A COMPLETE ANALYSIS OF THE HEALTH BENEFITS, PHYTOCHEMICAL COMPOSITIONS, AND INDUSTRIAL USE OF POLYHYDROXYFLAVAN OLIGOMERS IN GRAPE SEEDS (VITIS VINIFERA)
DOI:
https://doi.org/10.29121/shodhkosh.v5.i5.2024.4251Keywords:
Grape Seeds, Colonic Metabolites, Oligomers, Investigations, Phytochemical ComponentsAbstract [English]
Polyhydroxylflavan oligomers are polymers that can be found in abundance in grape seeds. Due to its conjugated and colonic metabolites, grape seeds have been shown to have significant health benefits. A reciprocal interaction between grape seed polyhydroxyflavan oligomers and the gut flora is possible. Particularly, it has been shown by a number of in vitro and in vivo investigations that grape seed polyhydroxyflavan oligomers seem to have pharmacological effects. They may have anti-oxidative damage defense as well as anti-diabetic, anti-cholesterol, and anti- platelet properties. With an emphasis on investigations of the phytochemical components, pharmacological characteristics, and industrial uses of grape seeds, this review aims to provide an overview of the existing literature on grape seed proanthocyanidins, which are composed of polyhydroxyflavan oligomers.
References
Brannan, R.G. Effect of grape seed extract on descriptive sensory analysis of ground chicken during refrigerated storage. Meat Sci. 2009, 81, 589–595. DOI: https://doi.org/10.1016/j.meatsci.2008.10.014
Brannan, R.G.; Mah, E. Grape seed extract inhibits lipid oxidation in muscle from different species during refrigerated and frozen storage and oxidation catalyzed by peroxynitrite and iron/ascorbate in a pyrogallol red model system. Meat Sci. 2007, 77, 540–546. DOI: https://doi.org/10.1016/j.meatsci.2007.05.001
Roychowdhury, S.; Wolf, G.; Keilhoff, G.; Bagchi, D.; Horn, T. Protection of primary glial cells by grape seed proanthocyanidin extract against nitrosative/oxidative stress. Nitric Oxide 2001, 5, 137–149. DOI: https://doi.org/10.1006/niox.2001.0335
Bagchi, D.; Bagchi, M.; Stohs, S.J.; Das, D.K.; Ray, S.D.; Kuszynski, C.A.; Joshi, S.S.; Pruess, H.G. Free radicals and grape seed proanthocyanidin extract: Importance in human health and disease prevention. Toxicology 2000, 148, 187–197. DOI: https://doi.org/10.1016/S0300-483X(00)00210-9
Fine, A. M. (2000). Oligomeric proanthocyanidin complexes: History, structure, and phytopharmaceutical applications. Alternative Medicine Review, 5(2), 144–151.
Frank, D. N., Amand, A. L. S., Feldman, R. A., Boedeker, E. C., Harpaz, N., & Pace, N. R.
(2007). Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proceedings of the National Academy of Sciences, 104(34), 13780–13785. DOI: https://doi.org/10.1073/pnas.0706625104
Estreicher, S.K. Wine. In The Encyclopedia of Ancient History; Bagnall, R.S., Brodersen, K., Champion, C.B.,Erskine, A., Huebner, S.R., Eds.; JohnWiley & Sons, Inc.: Oxford, UK, 2013; pp. 1–5.ISBN 9781444338386.
