• Abd Elwahab Abdien Department of Clinical Chemistry- Faculty of Laboratory Sciences- Shendi University-Sudan
  • Haghamad Allzain Mohamed Bulla Assistant Professor In The Department Of Biochemistry- Faculty Of Medicine- Shendi University –Sudan
  • Motwakil lmam Awadelkareim lmam Department of Medicine- Faculty of Medicine- Shendi University-Sudan
  • Azahir Yousif Department of Medicine, Faculty of Medicine, Shendi University, Sudan
  • Tarig . A.H. Karar Department of Clinical Chemistry- Faculty of Applied Medical Sciences- King Saud University- KSA.
  • M. H. Eltayeb Faculty of Developmental studies- Shendi University-Sudan
  • Rashid Eltayeb Department of Biochemistry, Faculty of Medicine, Shendi University, Department of Biochemistry, Faculty of Medicine, Elsheikh Abdallah Elbadri University (EAEU), Sudan



Thyroid Gland, Thyroid Hormones, Thyroid Dysfunction, Hypothyroidism, Hyperthyroidism, Thyroid Auto-Antibodies, TSH, TT4, fT4, TT3, fT3, TPO Ab, Tg Ab

Abstract [English]

Background:  Thyroid disorders are the most second endocrine problem after diabetes mellitus in society. Environmental, immunological, and genetic factors   lead to the development of thyroid disorders.

 Objectives: The study intended to evaluate the role of thyroid antibodies and hormones in the diagnosis of thyroid diseases, as well as the prevalence of thyroid antibodies in patients having thyroid disorders living   in Shendi locality.

Study design: The current research was prospective, case - control, hospital-based study carried out from 2013-2017, in El-Mek Nimir Uiversity Hospital in Shendi town- Northern Sudan.-. River Nile State. Two hundred and eighty-three (283) participants selected randomly as study population, of whom Hundred and eleven (111) patients with hypothyroidism; Seventy-two (72) patients with hyperthyroidism; Hundred (100) healthy normal subjects as control group.  Participants were recruited from outpatient clinics in El-Mek Nimir Uiversity Hospital in Shendi Thyroid hormones profile (TSH, T4, T3, fT3, and fT4) and Thyroid antibodies (Anti-thyroid peroxidase and antithyroglobulin) were measured.

Results: The study revealed that (60.7%) had hypothyroidism, (39.3%) had

hyperthyroidism, (91.9%) of hypothyroidism were female, and only (8.1%) were male, while (84.7%) of hyperthyroidism were female while male represented only (15.3%) of them.

The current study revealed that 107 of the case group (58.5%) were positive when evaluated for thyroid peroxidase antibodies (TPO Ab), with level more than (40.0 IU/ml).  72 (64.9%) of them were hypothyroidism, whereas a 35 (48.6%) of them were hyperthyroidism. As regard Thyroglobulin antibodies (Tg Ab), 73 (39.9%) of the case studied were positive, 51 (69.9%) of them were hypothyroidism, and 22 (30.1%) of them were hyperthyroidism.

The study also revealed statistically significant positive correlation between the presence of TPO Ab and the values of fT3


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How to Cite

Abdien, A. E., Mohamed Bulla, H. A., Awadelkareim lmam, M. lmam, Yousif, A., Karar, T. . A., Eltayeb, M. H., & Eltayeb, R. (2022). ASSOCIATION OF SERUM AUTO-ANTIBODIES AND THYROID FUNCTION TEST IN PATIENTS WITH NON-NEOPLASTIC THYROID DISEASES IN SHENDI LOCALITY, SUDAN. International Journal of Research -GRANTHAALAYAH, 10(2), 179–187.