognitive Enhancement and Mental Health Optimization. Bioengineering, 12(2), 208. DOI: https://doi.org/10.3390/bioengineering12020208
Diamond, D., & Aitken, M. E. (2013). Yoga: The art of transformation. Smithsonian Books.
Fialoke, S., Tripathi, V., Thakral, S., Dhawan, A., Majahan, V., & Garg, R. (2024). Functional connectivity changes in meditators and novices during yoga nidra practice. Scientific Reports, 14(1), 12957. DOI: https://doi.org/10.1038/s41598-024-63765-7
Froeliger, B., Garland, E. L., & McClernon, F. J. (2012). Yoga Meditation Practitioners Exhibit Greater Gray Matter Volume and Fewer Reported Cognitive Failures: Results of a Preliminary Voxel‐Based Morphometric Analysis. Evidence‐Based Complementary and Alternative Medicine, 2012(1), 821307. DOI: https://doi.org/10.1155/2012/821307
Gangenahalli, G., Chander, V., Verma, Y. K., & Singh, S. (2024). The Impact of Yoga, Pranayama, and Mindfulness Training on Neurocognitive, Neurophysiological, and Neuropsychological Changes in High Altitude. In Neuroscience of Yoga: Theory and Practice, Springer, (1)157-184. DOI: https://doi.org/10.1007/978-981-97-2851-0_10
Gard, T., Noggle, J. J., Park, C. L., Vago, D. R., & Wilson, A. (2014). Potential self-regulatory mechanisms of yoga for psychological health. Frontiers in human neuroscience, 8, 770. DOI: https://doi.org/10.3389/fnhum.2014.00770
Gaur, S., Panjwani, U., & Kumar, B. (2020). EEG Brain Wave Dynamics: A Systematic Review and Meta Analysis on Eff ect of Yoga on Mind Relaxation. Journal of Biomedical Research & Environmental Sciences, 1(7), 353-362. DOI: https://doi.org/10.37871/jbres1166
Gerbarg, P. L., & Brown, R. P. (2015). Yoga and neuronal pathways to enhance stress response, emotion regulation, bonding, and spirituality. In Yoga Therapy, Routledge, 49-64.
Gothe, N. P., Khan, I., Hayes, J., Erlenbach, E., & Damoiseaux, J. S. (2019). Yoga effects on brain health: a systematic review of the current literature. Brain Plasticity, 5(1), 105-122. DOI: https://doi.org/10.3233/BPL-190084
Hendriks, T., De Jong, J., & Cramer, H. (2017). The effects of yoga on positive mental health among healthy adults: a systematic review and meta-analysis. The Journal of Alternative and Complementary Medicine, 23(7), 505-517. DOI: https://doi.org/10.1089/acm.2016.0334
Jayantilal, P. K., & Kashyap, A. (2024). The Role of Yoga in Enhancing Decision Making: A Research Perspective. Journal of Ayurveda and Integrated Medical Sciences, 9(8), 177-183. DOI: https://doi.org/10.21760/jaims.9.8.27
Joseph, M. C., Kammath, S. P., & Fincy, M. P. (2019). Yoga and emotional intelligence. IAHRW International Journal of Social Sciences Review, 7(6).
