SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF SOME NOVEL 2, 3-DISUBSTITUED QUINAZOLIN-4-(3H)-ONES
DOI:
https://doi.org/10.29121/granthaalayah.v5.i6.2017.2004Keywords:
Quinazoline, Oxadiazole, Quinazolin4(3H)One, Antimicrobial, Anti-InflammatoryAbstract [English]
A new series of 2, 3-disubstituted quinazolin4(3H)one derivatives was synthesized in good yield with the use of different aldehydes and evaluate their antimicrobial and anti-inflammatory activities. Disubstituted quinazolin4(3H)one derivatives were synthesized from Semicarbazide Hydrochloride and semicarbazone as starting materials through oxadiazole as intermediates. This intermediate on reaction with benoxazinone in acidic media, finally converted into corresponding 2, 3-disubstituted quinazolinone derivatives. The synthesized compounds were characterized by their physical properties, Infra-red (IR), nuclear magnetic resonance (NMR), Mass spectroscopic (MS) and elemental analysis and evaluated for biological activities. Ten different analogues of 2, 3-disubstituted quinazolin4(3H)one were successfully synthesized. All the compounds were active against microbial growth and inflammation. They all give good to moderate result on comparison with standard drug. The results reveal that pharmacological activity of quinazolin4(3H)one nucleus can be increased much times on chemical modification. This is advantageous to approaching the treatment of different kinds of severe diseases.
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