EVALUATION OF RENAL FUNCTION IN SUDANESE DIABETIC AND HYPERTENSIVE PATIENTS IN SHENDI LOCALITY AT RIVER NILE STATE
Keywords:Diabetes mellitus, Hypertension, Microalbuminuria, Albumin/Creatinine Ratio (ACR), Creatinine
Microalbuminuria in urine is a known indicator of renal dysfunction. It has been extensively studied in the diabetes mellitus and hypertensive patients. This study was cross-sectional, descriptive case-control, hospital based, conducted, in Shendi locality at River Nile State in Northern Sudan, from March to July 2018. It intended to examine the effect of diabetes mellitus and hypertension on renal function. Urine and venous blood samples were collected sixty (60) volunteer subjects, thirty-five (35) of them known as diabetic and hypertensive patients as case group, twenty-five (25) healthy subjects as control group. Samples were examined for urine microalbuminuria and plasma creatinine levels. Case and control groups were compared by age, gender and exercise. Albumin/Creatinine Ratio (ACR). was also assessed. The mean microalbuminuria and mean ACR were significantly higher in case group (38.304mg/dl, (6.8226) mg/mmol) compared to control group (13.020mg/dl, 2.4512) mg/mmol.), with statistically significant P. value (0.007) and (0.000) respectively. There was statistically insignificant variation of the means of plasma creatinine between case and control groups (0.88, 0.948) mg/dl with P. value of (0.285). The present study concluded that diabetes and hypertension were associated with microalbuminuria and renal dysfunction.
American Diabetes Association. Diagnosis and Classification of Diabetes Mellitus. Diabetes Care. 2010;33(Suppl 1): S62-S69. DOI: https://doi.org/10.2337/dc10-S062
Bramlage P, Wittchen H, Pittrow D, Dikow R, Kirch W, Lehnert H, et al. Diabetes, hypertension and microalbuminuria in primary care. Fortschritte der MedizinOriginalien. 2003; 121:33-8.
Camille A. Jones, Mildred E. Francis, Mark S. et al. Eberhardt, Microalbuminuria in the US population: Third National Health and Nutrition Examination Survey. American Journal of Kidney diseases (AJKD). March 2002; Volume 39, Issue 3, Pages 445–45 DOI: https://doi.org/10.1053/ajkd.2002.31388
Chugh A, Bakris GL. Microalbuminuria: what is it? Why is it important? What should be done about it? An update. The Journal of Clinical Hypertension. 2007;9(3):196-200. DOI: https://doi.org/10.1111/j.1524-6175.2007.06445.x
Da Silva Marques P, Carvalho D, Nazaré J, Martins L, Aguiar C, Manso M, et al. Prevalence of microalbuminuria in hypertensive patients with or without type 2 diabetes in a Portuguese primary care setting: The RACE (micRoAlbuminsCreeningsurvEy) study. Revistaportuguesa de cardiologia: orgaooficial da Sociedade Portuguesa de Cardiologia= Portuguese journal of cardiology: an official journal of the Portuguese Society of Cardiology. 2015;34(4):237-46. DOI: https://doi.org/10.1016/j.repce.2014.08.027
Fowler MJ. Microvascular and macrovascular complications of diabetes. Clinical diabetes. 2008;26(2):77-82. DOI: https://doi.org/10.2337/diaclin.26.2.77
George L. Bakris and Mark Molitch. Microalbuminuria as a Risk Predictor in Diabetes: The Continuing Saga. Diabetes Care 2014; 37:867–875 DOI: https://doi.org/10.2337/dc13-1870
Global health estimates 2014- WHO. summary tables: Estimated deaths by cause, sex and WHO Member State 2012. Geneva: World Health Organization;2014.
(http://www.who.int/healthinfo/global_burden_disease/estimates/en/index.html, accessed 12 October 2014)
Global status report on non-communicable diseases 2014. Geneva: WHO; 2014 (http://apps.who.int/iris/bitstream/10665/148114/1/9789241564854_eng.pdf.).
Grendelmeier I. Renal hypertension--the role of the kidneys in blood pressure regulation and the kidneys as end organ. TherapeutischeUmschau Revue therapeutique. 2015;72(6):369-74. DOI: https://doi.org/10.1024/0040-5930/a000688
Hind Eliadarous .2017. Exploring the impact of diabetes in Sudan: Out-of-pocket expenditure and social consequences of diabetes on patients and their families. PhD thesis Karolinska Institutet. Department of Public Health Sciences. Division of Global Health-Health System and Policy, p 3. (ISBN 978-91-7676-753-5)
IDF Diabetes Atlas:2011. P;23
K.T. Mills, J.D. Bundy, T.N. Kelly, et al. Global disparities of hypertension prevalence and control: a systematic analysis of population-based studies from 90 countries. Circulation, 134 (2016), pp. 441-450
Mogensen C. Microalbuminuria and hypertension with focus on type 1 and type 2 diabetes. Journal of internal medicine. 2003;254(1):45-66. DOI: https://doi.org/10.1046/j.1365-2796.2003.01157.x
N. K. Chowta, P. Pant, and M. N. Chowta. Microalbuminuria in diabetes mellitus: Association with age, sex, weight, and creatinine clearance. Indian J Nephrol. 2009 Apr; 19(2): 53–56. DOI: https://doi.org/10.4103/0971-4065.53322
Non-communicable diseases country profiles. Geneva: World Health Organization;2014 (http://www.who.int/nmh/countries/en/, accessed 12 October 2014).
Olokoba AB, Obateru OA, Olokoba LB. Diabetes Mellitus: A Review of Current Trends. Oman Medical Journal. 2012;27(4):269-273. DOI: https://doi.org/10.5001/omj.2012.68
Palatini P. Microalbuminuria in hypertension. Curr Hypertens Rep. 2003 Jun;5(3):208-14. DOI: https://doi.org/10.1007/s11906-003-0022-0
Petrie JR, Guzik TJ, Touyz RM. Diabetes, hypertension and cardiovascular disease: Clinical insights and vascular mechanisms. Canadian Journal of Cardiology. 2017. DOI: https://doi.org/10.1016/j.cjca.2017.12.005
Saeed M. Omar, Imad R. Musa, Amir El Souli, and Ishag Adam. Prevalence, risk factors, and glycaemic control of type 2 diabetes mellitus in eastern Sudan: a community-based study. Ther Adv Endocrinol Metab. 2019; 10 DOI: https://doi.org/10.1177/2042018819860071
Sudan Health Profile 2015 / World Health Organization. Regional Office for the Eastern Mediterranean
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