IMMUNOHISTOCHEMICAL EXPRESSION OF LATENT MEMBRANE PROTEIN- 1 (LMP-1) AMONG SUDANESE PATIENTS WITH NASOPHARYNGEAL CARCINOMA
DOI:
https://doi.org/10.29121/granthaalayah.v3.i9.2015.2950Keywords:
Epstein-Barr Virus, Immunohistochemistry, LMP1, Nasopharyngeal CarcinomaAbstract [English]
Nasopharyngeal carcinoma (NPC) has a unique and complex etiology that is not completely understood. The distinctive racial/ethnic and geographic distribution of NPC worldwide suggests that both environmental factors and genetic traits contribute to its development. The aims of this study was to investigate the association of LMP-1 EBV in theses tumors in Sudan
To assess the expression pattern of LMP-1 immunohistochemical stain in the different histological types of NPC and to define any association between the expression of LMP-1 with the sex, the age and the histological types of NPC.
Archival formalin-fixed, paraffin-embedded NPC biopsies were evaluated in 35 biopsies for the presence of LMP1 using immunohistochemistry (IHC).
Histologically the cases were, (54%) (19/35) of squamous cell carcinomas subtypes, (26%) (9/35) of undifferentiated squamous cell carcinoma and (20%) (7/35) of keratinized squamous cell carcinomas.LAMP-1 detected in five (5/9) (55%) of undifferentiated squamous cell carcinoma, positive, four (4/19) (21%) of non keratinized squamous cell carcinoma and in two (28%) (2/7) of keratinized squamous cell carcinoma, with (P.value = 0.182), so there is no statistically significant different in the correlation of EBV with histological subtypes of nasopharyngeal carcinoma.
This study confirms that EBV is present in a subset of Sudanese NPC patients. Our results are consistent with those reported by other studies concerning the same NPC endemic risk area and provide original data concerning Sudan.
Downloads
References
Yu MC, Yuan JM. Epidemiology of nasopharyngeal carcinoma. Semin Cancer Biol. 2002;12:421–429. [PubMed] DOI: https://doi.org/10.1016/S1044579X02000858
Stewart BW, Kleihues P. World Cancer Report chap. Head and neck cancer. Lyon: IARC Press; 2003. p. 322.
Seigneurin JM, Fafi-Kremer S, Baccard M, Morand P. Cahier de formation biologiemédicale: Le virus Epstein-Barr et les marqueurs de l'infection. 36 2006. (Fre).
Brennan B. Nasopharyngeal carcinoma. OJRD. 2006;1:23. [PMC free article] [PubMed] DOI: https://doi.org/10.1186/1750-1172-1-23
Busson P, Ooka T, Corbex M. Carcinomesnasopharyngésassociés au virus d'Epstein-Barr : De l'épidémiologie à la thérapeutique et au dépistage. médecine sciences. 2004;20(4):453–457. (Fre). M/S. [PubMed] DOI: https://doi.org/10.1051/medsci/2004204453
Parkin DM, Whelan SL, Ferlay J, Teppo L, Thomas DB, editors. Cancer incidence in five continents, vol. VIII. IARC scientific publications No. 155. Lyon: IARC; 2002.
Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin 2005;55:74–108.CrossRefMedline DOI: https://doi.org/10.3322/canjclin.55.2.74
Ho JHC. Genetic and environmental factors in nasopharyngeal carcinoma. In: Nakahara W, Nishioka K, Hirayama T, Ito Y, editors. Recent advances in human tumor virology and immunology. Tokyo: University of Tokyo Press; 1971. p. 275–95.
Zong YS, Zhang RF, He SY, Qiu H. Histopathologic types and incidence of malignant nasopharyngeal tumors in Zhongshan County. Chin Med J (Engl) 1983;96:511–6. Medline
Levine PH, Connelly RR. Epidemiology of nasopharyngeal carcinoma. In: Wittes RE, editor. Head and neck cancer. New York: John Wiley & Sons; 1985. p. 13–34.
`Shanmugaratnam K, Sobin LH. Histological typing of tumours of the upper respiratory tract and ear. 2nd ed. Berlin: Springer-Verlag; 1991. DOI: https://doi.org/10.1007/978-3-642-84474-4
Yu MC, Henderson BE. Nasopharyngeal cancer. In: Schottenfeld D, Fraumeni JF, Jr., editors. Cancer epidemiology and prevention. 2nd ed. New York: Oxford University Press; 1996. p. 603–18.
