POLOXAMER 407 GEL FOR TOPICAL ADMINISTRATION: INFLUENCE OF ACETIC ACID AND DEMINERALIZED WATER ON THE BEHAVIOR OF THE GEL OBTAINED

Dally Li; Lia Gja; N'guessan  A; Aka Any-Grah; Tuo A; N'guessan C; Koffi Aa

doi:10.29121/granthaalayah.v7.i6.2019.803

Authors

Dally Li Department of Pharmacy Galenic, School of Pharmacy, University of Félix Houphouët Boigny, Côte d’Ivoire.01 BP V 34 Abidjan
Lia Gja Department of Pharmacy Galenic, School of Pharmacy, University of Félix Houphouët Boigny, Côte d’Ivoire.01 BP V 34 Abidjan
N'guessan A Department of Pharmacy Galenic, School of Pharmacy, University of Félix Houphouët Boigny, Côte d’Ivoire.01 BP V 34 Abidjan
Aka Any-Grah Department of Pharmacy Galenic, School of Pharmacy, University of Félix Houphouët Boigny, Côte d’Ivoire.01 BP V 34 Abidjan
Tuo A Department of Pharmacy Galenic, School of Pharmacy, University of Félix Houphouët Boigny, Côte d’Ivoire.01 BP V 34 Abidjan
N'guessan C Department of Pharmacy Galenic, School of Pharmacy, University of Félix Houphouët Boigny, Côte d’Ivoire.01 BP V 34 Abidjan
Koffi Aa Department of Pharmacy Galenic, School of Pharmacy, University of Félix Houphouët Boigny, Côte d’Ivoire.01 BP V 34 Abidjan

DOI:

https://doi.org/10.29121/granthaalayah.v7.i6.2019.803

Keywords:

Thermosensitive, Poloxamer, Gel, Topical Administration

Abstract [English]

Background: Poloxamers are low-toxicity copolymers whose aqueous solutions can pass reversibly from the ground state to the gel state at temperatures approaching body temperature, which is of interest for their use as a reservoir system of active principle. Understand the effect of the type of solvent on the rheological characteristics of the gel obtained.

Methods: Various formulations of Poloxamer 407 gel at 16% and 17,5% were prepared and evaluated successively in acetic acid and demineralised water. The main evaluation parameters were the gelling temperature (T _gel) and the concentration of these different solvents.

Results: The T (gel) at 16% F127 in demineralised water and 0.1M acetic acid was 27º ± 0.3 and 17.5% at 25º to 29ºC ± 0.1. in 0.1M and 16 % acetic acid, there is no marked gelation. At 17.5% F127 in acetic acid, gelationwas observed and the T_gel was higher than with F127 in deionized water.

Conclusion: The gelation process is favored by increasing the concentration of F127 and is substantially disadvantaged by 0.1M acetic acid.

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