Duba, K.S.; Fiori, L. Supercritical CO2 extraction of grape seed oil: Effect of process parameters on the extraction kinetics. J. Supercrit. Fluids 2015, 98, 33–43. DOI: https://doi.org/10.1016/j.supflu.2014.12.021
Cádiz-Gurrea, M.; Borrás-Linares, I.; Lozano-Sánchez, J.; Joven, J.; Fernández-Arroyo, S.; Segura- Carretero, A. Cocoa and grape seed byproducts as a source of antioxidant and anti- inflammatory proanthocyanidins. Int. J. Mol. Sci. 2017, 18, 376. DOI: https://doi.org/10.3390/ijms18020376
Maier, T.; Schieber, A.; Kammerer, D.R.; Carle, R. Residues of grape (Vitis vinifera L.) seed oil production as a valuable source of phenolic antioxidants. Food Chem. 2009, 112, 551–559. DOI: https://doi.org/10.1016/j.foodchem.2008.06.005
Matthäus, B. Virgin grape seed oil: Is it really a nutritional highlight? Eur. J. Lipid Sci. Technol. 2008, 110, 645–650. DOI: https://doi.org/10.1002/ejlt.200700276
Serrano, J., Puupponen-Pimiä, R., Dauer, A., Aura, A. M., & Saura-Calixto, F. (2009). Tannins: Current knowledge of food sources, intake, bioavailability and biological effects. Molecular Nutrition & Food Research, 53(S2), S310–S329. DOI: https://doi.org/10.1002/mnfr.200900039
Sun, B.; Spranger, M.I. Review: Quantitative extraction and analysis of grape and wine proanthocyanidins and stilbenes. Ciência e Técnica Vitivinícola 2005, 20, 59–89.
He, F.; Liang, N.;Mu, L.; Pan, Q.;Wang, J.; Reeves,M.J.; Duan, C. Anthocyanins and their
variation in red wines I. Monomeric anthocyanins and their color expression. Molecules 2012, 17, 1571–1601. DOI: https://doi.org/10.3390/molecules17021571
Yilmaz, Y.; Toledo, R.T. Health aspects of functional grape seed constituents. Trends Food Sci. Technol. 2004, 15, 422–433. DOI: https://doi.org/10.1016/j.tifs.2004.04.006
Szent-Györgyi, A. (1936). Vitamin P: Flavonols as vitamins. Nature, 138(3479), 27. Tan, R.-R., Zhang, S.-J., Li, Y.-F., Tsoi, B., Huang, W.-S., Yao, N., ... Tang, L.-P. (2015). DOI: https://doi.org/10.1038/138027a0
Fine, A. M. (2000). Oligomeric proanthocyanidin complexes: History,structure, and phytopharmaceutical applications. Alternative Medicine Review, 5(2), 144–151.
Masquelier, J. (1991). Historic Note on OPC, Procyanidines de France. In. Martillac,France.
Bate-Smith, E., & Swain, T. (1962). Comparative biochemistry. Eds. Mason, HS, Florkin, M, 3, 764.
Varzakas, T.; Zakynthinos, G.; Verpoort, F. Plant food residues as a source of nutraceuticals and functional foods. Foods 2016, 5, 88. DOI: https://doi.org/10.3390/foods5040088
Quesada, H.; del Bas, J.M.; Pajuelo, D.; Diaz, S.; Fernandez-Larrea, J.; Pinent, M.; Arola, L.; Salvado, M.J.; Blade, C. Grape seed proanthocyanidins correct dyslipidemia associated with a high-fat diet in rats and repress genes controlling lipogenesis and VLDL assembling in liver. Int.journal of Obes. 2009, 33, 1007–1012. DOI: https://doi.org/10.1038/ijo.2009.136
Montagut, G.; Bladé, C.; Blay, M.; Fernández-Larrea, J.; Pujadas, G.; Salvadó, M.J.; Arola, L.; Pinent, M.; Ardévol, A. Effects of a grapeseed procyanidin extract (GSPE) on insulin resistance. J. Nutr. Biochem. 2010, 21, 961–967. DOI: https://doi.org/10.1016/j.jnutbio.2009.08.001
Montagut, G.; Onnockx, S.; Vaqué, M.; Bladé, C.; Blay, M.; Fernández-Larrea, J.; Pujadas, G.;Salvadó, M.J.; Arola, L.; Pirson, I.; et al. Oligomers of grape-seed procyanidin extract activate the insulin receptor and key targets of the insulin signaling pathway differently from insulin. J. Nutr. Biochem. 2010, 21, 476–481. DOI: https://doi.org/10.1016/j.jnutbio.2009.02.003