Vaughan TL, Shapiro JA, Burt RD, et al. Nasopharyngeal cancer in a low-risk population: defining risk factors by histological type. Cancer Epidemiol Biomarkers Prev 1996;5:587–93. Abstract
Hidayatalla A, Malik MO, El Hadi AE, et al. Studies on nasopharyngeal carcinoma in the Sudan I. Epidemiology and Aetiology. Eur J Cancer ClinOncol. 1983;19:705–10. [PubMed] DOI: https://doi.org/10.1016/0277-5379(83)90001-9
Abuidris DO, Elgaili EM, Elhaj AH, et al. Histopathological patterns of nasopharyngeal carcinoma in Sudan. Saudi Med J. 2008;29:962–5. [PubMed]
Thompson LDR. Update on Nasopharyngeal Carcinoma. Head and Neck Pathol. 2007;1:81–86. [PMC free article] [PubMed] DOI: https://doi.org/10.1007/s12105-007-0012-7
Wei WI, Sham JST. Nasopharyngeal carcinoma. Lancet. 2005;365:2041–2054. [PubMed] DOI: https://doi.org/10.1016/S0140-6736(05)66698-6
Chang ET, Adami HO. The enigmatic epidemiology of nasopharyngeal carcinoma. Cancer Epidemiol Biomarkers Prev. 2006;15(10):1765–1777. [PubMed] DOI: https://doi.org/10.1158/1055-9965.EPI-06-0353
Yuan JM, Wang XL, Xiang, Gao YT, Ross RK, Yu MC. Preserved foods in relation to risk of nasopharyngeal carcinoma in Shanghai, China. Int J Cancer. 2000;85:358–363. [PubMed] DOI: https://doi.org/10.1002/(SICI)1097-0215(20000201)85:3<358::AID-IJC11>3.0.CO;2-E
Tabuchi K, Nakayama M, Nishimura B, Hayashi K, Hara A. Early detection of nasopharyngeal carcinoma. Int J Otolaryngol. 2011 Article ID 638058, 6 pages. [PMC free article] [PubMed] DOI: https://doi.org/10.1155/2011/638058
Abuidris DO, Elgaili EM, Elhaj AH, ElmustafaOM . Histopathological patterns of nasopharyngeal carcinoma in Sudan. 2008 Saudi Med J.; 29(7):962–5.
Ameera A. M. Adam1, Nazik E. Abdullah2, Lamyaa A. M. El Hassan3, Elwaleed M. Elamin4, Muntaser E. Ibrahim1, Ahmed M. El Hassan1. Detection of Epstein-Barr Virus in Nasopharyngeal Carcinoma in Sudanese by in Situ Hybridization. Journal of Cancer Therapy, 2014, 5, 517-522
Xie SH, Yu IT, Tse LA, Mang OW, Yue L. Sex difference in the incidence of nasopharyngeal carcinoma in Hong, 1983-2008: suggestion of a potential protective role of oestrogen.2013 Eur J Cancer ;49 (1):150-5 DOI: https://doi.org/10.1016/j.ejca.2012.07.004
Adham M, Kurniawan AN, Muhtadi AI, Roezin A, Hermani B, Gondhowiardjo S, Tan IB, Middeldorp JM . Nasopharyngeal carcinoma in Indonesia: epidemiology, incidence, signs, and symptoms at presentation. 2012 Chin J Cancer. 31(4):185-96. DOI: https://doi.org/10.5732/cjc.011.10328
Chou J, Lin Y, Kim J, You L, Xu Z, He B, JablonsDM . Nasopharyngeal carcinoma-review of the molecular mechanisms of tumerogenesis. 2008 Head Neck.;30 (7):946–63. DOI: https://doi.org/10.1002/hed.20833
Vera-Sempere F, Burgos J, Botella MS, Morera C . Comparative analysis of Epstein-Barr virus (EBV) detection by nested-PCR and non-isotopic in situ hybridization in nasopharyngeal carcinoma (NPC). 1998 ClinChemActa.; 23; 271(2):119-32. DOI: https://doi.org/10.1016/S0009-8981(97)00209-X
Hørding U, Nielsen HW, Albeck H, Daugaard S. Nasopharyngeal carcinoma: histopathological types and association with Epstein-Barr Virus.1993 Eur J Cancer B Oral Oncol.; 29 B(2):137-9. DOI: https://doi.org/10.1016/0964-1955(93)90036-E
Downloads
Published
How to Cite
Issue
Section
License
With the licence CC-BY, authors retain the copyright, allowing anyone to download, reuse, re-print, modify, distribute, and/or copy their contribution. The work must be properly attributed to its author.
It is not necessary to ask for further permission from the author or journal board.
This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge.