Khajuria, A., Kumar, A., Joshi, D., & Kumaran, S. S. (2023). Reducing stress with yoga: A systematic review based on multimodal biosignals. International journal of yoga, 16(3), 156-170. DOI: https://doi.org/10.4103/ijoy.ijoy_218_23
Kinser, P. A., Goehler, L. E., & Taylor, A. G. (2012). How might yoga help depression? A neurobiological perspective. Explore, 8(2), 118-126. DOI: https://doi.org/10.1016/j.explore.2011.12.005
Kora, P., Meenakshi, K., Swaraja, K., Rajani, A., & Raju, M. S. (2021). EEG based interpretation of human brain activity during yoga and meditation using machine learning: A systematic review. Complementary therapies in clinical practice, 43, 101329. DOI: https://doi.org/10.1016/j.ctcp.2021.101329
Krause-Sorio, B., Siddarth, P., Kilpatrick, L., Milillo, M. M., Aguilar-Faustino, Y., Ercoli, L., & Lavretsky, H. (2022). Yoga prevents gray matter atrophy in women at risk for Alzheimer’s disease: A randomized controlled trial. Journal of Alzheimer’s Disease, 87(2), 569-581. DOI: https://doi.org/10.3233/JAD-215563
Krishnakumar, D., Hamblin, M. R., & Lakshmanan, S. (2015). Meditation and yoga can modulate brain mechanisms that affect behavior and anxiety-A modern scientific perspective. Ancient science, 2(1), 13. DOI: https://doi.org/10.14259/as.v2i1.171
Kumari, S., Nadholta, P., Dahiya, N., Sharma, A., Singh, H., Kumar, S., & Singh, G. (2024). Link between Yoga and Heart Rate Variability: Can Yoga Enhance the Cardiac Resonance. International Journal of Yoga, 17(2), 67-75. DOI: https://doi.org/10.4103/ijoy.ijoy_50_24
Lamba, P., Deepti D., Navpreet M., Harminder K., Sunil K. C., Pragyasgaa C., and Nimapreet K. (2023). "Effect of Surya Namaskar on Autonomic Status and Serum Cortisol Levels in Male Medical Students: A Longitudinal Study." Journal of Clinical & Diagnostic Research, 17 (11). DOI: https://doi.org/10.7860/JCDR/2023/65388.18746
Lavretsky, H., Yang, H., Eyre, H., Leaver, A., Narr, K., & Khalsa, D. (2015). M1. Changes in the Functional Brain Connectivity and Verbal Memory Performance Following Yoga or Memory Training in Older Adults with Subjective Memory Complaints. Neuropsychopharmacology, 40, S106-271.
Mishra, S. K., Khosa, S., Singh, S., Moheb, N., & Trikamji, B. (2017). Changes in functional magnetic resonance imaging with Yogic meditation: a pilot study. AYU (An International Quarterly Journal of Research in Ayurveda), 38(3-4), 108-112. DOI: https://doi.org/10.4103/ayu.AYU_34_17
Muralikrishna, D. (2019). Bhagavad Gita” and “Yoga”. International Journal of Yoga and Allied Sciences, 8(2), 148-151.
Najafi, P., & Moghadasi, M. (2017). The effect of yoga training on enhancement of Adrenocorticotropic hormone (ACTH) and cortisol levels in female patients with multiple sclerosis. Complementary therapies in clinical practice, 26, 21-25. DOI: https://doi.org/10.1016/j.ctcp.2016.11.006
Naveen, G. H., Varambally, S., Thirthalli, J., Rao, M., Christopher, R., & Gangadhar, B. N. (2016). Serum cortisol and BDNF in patients with major depression—effect of yoga. International review of psychiatry, 28(3), 273-278. DOI: https://doi.org/10.1080/09540261.2016.1175419
O'Shea, M., Capon, H., Evans, S., Agrawal, J., Melvin, G., O'Brien, J., & McIver, S. (2022). Integration of hatha yoga and evidence‐based psychological treatments for common mental disorders: An evidence map. Journal of Clinical Psychology, 78(9), 1671-1711. DOI: https://doi.org/10.1002/jclp.23338
Padmavathi, R., Kumar, A. P., Dhamodhini, K. S., Venugopal, V., Silambanan, S., Maheshkumar, K., & Shah, P. (2023). Role of yoga in stress management and implications in major depression disorder. Journal of Ayurveda and Integrative Medicine, 14(5), 100767. DOI: https://doi.org/10.1016/j.jaim.2023.100767
Pascoe, M. C., & Bauer, I. E. (2015). A systematic review of randomised control trials on the effects of yoga on stress measures and mood. Journal of psychiatric research, 68, 270-282. DOI: https://doi.org/10.1016/j.jpsychires.2015.07.013