Olas, B.; Wachowicz, B.; Tomczak, A.; Erler, J.; Stochmal, A.; Oleszek, W. Comparative anti- platelet and antioxidant properties of polyphenol-rich extracts from: Berries of Aronia melanocarpa, seeds of grape and bark of Yucca schidigera in vitro. Platelets 2008, 19, 70–77. DOI: https://doi.org/10.1080/09537100701708506
Natella, F.; Belelli, F.; Gentili, V.; Ursini, F.; Scaccini, C. Grape seed proanthocyanidins prevent plasma postprandial oxidative stress in humans. J. Agric. Food Chem. 2002, 50, 7720–7725. DOI: https://doi.org/10.1021/jf020346o
Aviram, M.; Rosenblat, M.; Bisgaier, C.L.; Newton, R.S.; Primo-Parmo, S.L.; La Du, B.N. Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions. A possible peroxidative role for paraoxonase. J. Clin. Investig. 1998, 101, 1581–1590. DOI: https://doi.org/10.1172/JCI1649
Terra, X.; Pallarés, V.; Ardèvol, A.; Bladé, C.; Fernández-Larrea, J.; Pujadas, G.; Salvadó, J.; Arola, L.; Blay, M. Modulatory effect of grape-seed procyanidins on local and systemic inflammation in diet- induced obesity rats. J. Nutr. Biochem. 2011, 22, 380–387. DOI: https://doi.org/10.1016/j.jnutbio.2010.03.006
Pinent, M.; Blay, M.; Bladé, M.C.; Salvadó, M.J.; Arola, L.; Ardévol, A. Grape seed-derived procyanidins have an antihyperglycemic effect in streptozotocin-induced diabetic rats and insulinomimetic activity in insulin-sensitive cell lines. Endocrinology 2004, 145, 4985–4990. DOI: https://doi.org/10.1210/en.2004-0764
Balu, M.; Sangeetha, P.; Murali, G.; Panneerselvam, C. Modulatory role of grape seed extract on
age-related oxidative DNA damage in central nervous system of rats. Brain Res. Bull. 2006, 68, 469–473. DOI: https://doi.org/10.1016/j.brainresbull.2005.10.007
Balu, M.; Sangeetha, P.; Haripriya, D.; Panneerselvam, C. Rejuvenation of antioxidant system in central nervous system of aged rats by grape seed extract. Neurosci. Lett. 2005, 383, 295–300. DOI: https://doi.org/10.1016/j.neulet.2005.04.042
Park, S.Y.; Lee, Y.H.; Choi, K.C.; Seong, A.R.; Choi, H.K.; Lee, O.H.; Hwang, H.J.; Yoon, H.G.
Grape seed extract regulates androgen receptor-mediated transcription in prostate cancer cells through potent anti-histone acetyltransferase activity. J. Med. Food 2011, 14, 9–16. DOI: https://doi.org/10.1089/jmf.2010.1264
Feng, Y.; Liu, Y.M.; Fratkins, J.D.; LeBlanc, M.H. Grape seed extract suppresses lipid peroxidation and reduces hypoxic ischemic brain injury in neonatal rats. Brain Res. Bull. 2005,66,120–127. DOI: https://doi.org/10.1016/j.brainresbull.2005.04.006
Sano, A.; Uchida, R.; Saito, M.; Shioya, N.; Komori, Y.; Tho, Y.; Hashizume, N. Beneficial effects of grape seed extract on malondialdehyde-modified LDL. J. Nutr. Sci. Vitaminol. 2007, 53, 174–182. DOI: https://doi.org/10.3177/jnsv.53.174
Mielnik, M.B.; Olsen, E.; Vogt, G.; Adeline, D.; Skrede, G. Grape seed extract as antioxidant in cooked, cold stored turkey meat. Food Sci. Technol. 2006, 39, 191–198. DOI: https://doi.org/10.1016/j.lwt.2005.02.003
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 A. Renuka Devi, Dr. M. Velvizhi

This work is licensed under a Creative Commons Attribution 4.0 International License.
With the licence CC-BY, authors retain the copyright, allowing anyone to download, reuse, re-print, modify, distribute, and/or copy their contribution. The work must be properly attributed to its author.
It is not necessary to ask for further permission from the author or journal board.
This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge.