CAN INCREASED MONOCYTE / LYMPHOCYTE RATIO BE USED AS AN INDICATOR FOR ALZHEIMER'S DISEASE?
DOI:
https://doi.org/10.29121/granthaalayah.v6.i4.2018.1644Keywords:
Dementia, Monocyte, Lymphocyte, Monocyte/Lymphocyte Ratio, Alzheimer's DiseaseAbstract [English]
Background: The monocyte to lymphocyte ratio (MLR) obtained by dividing the number of monocytes by lymphocyte number is considered as a new marker of inflammation. The role of MLR in Alzheimer's disease (AD) has not been clearly understood yet. So, the aim of this study is to determine the role of MLR in the pathogenesis of AD.
Method: Our study is a single centered retrospective study. 254 patients with AD, who applied to our clinic between January 2013 and December 2017 and 256 healthy control with similar age and sex were included to this study.
Results: While lymphocyte count was lower in the control group; MLR values were higher in the patient group. The patient group was then divided into three subgroups according to the results of standardized mini mental test (SMMT). MLR values increased in parallel with the severity of AD. In addition, ROC analysis revealed that MLR values above 0.28 can be used as a marker of the development of AD (AUC: 0.76, 95% CI: 0.66–0.87, sensitivity: 73.1%, specificity of 81.1%).
Conclusions: This study demonstrated the role of MLR in the inflammatory process, thought to be responsible for the development of AD.
Downloads
References
Prince, M. J. (2015). World Alzheimer Report 2015: the global impact of dementia: an analysis of prevalence, incidence, cost and trends. Alzheimer's Disease International.
Gürvit, H.(2014). Sinir Sisteminin Dejeneratif Hastalıkları. Demans Sendromu, Alzheimer Hastalığı ve Alzheimer dışı demanslar. In: Öge AE; eds. Nöroloji. İstanbul: Nobel Matbaacılık: 367- 415.
Glenner, G. G., & Wong, C. W. (1984). Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochemical and biophysical research communications, 120(3), 885-890. DOI: https://doi.org/10.1016/S0006-291X(84)80190-4
Bird, T. D. (2001). Alzheimer's disease and other primary dementias. Harrisons principles of internal medicine, 2, 2391-2398.
Lee, K. S., Chung, J. H., Choi, T. K.,et al. (2009). Peripheral cytokines and chemokines in Alzheimer’s disease. Dementia and geriatric cognitive disorders, 28(4), 281-287. DOI: https://doi.org/10.1159/000245156
Wilson, E. H., Weninger, W., & Hunter, C. A. (2010). Trafficking of immune cells in the central nervous system. The Journal of clinical investigation, 120(5), 1368-1379. DOI: https://doi.org/10.1172/JCI41911
Imtiaz, F., Shafique, K., Mirza, S. S., et al (2012). Neutrophil lymphocyte ratio as a measure of systemic inflammation in prevalent chronic diseases in Asian population. International archives of medicine, 5(1), 2.. DOI: https://doi.org/10.1186/1755-7682-5-2
Kuyumcu, M. E., Yesil, Y., Oztürk, Z. A., et al. (2012). The evaluation of neutrophil-lymphocyte ratio in Alzheimer’s disease. Dementia and geriatric cognitive disorders, 34(2), 69-74. DOI: https://doi.org/10.1159/000341583
Song, W., Tian, C., Wang, K., et al. (2017). The pretreatment lymphocyte to monocyte ratio predicts clinical outcome for patients with hepatocellular carcinoma: A meta-analysis. Scientific Reports, 7, 46601. DOI: https://doi.org/10.1038/srep46601
Ren, H., Liu, X., Wang, L., & Gao, Y. (2017). Lymphocyte-to-monocyte ratio: A novel predictor of the prognosis of acute ischemic stroke. Journal of Stroke and Cerebrovascular Diseases, 26(11), 2595-2602. DOI: https://doi.org/10.1016/j.jstrokecerebrovasdis.2017.06.019
Ren, H., Han, L., Liu, H., et al. (2017). Decreased Lymphocyte-to-Monocyte Ratio Predicts Poor Prognosis of Acute Ischemic Stroke Treated with Thrombolysis. Medical science monitor: international medical journal of experimental and clinical research, 23, 5826.
Fiala, M., Liu, Q. N., Sayre, J., et al. (2002). Cyclooxygenase‐2‐positive macrophages infiltrate the Alzheimer’s disease brain and damage the blood–brain barrier. European journal of clinical investigation, 32(5), 360-371. DOI: https://doi.org/10.1046/j.1365-2362.2002.00994.x
Simard, A. R., Soulet, D., Gowing, G., et al. (2006). Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease. Neuron, 49(4), 489-502. DOI: https://doi.org/10.1016/j.neuron.2006.01.022
Malavolta, M., Basso, A., Piacenza, F., et al. (2013). Peripheral mononuclear cell rejuvenation for senescence surveillance in Alzheimer disease. Current pharmaceutical design, 19(9), 1720-1726.
Bolayır, A., & Gökçe, Ş. F. (2017). The role of mean platelet volume, platelet distribution width and platelet/lymphocyte ratio in development of cerebral venous thrombosis. Cumhuriyet Medical Journal, 39(4), 683-691. DOI: https://doi.org/10.7197/223.v39i32356.369336
Enciu, A. M., & Popescu, B. O. (2013). Is there a causal link between inflammation and dementia?. BioMed research international, 2013. DOI: https://doi.org/10.1155/2013/316495
Downloads
Published
How to Cite
Issue
Section
License
With the licence CC-BY, authors retain the copyright, allowing anyone to download, reuse, re-print, modify, distribute, and/or copy their contribution. The work must be properly attributed to its author.
It is not necessary to ask for further permission from the author or journal board.
This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge.