• Ghufran T. Sadeek Chemistry Dept.College Of Education Of Pure Science,Mosul University-Iraq
  • Mohammad S.Al-jely Chemistry Dept.College Of Education For Girls, Mosul University-Iraq
  • Neim H. Saleem Chemistry Dept.College Of Education Of Pure Science,Mosul University-Iraq
Keywords: New, Approach, Aroyloxy, Oxazines


Oxazine compounds have drew the attention  of many researchers to find different approaches to the synthesis of this type of compounds  according to the success of their use in a wide range of pharmaceutical application during the last decades  .It is  also for the difference    reactivity of these analogues is exhaustively depicted and illustrates the rich versatility of this class of starting material. They proved to have  most of actions of a combination of other drugs. We are herein investigate the synthesis of ethyl aryloxy acetate(S1-6)  from the reaction of the corresponding ethyl bromo acetate with aryl phenols .These intermediates were cyclized with antharanilic acid affording the titled compounds


M.SAl-Ajely, J.M.Ali Al-Rawi, J.A. Elvidge(1982)Heterocyclic syntheses with malonyl dichloride. Part 13. 6-Chloro-4-hydroxy-2-oxopyran-3-carboxanilides from N-sulphinylanilines and further reactions of malonyl dichloride with thiocyanates Journal of the Chemical Society Perkin Transact, vol.1,1575.

M.S. Al-Ajelyand H.A. Basher (2007) Synthesis of Some Substituted Pyrano 1, 3-oxazin, Iraqi National Journal of Chemistry, vol. 28,695-703.

M.S.Al-jelly(2013)Synthesis and Antiplatelet of 2-(ethyl amino acid esters), Amino pyridyl 1,3-oxzine8) ,J.of advance in Chemistry,vol.2,No.2 ,91.

M.R. Taati, M. Mamaghani, N.O. Mahmoodi and A. oghmanifar(2009) A Simple Access to the Synthesis of 5,6-Dihydro-4H-1,3-Oxazines Under Solvent-Free Conditions and Microwave Irradiation, Transactions C. Chemistry and Chemical Engineering, vol.16, No. 1, 17-21

Nadeem Siddiquia, Ruhi Alia, M. Shamsher Alama, Waquar Ahsana(2010) Pharmacological Profile of Benzoxazines, J. Chem. Pharm. Res.,vol. 2,No4,309-316.

A.El-Mekabaty (2013) Chemistry of 4H-3,1-Benzoxazin-4-ones, International Journal of Modern Organic Chemistry, vol.2No.2,81-121.

S. Sayaji. Didwagh, B. Pravina. Piste(2013) Novel one - pot Synthesis and Antimicrobial Activity of 6-chloro-2,4- diphenyl 3,4-dihydro-2H-1,3-benzoxazine derivatives, International Journal of ChemTech. Research, Vol.5, No.5, 2199-2203,

G. Thirunarayanan, R. Sundararajan and R. Arulkumaran (2013) Aryl Chalcones as Efficient Precursors for DerivingOxazine: Solvent-free Synthesis and Antimicrobial Activities of some Oxazine-2-amines, International Letters of Chemistry, Physics and Astronomy. 23, 82-97.

S. Sayaji. Didwagh and B. Pravina. Piste(2013) green synthesis of thiazine and oxazine derivatives - a short review, International Journal of Pharmaceutical Sciences and Research Vol. 4, Issue 6,2045-61.

Chaitra G and Rohini RM (2018) Synthesis of 1,3-Oxazine derivative from Chalcone and Screening for their Anti-Oxidant and Anti-Inflammatory activity, International Research Journal of Pharmaceutical and Biosciences, 4 No.19-27.

V. Sharma, K. Pradeep. Jaiswal , Mukesh saran, Dharmendra Kumar Yadav , Saloni , Manas Mathur , Ajit K. Swami , Sanjeev (2018) Discovery of C-3 Tethered 2-oxo-benzo[1,4]oxazines as Potent Antioxidants ;Bio inspired Based Design, Synthesis , Biological evaluation,Cytoxic and in Silico molecular docking studies, Frontires in chemistry,vol.6,56. DOI:

J.C. Wouter. de Bruijna, Jos A. Hagemanb, Carla Araya-Cloutiera, Harry Gruppena,Jean-Paul Vinckena(2018) QSAR of 1,4-benzoxazin-3-one antimicrobials and their drug design perspectives, Bioorganic & Medicinal Chemistry,vol.26,6105-6114.

Dadmohammad Balouchzehi and & Alireza Hassanabadi (2019) Synthesis of 2-Aryl-4-Thioxo-4H-Naphtho[2,3-e] [1,3]Oxazine-5,10-Dione under Solvent-Free Conditions at Ambient Temperature, The Journal of the International Society for Polycyclic Aromatic Compounds,

Egemen Foto, Çigdem Özen, Fatma Zilifd,Betül, Tekiner-Gülbaşİlkay Yıldı, Esin Akı-Yalçın, Nuran Diril İsmail Yalçın(2020) Benzoxazines as new human topoisomerase I inhibitors and potential poisons, DARU Journal of Pharmaceutical Sciences,2865-73.

Seyed Gholamhossein Mansouri, Hassan Zali-Boeini, Kamiar Zomorodian وBahman Khalvati, Razie Helali Pargali, Ali ehshahri, Hadi Amiri Rudbari,Mehdi Sahihi, Zahra Chavoshpour(2020) Arabian Journal of Chemistry, vol. 13, 1271–1282.

IM Shaban1 and Mohammad S Al-Jelly (2019) Synthesis of Some Heterocyclic Compounds Derivedfrom Furfural Using Ultrasonic Waves, Bio medical J. of scientific and Technical research, vol. 22, No.1,16300-5.

G.T. Sadeek, M.S. AlAjely , N. H. Saleem(2020) Synthesis of some oxazine compounds derived from phenols & 8-hydroxy quinolone, Solid State Technology, Vol. 63 Issue: 5,3179-3192.

M. S .Al-Ajely and A. M .Noori(2020) An Efficient and Solvent Free Synthesis of N-Aryl2,3-Dihydro-4H naphtho-[2,1-e] 1,3-oxazines,Bio medical J. of scientific and Technical research, vol.29,No.3,22510-16.

P. Panneerselvam and G.G. Ganesh, (2011), Synthesis and Antimicrobial Screening of Some Novel 2, 5-Disubstituted 1, 3, 4-oxadiazole Derivatives,E- Journal of Chemistry, (8)S1:S149-S154. DOI:

S.F. Mohamed , M. Youssef , Abd El-Galil E. Amr , E.R. Kotb , (2008) , Antimicrobial Activities of Some Synthesized Pyridines, Oxazines and Thiazoles from 3-Aryl-1-(2-naphthylprop-2-en-1-one), Scientia Pharmaceutica, vol.76,279-303

How to Cite
Sadeek, G. T., S.Al-jely, M., & Saleem, N. H. (2020). NEW APPROACH FOR THE SYNTHESIS OF ARYLOXY 1,3-OXAZINES. International Journal of Research -GRANTHAALAYAH, 8(11), 137-144.