THE POSSIBLE EFFECTS OF POLYAMINES IN MULTIPLE SCLEROSIS PATIENTS ON NEW LESION DEVELOPMENT AND DISABILITY

Asli Bolayir; Veysel Kenan Celik; Hasan Ata Bolayir; Serkan Kapancik; Hasan Kilicgun; Seyda Figul Gokce

doi:10.29121/granthaalayah.v6.i6.2018.1401

Authors

Asli Bolayir Cumhuriyet University, Medicine Faculty, Neurology Department, Sivas, Turkey
Veysel Kenan Celik Cumhuriyet University Medicine Faculty Biochemistry Department, Sivas, Turkey
Hasan Ata Bolayir Sivas Numune State Hospital, Cardiology Department, Sivas, Turkey
Serkan Kapancik Cumhuriyet University Medicine Faculty Biochemistry Department, Sivas, Turkey
Hasan Kilicgun Erzincan University, Health Science Faculty, Nutrition and Dietetics Department, Erzincan, Turkey
Seyda Figul Gokce Cumhuriyet University, Medicine Faculty, Neurology Department, Sivas, Turkey

DOI:

https://doi.org/10.29121/granthaalayah.v6.i6.2018.1401

Keywords:

Multiple Sclerosis, Polyamine Synthesis Pathway, Ornithine Decarboxylase, Arginine Decarboxylase, Agmatinase

Abstract [English]

Background: Multiple sclerosis (MS) is a demyelinating autoimmune disease characterized by the infiltration of T cells into the central nervous system. Polyamines, which contribute to cell proliferation, hypertrophy and tissue development, have some tissue-specific roles in brain tissue. So, we aimed in this study to present the possible effects of polyamines on MS.

Method: Thirty- five patients with MS and 35 sex and age-matched control were included in this study. Arginine decarboxylase (ADC), ornithine decarboxylase (ODC) and agmatinase levels were measured by ELISA kits.

Results: The patient group had higher ODC and agmatinase levels than controls. The correlation analyses between ODC, ADC, and agmatinase levels and disease duration were revealed that there was a negligible positive relationship between disease duration and agmatinase, with negligible negative relationship between disease duration and ODC and ADC. Additionally, there were showed respectively moderate and weak positive correlations between EDSS (Expanded Disability Status Scale) scores and newly developed lesions and ODC and agmatinase levels.

Conclusions: Elevated polyamine synthesis in MS patients was presented by detecting increased ODC, ADC and agmatinase levels compared to controls. Besides this increased polyamine synthesis in MS patients was also related with disease duration, number of newly developed lesions and disability.

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