A NEPHROPROTECTIVE EFFECT OF CARISSA SPINARUM AGAINST GENTAMICIN INDUCED OXIDATIVE NEPHROTOXICITY
DOI:
https://doi.org/10.29121/granthaalayah.v12.i2.2024.5521Keywords:
Carissa Spinarumc Cellular Damage, Oxidative Stress, Kidney FunctionAbstract [English]
One of the most prevalent issues with the kidneys is nephrotoxicity, which happens when the body is exposed to a toxin or medicine. With the growing availability of powerful therapeutic medications such as aminoglycoside antibiotics, chemotherapeutic agents, and nonsteroidal anti-inflammatory drugs (NSAIDs), a variety of pharmaceuticals can have a negative impact on the kidney, leading to acute renal failure, chronic interstitial nephritis, and nephritic syndrome. Ethiopian native Carissa spinarum (Apocynaceae) is traditionally used to treat skin conditions, rheumatism, diarrhoea, chicken pox, and stomachaches. The herbal plant Carissa spinarum possesses antioxidant qualities. The term "nephrotoxicity" describes the detrimental effects that different drugs can have on the kidneys, which can result in damage and dysfunction. This illness offers a serious risk to kidney health and can be brought on by exposure to specific medicines, chemicals, or poisons. Understanding the methods by which these substances affect the structure and function of the kidneys—such as oxidative stress, inflammation, and interference with essential cellular processes—is necessary to comprehend the abstract idea of nephrotoxicity. Nephrotoxicity management also involves establishing prevention and management strategies, identifying, and tracking possible nephrotoxic substances, and managing and preventing nephrotoxicity. All things considered, an abstract comprehension of nephrotoxicity entails investigating the complex pathways and circumstances that lead to renal injury and formulating strategies to lessen or offset these detrimental effects on kidney function.
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AI-Qarawi, A.A., Abdel-Rahman, H., Mousa, H.M., Ali, B.H., & ElMougy, S.A. (2008). Nephroprotective Action of Phoenix Dactylifera in Gentamicine-Induced Nephrotoxicity. Pharmaceutical Biology, 46(4), 227-230. https://doi.org/10.1080/13880200701739322 DOI: https://doi.org/10.1080/13880200701739322
Ali, B. H. (1995). Gentamicin Nephrotoxicity in Humans and Animals: Some Recent Research. General Pharmacology, 26(7), 1477–1487. https://doi.org/10.1016/0306-3623(95)00049-6 DOI: https://doi.org/10.1016/0306-3623(95)00049-6
Bhattacharjee, S.K. (2004). Handbook of Medicinal Plants. Pointer Publishers.
Chopda, M.Z., & Mahajan, R.T. (2009). Wound Healing Plants of Jalgaon District.
Chopra, R.N., Nayar, S.L., & Chopra, I. C. (1999). Glossary of Indian Medicinal Plants. National Institute of Science Communication (CSIR).
Dragsted, L.O., Strube, M., & Larsen, J.C. (1993). Cancer-Protective Factors in Fruits and Vegetables: Biochemical and Biological Background. Pharmacol Toxico, 1, 116-35. https://doi.org/10.1111/j.1600-0773.1993.tb01679.x DOI: https://doi.org/10.1111/j.1600-0773.1993.tb01679.x
Fatima, A., Singh, P.P., Agarwal, P., Irchhaiya, R., Alok, S., & Verma, A. (2013). Treatment of Various Diseases by Carissa Spinarum L. - A Promising Shrub. International Journal of Pharmaceutical Sciences and Research. https://doi.org/10.13040/IJPSR.0975-8232.4(7).1000-03
Gaikwad, K., Pradeep, D., Pushpalata, C., Joshi, Y. M., Kadam, V. (2012). A Review on Some Nephroprotective Medicinal Plants. International Journal of Pharmaceutical Sciences and Research. http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2451-54 DOI: https://doi.org/10.13040/IJPSR.0975-8232.3(8).2451-54
García, B., Barcia, E., Pérez, F., Molina, I. T. (2006). Population Pharmacokinetics of Gentamicin in Premature Newborns. Journal of Antimicrobial Chemotherapy, 58(2), 372–379. https://doi.org/10.1093/jac/dkl244 DOI: https://doi.org/10.1093/jac/dkl244
Gupta, A. K., & Sharma, N. (2004). Tendon Reviews on Indian Medicinal Plants 1- 4 ICMR.
