EFFECT OF GLYCAEMIC CONTROL ON PITUITARY GONADOTROPHINS OF TYPE 2 DIABETIC SUBJECTS IN ENUGU, NIGERIA
DOI:
https://doi.org/10.29121/granthaalayah.v6.i8.2018.1257Keywords:
Glycaemic Control, Pituitary Gonadotrophins;, Diabetes MellitusAbstract [English]
Glycation is considered to be the main molecular basis of several diabetic complications. Association between chronic hyperglycaemia and the development of long-term diabetic-specific complications have been reported but are yet to be completely understood. In this study, the effect of glycaemic control on pituitary gonadotrophins (FSH and LH) was evaluated in male and female diabetics in Enugu, Nigeria. Two hundred and twenty four (240) diabetic patients (92 males and 148 females) within the age range of 31 – 73 years, who were receiving treatment, were randomly recruited for the study. One hundred and thirty four (134) age- and sex-matched apparently healthy volunteers (44 males and 90 females) were recruited as the control subjects. The study subjects were grouped into three categories: Male population (40-72 years), Group A Female population (<50 years) and Group B Female population (≥50 years). The impact of glycaemic control on various parameters was evaluated by classifying the diabetic patients into 3 subgroups on the basis of their HbA1c levels: Good (HbA1c < 7%), Fair (HbA1c 7 to 8%) and (Poor HbA1c > 8 %) glycaemic status. Fasting blood sugar, HbA1c, FSH and LH were determined for all the subjects. The results obtained revealed that the male diabetics had significantly lower (p<0.05) FSH levels when compared with the control subjects. In the two groups of female diabetic subjects, the FSH levels were significantly lower (p<0.05) when compared with their respective control subjects. The glycaemic control evaluation and correlation of HbA1c with the gonadotrophins in the male diabetic population show no statistically significant results. However, in the female diabetic population, subjects with poor glycaemic status show significantly increased (p<0.001) LH levels compared to those with good glycaemic control. In addition, in group B female diabetic population, HbA1c gave significant positive correlation with both FSH (r=0.261, p=0.014) and LH (r = 0.338, p<0.001). This suggests that there is a direct relationship between HbA1c and the gonadotrophic hormones. As glycaemic control is compromised, these hormones tend to increase. This study generally reveals increasing trend in the levels of the gonadotrophins across the different glycaemic status. It can be concluded that good glycaemic control of diabetes can exert better influences on pituitary gonadotrophins.
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Ali S.T., Shaikh R.N., Ashfaqsiddiqi N. (1993). Serum and urinary levels of pituitary-gonada hormones in insulin-dependent and non-insulin-dependent diabetic males with or without neuropathy. Archives of Andrology, 30:117–123.
American Diabetes Association (ADA) (2003). Tests in glycemia in diabetes. Diabetes Care. 26: 106-108.
Ando, S., Rubens R., Rottiers R. (1984). Androgen plasma levels in male diabetics. Journal of Endocrinology Investigation, 7:21–24.
Arey B.J. (2012). The Role of Glycosylation in Receptor Signaling. In: Glycosylation IntechOpen; 12:273-286.
Azab A. S. (2001). Glycemic control among diabetic patients. Saudi Medical Journal 22(5): 407-409.
Cakir N., Ayvaz G., Arslan M. and Boztepe U. (1996). Plasma Gonadotropin, Sex hormones and prolactin levels in Diabetic patients. Gazi Medical Journal 7: 97-99.
Chen M., Dou J. (2014). Diabetes and gonadal disorders. Journal of Translational Internal Medicine 2(3):119-123.
Dandona P., Dhindsa S. (2011). Hypogonadotropic hypogonadism in type 2 diabetes and obesity Journal of Clinical Endocrinology and Metabolism 96(9):2643-2651 DOI: https://doi.org/10.1210/jc.2010-2724
Dandona P., Mohanty P., Ghanim H., Aljada A., Browne R., Hamouda W., Prahala A., Afzal A., Garg R. (2001). The suppressive effect of dietary restriction and weight loss in the obese on the generation of reactive oxygen species by leukocytes, lipid peroxidation, and protein carbonylation. Journal of Clinical Endocrinology and Metabolism 1:355–362.
Dhindsa S., Prabhakar S., Sethi M., Bandyopadhyay A., Chaudhuri A., Dandona D. (2004). Frequent occurrence of hypogonadism in type 2 Diabetes. Journal of Clinical Endocrinoloy and Metabolism; 89(11):5462-5468.
Ghanim H., Garg R., Aljada A., Mohanty P., Kumbkarni Y., Assian E., Hamouda W., Dandona P. (2001). Suppression of nuclear factor-kappaB and stimulation of inhibitor kappaB by troglitazone: evidence for an anti-inflammatory effect and a potential antiatherosclerotic effect in the obese. Journal of Clinical Endocrinoloy and Metabolism; 86(3):1306-1312.
Harvey R.A. and Ferrier D.R. (2011). Lipid Metabolism; Diabetes Mellitus. In: Lippincott’s Illustrated Reviews: Biochemistry (5th ed). Lippincott Williams & Wilkins Philadelphia 173-244; 337-348
Hundal R., Krssak M., Dufour S., Laurent D., Lebon V., Chandramouli V., Inzucchi S., Schumann W., Petersen K., Landau B., Shulman G. (2000). Mechanism by which metformin reduce blood glucose production in type 2 diabetes. Diabetes; 49(12): 2063-2069.
Kadhim R.J. and Ahmed S.A. (2015). Study the Comparison of Gonadotropin Levels in Diabetes Mellitus Females. Journal of Al-Nahrain University. 18 (3):33-37.
Khaw K.T., Wareham N., Luben R., Bingham S., Oakes S., Welch A., Day N. (2001). Glycated haemoglobin, diabetes, and mortality in men in Norfolk cohort of European Prospective Investigation of Cancer and Nutrition (EPIC-Norfolk). British Medical Journal; 322(7277):15-18.
Kirpichnikov D, McFarlane SI & Sowers JR (2002). Metformin: an update. Annals of Internal Medicine, 137: 25-33.
Natah T.M., Wtwt M.A., Al-Saadi H.K., Al-Saadi A.H, Farhood H.F. (2013). Study the levels of adiponectin, FSH, LH and sex hormones in Type 2 diabetes (NIDDM). Journal of Biology, Agriculture and Healthcare 3:172-181.
Natah T.M. (2014). Serum adiponectin levels in pre-postmenopausal metabolic syndrome women and the correlation with some physio-biochemical parameters. Australian Journal of Basic and Applied Sciences, 8(17): 360-366.
Nathan D.M., Turgeon H., Regan S. (2007). Relationship between glycated haemoglobin levels and mean glucose levels over time. Diabetologia, 50:2239-2244.
Núñez Miguel R., Sanders J., Furmaniak J., Rees Smith B. (2017). Glycosylation pattern analysis of glycoprotein hormones and their receptors. Journal of Molecular Endocrinology; 58 (1):25-41.
Onah C.E, Meludu S.C, Dioka C.E, Onuegbu J.A, Amah U.K, Olisekodiaka M.J, Okwara J.E, Onah C.F and Ezeugwunne I.P. (2013). Pattern of male sex hormones in type 2 diabetic patients in Nnewi, South Eastern Nigeria. Journal of Dental and Medical Sciences. 10 (4):65-70 DOI: https://doi.org/10.9790/0853-1046570
Onung S. I., Young E. E., Ugwu T. E., Fasanmade O. A. (2017). Hypogonadism in Nigerian men with type 2 diabetes mellitus. International Journal of Diabetes in Developing Countries 37 (3): 254–261 DOI: https://doi.org/10.1007/s13410-016-0481-x
Popova E. A., Mironova R. S., Odjakova M. K. (2010) Non-Enzymatic Glycosylation and Deglycating Enzymes. Biotechnology & Biotechnological Equipment; 24(3): 1928-1935 DOI: https://doi.org/10.2478/V10133-010-0066-7
Saudeep D, Sathyavani P, Manak S, Arindam B, Ajay C, Paresh D. (2004). Frequent Occurrence of Hypogonadotropic Hypogonadism in Type 2 Diabetes. Clinical Endocrinology and Metabolism. 89: 5462-5468.
Schmidt AM, Hori O, Brett J, Yan SD, Wautier JL, Stern D. (1994). Cellular receptors for advanced glycation end products: implications for induction of oxidant stress and cellular dysfunction in the pathogenesis of vascular lesions. Arterioscler Thromb.; 14:1521–1528.
Smith P.L., Kaetzel D., Nilson J., Baenziger J.U. (1990). The sialylated oligosaccharides of recombinant bovine lutropin modulate hormone bioactivity. Journal of Biological Chemistry 265:874-881.
Syed I. A. A. (2011). Glycated haemoglobin: past, present and future, are we ready for the change. Journal of Pakistan Medical Association; 61(4): 383-388.
Ulloa-Aguirre A., Midgley A.R., Jr., Beitins I.Z., Padmanabhan V. (1995). Follicle-stimulating isohormones: characterization and physiological relevance. Endocrine Reviews 16:765-787.
Younus H., Anwar S. (2016). Prevention of non-enzymatic glycosylation (glycation): Implication in the treatment of diabetic complication. International Journal of Health Sciences, Qassim University; 10(2): 261-277 DOI: https://doi.org/10.12816/0048818
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