MAGNETIC DRUG TARGETING USING MAGNETIC NANOPARTICLES FOR CANCER THERAPY

Hatice Bilgili

doi:10.29121/ijoest.v10.i2.2026.746

Authors

Hatice Bilgili Department of Biomedical Engineering, Engineering Faculty, Inonu University, Malatya, Turkey https://orcid.org/0000-0002-3897-8835

DOI:

https://doi.org/10.29121/ijoest.v10.i2.2026.746

Keywords:

Magnetic Drug Targeting, MDT, Cancer Therapy, Magnetic Nanoparticles, MNPs, Targeted Drug Delivery

Abstract

Globally, cancer is still among the most frequent causes of mortality.Traditional cancer treatment modalities, including surgery, radiotherapy, and chemotherapy, present limited selectivity and severe side effects. Chemotherapeutic agents target the growth and survival of rapidly dividing cancer cells, but they can also kill healthy cells through systemic circulation. Hence, the quest for specific drug-targeting systems for tumor-targeting agents in the therapeutic arm has attracted considerable attention in cancer therapy. Magnetic nanoparticles (MNPs) have attracted significant attention in biomedical research owing to their specific physical and features such as their small particle size and high surface-to-volume, and superparamagnetic behavior. Magnetite (Fe₃O₄) and maghemite (γ-Fe₂O₃), which belong to the iron oxide nanoparticle family, are extensively investigated for biomedical because they are biocompatible and exhibit controllable magnetic properties. These nanoparticles can be functionalized with biocompatible coatings and anticancer agents to develop magnetic drug delivery systems. Magnetic Drug Targeting (MDT) is reliesed on the principle of magnetic nanoparticles conjugated with therapeutic agents directed to the cancerous tissue region by a magnetic field applied externall Such an approach makes increased drug accumulation within the targeted tissue possible, and a substantial impact has been achieved with systemic toxicity and side effects minimized. Furthermore, magnetic nanoparticles have been applied widely across biomedical fields, including magnetic resonance imaging (MRI), hyperthermia therapy, biosensors, and tissue engineering. The basic properties of magnetic nanoparticles, their biocompatibility, their application in cancer anticancer drug targeting using magnetic drug, and their properties in the context of the basic characteristics are investigated in this review as well. In addition, discussion has been provided on magnetic targeting dynamics, drug applications, and anti-cancer drugs with magnetic nanoparticles, as well as targeted drug system issues, based on the available literature. Drug delivery using magnetic nanoparticle systems is a promising strategy for optimizing cancer treatment while minimizing side effects.

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