GLYCOGEN AND ATRIAL FIBRILLATION ATRIAL MYOCYTES CONTRACTILITY AS MECHANICAL FACTOR SHIFTING INTRACELLULAR GLYCOGEN AGAINST INTERCALATED DISCS

Authors

DOI:

https://doi.org/10.29121/granthaalayah.v8.i11.2020.2075

Keywords:

Atrial Fibrillation, Glycogen, Gap Junctions, Atrial Contractility, Gap Junction Blockage, Genesis Atrial Fibrillation

Abstract [English]

The purpose of this communication is to introduce in the medical literature an additional factor until now hypothesized action of atrial cells depolarization as factor in intracellular flow of glycogen molecules coalescing against the gap junctions. The demonstrated effect of gap junction blockers on paired cells contractility combined with gap junction’s selectivity towards glycogen molecules; and the visualization of contrasting intracellular glycogen images during atrial fibrillation are shown. Published data supporting atrial myocytes contraction as a mechanism in intracellular glycogen molecules migration and its deleterious effects leading into atrial fibrillation (AF) is proposed.

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References

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Zhang, L., Huang, B., Scherlag, B. J., Ritchey, J. W., Embi, A. A., Hu, J., Hou, Y., & Po, S. S. (2015). Structural changes in the progression of atrial fibrillation: potential role of glycogen and fibrosis as perpetuating factors. International journal of clinical and experimental pathology, 8(2), 1712–1718.

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Published

2020-12-02

How to Cite

Embi, A. A. (2020). GLYCOGEN AND ATRIAL FIBRILLATION ATRIAL MYOCYTES CONTRACTILITY AS MECHANICAL FACTOR SHIFTING INTRACELLULAR GLYCOGEN AGAINST INTERCALATED DISCS. International Journal of Research -GRANTHAALAYAH, 8(11), 106–111. https://doi.org/10.29121/granthaalayah.v8.i11.2020.2075

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