BIOLOGICAL ACTIVITIES OF 1, 3, 4- THIADIAZOLES AND SOME OF THEIR METAL COMPLEXES: A CONCISE REVIEW

Aaliya Rahman; Smriti Singh

doi:10.29121/shodhkosh.v5.i6.2024.4344

Authors

Aaliya Rahman Research Scholar, PG Department of Chemistry, Ranchi University, Ranchi, Jharkhand.
Smriti Singh Assistant Professor, PG Department of Chemistry, Ranchi University, Ranchi, Jharkhand.

DOI:

https://doi.org/10.29121/shodhkosh.v5.i6.2024.4344

Keywords:

1,3, 4-Thiadiazole Derivatives, Metal Complexes, Antimicrobial, Anticancer, Anti-Inflammatory, Anticonvulsant Activity

Abstract [English]

The rise of synthetic drug resistance, the emergence of novel pathogens, and the limitations of existing drugs in treating complex infections necessitate the development of new drug formations with potential effectiveness and new therapies. The nitrogen-containing heterocyclic compounds are crucial across various scientific and industrial fields due to their unique chemical properties and versatility. Thiadiazole is a five-membered heterocyclic compound having two nitrogen and one sulfur atom. Among the four isomers, 1,3,4-thiadiazole showed remarkable biological activity. The 1,3,4-thiadiazole derivatives and their metal complexes have gained attention in medicinal chemistry due to their versatile biological activities as antimicrobial, anticancer, anti-inflammatory, antitubercular, antioxidant, and anticonvulsant activities. The study provides a comprehensive overview of the diverse pharmacological properties exhibited by these compounds and gives an insight into the position of different substituents and their complexation with different metal ions for pharmacological values. Their impact on biological activity, emphasizes the importance of 1,3,4-thiadiazole derivatives in drug development and suggests future research directions to enhance their efficacy and specificity in targeting diseases, combat resistance, and paving the way for the development of novel therapeutic agents.

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