Pascoe, M. C., Thompson, D. R., & Ski, C. F. (2017). Yoga, mindfulness-based stress reduction and stress-related physiological measures: A meta-analysis. Psychoneuroendocrinology, 86, 152-168. DOI: https://doi.org/10.1016/j.psyneuen.2017.08.008
Patil, S. G., Sobitharaj, E. C., Chandrasekaran, A. M., Patil, S. S., Singh, K., Gupta, R., ... & Prabhakaran, D. (2024). Effect of yoga-based cardiac rehabilitation program on endothelial function, oxidative stress, and inflammatory markers in acute myocardial infarction: a randomized controlled trial. International Journal of Yoga, 17(1), 20-28. DOI: https://doi.org/10.4103/ijoy.ijoy_40_24
Pradhan, B. (2015). Yoga: Original concepts and history. Yoga and Mindfulness Based Cognitive Therapy: A Clinical Guide, 3-36. DOI: https://doi.org/10.1007/978-3-319-09105-1_1
Rathore, V. (2023). A scientific exploration of stress management techniques in Patanjali Yog Sutra. Yoga Mimamsa, 55(2), 114-118. DOI: https://doi.org/10.4103/ym.ym_66_23
Santaella, D. F., Balardin, J. B., Afonso, R. F., Giorjiani, G. M., Sato, J. R., Lacerda, S. S., & Kozasa, E. H. (2019). Greater anteroposterior default mode network functional connectivity in long-term elderly yoga practitioners. Frontiers in Aging Neuroscience, 11, 158. DOI: https://doi.org/10.3389/fnagi.2019.00158
Sathyanarayanan, G., Vengadavaradan, A., & Bharadwaj, B. (2019). Role of yoga and mindfulness in severe mental illnesses: A narrative review. International journal of yoga, 12(1), 3-28. DOI: https://doi.org/10.4103/ijoy.IJOY_65_17
Schmalzl, L., Powers, C., & Henje Blom, E. (2015). Neurophysiological and neurocognitive mechanisms underlying the effects of yoga-based practices: towards a comprehensive theoretical framework. Frontiers in human neuroscience, 9, 235. DOI: https://doi.org/10.3389/fnhum.2015.00235
Sciarrino, N. A., DeLucia, C., O'Brien, K., & McAdams, K. (2017). Assessing the effectiveness of yoga as a complementary and alternative treatment for post-traumatic stress disorder: A review and synthesis. The Journal of Alternative and Complementary Medicine, 23(10), 747-755. DOI: https://doi.org/10.1089/acm.2017.0036
Sharma, K., Arya, K., Kumar, S., & Sharma, S. (2024). Neuro-molecular Effects of Yoga and Endurance Exercises: Similarities and Dissimilarities. In Neuroscience of Yoga: Theory and Practice: Part 1, Singapore: Springer Nature Singapore, 139-156. DOI: https://doi.org/10.1007/978-981-97-2851-0_9
Singh, S., Rai, M. S. K., Pandya, B. V., & Kumar, R. (2023). Yoga and meditation. Academic Guru Publishing House.
Smaniotto-Holmes, K. (2024). Learning, Breathing, and Well-Being: Resiliency and Yoga—Contemplations on the Neuroscientific Connection to Curriculum, Teaching, and Learning. Interchange, 55(3), 331-348. DOI: https://doi.org/10.1007/s10780-024-09520-3
Streeter, C. C., Gerbarg, P. L., Saper, R. B., Ciraulo, D. A., & Brown, R. P. (2012). Effects of yoga on the autonomic nervous system, gamma-aminobutyric-acid, and allostasis in epilepsy, depression, and post-traumatic stress disorder. Medical hypotheses, 78(5), 571-579. DOI: https://doi.org/10.1016/j.mehy.2012.01.021
Streeter, C. C., Whitfield, T. H., Owen, L., Rein, T., Karri, S. K., Yakhkind, A., & Jensen, J. E. (2010). Effects of yoga versus walking on mood, anxiety, and brain GABA levels: a randomized controlled MRS study. The journal of alternative and complementary medicine, 16(11), 1145-1152. DOI: https://doi.org/10.1089/acm.2010.0007
Surana, S., Singh, L., Jain, P. K., & Tharwan, A. (2025). The Synergy of Emotional Intelligence, Mental Health, and Physical Fitness: The Impact of Yoga on Daily Life. In Emotional Intelligence in the Digital Era, Auerbach Publications, 311-324. DOI: https://doi.org/10.1201/9781032715377-20
Suri, M., Sharma, R., & Saini, N. (2017). Neuro-physiological correlation between yoga, pain and endorphins. International Journal of Adapted Physical Education and Yoga, 2(9), 18-32.
Tolahunase, M. R., Gautam, S., Sagar, R., Kumar, M., & Dada, R. (2021). Yoga in major depressive disorder: molecular mechanisms and clinical utility. Frontiers in Bioscience-Scholar, 13(1), 56-81. DOI: https://doi.org/10.52586/S553
Tolahunase, M. R., Sagar, R., Faiq, M., & Dada, R. (2018). Yoga-and meditation-based lifestyle intervention increases neuroplasticity and reduces severity of major depressive disorder: A randomized controlled trial. Restorative neurology and neuroscience, 36(3), 423-442. DOI: https://doi.org/10.3233/RNN-170810
Tyagi, A., & Cohen, M. (2016). Yoga and heart rate variability: A comprehensive review of the literature. International journal of yoga, 9(2), 97-113. DOI: https://doi.org/10.4103/0973-6131.183712
Udupa, K., & Sathyaprabha, T. N. (2018). Influence of yoga on the autonomic nervous system. In Research-based perspectives on the psychophysiology of yoga, IGI Global, 67-85. DOI: https://doi.org/10.4018/978-1-5225-2788-6.ch005
Udupa, K., Bhavanani, A. B., & Ramanathan, M. (2022). Stress and the Autonomic Nervous System: Implication of Yoga. In The principles and practice of Yoga in cardiovascular medicine, Springer, 105-115. DOI: https://doi.org/10.1007/978-981-16-6913-2_9
Van Aalst, J., Ceccarini, J., Demyttenaere, K., Sunaert, S., & Van Laere, K. (2020). What has neuroimaging taught us on the neurobiology of yoga? A review. Frontiers in integrative neuroscience, 14, 34. DOI: https://doi.org/10.3389/fnint.2020.00034
Varambally, S., Gangadhar, B. N., Lam, L., & Riba, M. (2016). Yoga-based interventions for the management of psychiatric disorders. Physical Exercise Interventions for Mental Health, 124-146. DOI: https://doi.org/10.1017/CBO9781316157565.010
Veerakannan, S. (2025). Yoga Effects on Brain Health: A Systematic Review of the Current Literature. Aathiyoga Indian Journal of Ancient Medicine and Yoga, 1(05), 171-192.
Virk, H., Seth, S., Rabac, J. K., & Jain, D. (2020). Spirituality, yoga practice & natural dopamine effects. JS International Journal of Multidisciplinary Research, 2(1).
Voss, S., Cerna, J., & Gothe, N. P. (2023). Yoga impacts cognitive health: neurophysiological changes and stress regulation mechanisms. Exercise and sport sciences reviews, 51(2), 73-81. DOI: https://doi.org/10.1249/JES.0000000000000311
Wadden, K. P., Snow, N. J., Sande, P., Slawson, S., Waller, T., & Boyd, L. A. (2018). Yoga practitioners uniquely activate the superior parietal lobule and supramarginal gyrus during emotion regulation. Frontiers in integrative neuroscience, 12, 60. DOI: https://doi.org/10.3389/fnint.2018.00060
Weng, H. Y., Feldman, J. L., Leggio, L., Napadow, V., Park, J., & Price, C. J. (2021). Interventions and manipulations of interoception. Trends in neurosciences, 44(1), 52-62. DOI: https://doi.org/10.1016/j.tins.2020.09.010
Yadav, A., Verma, S., Panwar, M., & Yadav, N. K. (2022). Role of Yoga practices on cognitive functions: A review. International Journal of Health Sciences, (III), 3288-3304. DOI: https://doi.org/10.53730/ijhs.v6nS3.6341
Yashotha, D. (2025). The Power of Yoga and Meditation in Combating Sleep Disorders. Aathiyoga Indian Journal of Ancient Medicine and Yoga, 2(02), 208-214
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