Jado, J. C., Humanes, B., González-Nicolás, M. Á., Camaño, S., Lara, J. M., López, B., Cercenado, E., García-Bordas, J., Tejedor, A., & Lázaro, A. (2020). Nephroprotective Effect of Cilastatin Against Gentamicin-Induced Renal Injury in Vitro and in Vivo Without Altering its Bactericidal Efficiency. Antioxidants (Basel, Switzerland), 9(9), 821. https://doi.org/10.3390/antiox9090821 DOI: https://doi.org/10.3390/antiox9090821
Jain, S.K. (1991). Dictionary of Indian Folkmedicine and Ethnobotany, 1-311.
Khan, M. R., Rizvi, W., Khan, G. N., Khan, R. A., Shaheen, S. (2008). Carbon Tetrachloride-Induced Nephrotoxicity in Rats: Protective Role of Digera Muricata. Journal of Ethnopharmacology, 122, 91-99. https://doi.org/10.1016/j.jep.2008.12.006 DOI: https://doi.org/10.1016/j.jep.2008.12.006
Khare, C.P. (2007). Indian Medicinal Plants Springer Science Business Media LLC. https://doi.org/10.1007/978-0-387-70638-2 DOI: https://doi.org/10.1007/978-0-387-70638-2
Kirtikar, K. R., & Basu, B. D. (1995). Indian Medicinal Plants, (1), 5-6.
Kshirsagar, S.R. & Patil, D.A. (2008). Flora of Dule and Nandurbar District, Maharashtra.
Kshirsagar, S.R., & Patil, D.A. (2008). Flora of Jalgaon District, Maharashtra.
Kumar, M. M., Kushwah, H.K., & Manjusha, R., Ravishankar, B. (2009). An Experimental Evaluation on Nephroprotective Activity of Nagaradi kashaya AYU, 30(1), 55-61.
Mahabale, T.S., & Chaudhari, K.K. (1987). Gazetteer of India. Maharastra state Botany and Flora of Mharashtra.
Moona, A. (2009). Latheef Madhukkal HH, Sithara Ravindran A Review of Nephroprotective Plants. B Pharm Project and Review, 1- 27.
Najeem, P. (2021). A Systematic Review on Nephroprotective Plants. International Journal of Research Publication and Reviews, 2(6), 174-184.
Negi, K., & Asma, M. (2020). Nephroprotective and Therapeutic Potential of Traditional Medicinal Plants in Renal Diseases. Journal of Drug Research in Ayurvedic Sciences, 5(3), 177-185. http://dx.doi.org/10.5005/jdras-10059-0079 DOI: https://doi.org/10.5005/jdras-10059-0079
Prajapathi, P., Sharma, A. K., & Kumar, T. (2003). A Hand Book of Medicinal Plants (Ed. 1st). Agrobios.
Pushpagadan, P., & Kumar, B. (2005). Ethnobotany, CBD, WTO and the Biodiversity Act of India, Ethenobotany, 17, 2-12.
Sundararajan, R., Akhil, B., & Ravindranadh, K. (2014). A Review on Phytoconstituents for Nephroprotective Activity. Gitam Institute of Pharmacy.
Taayade, S. K., & Patil, D. A. (2006). Ethenomedicinal Wisdom of Tribals of Nandurbar Districts (Maharashtra). Natural Product Radiance, 5(1), 64-69.
Yadav, D., Sharma, A. K., Srivastava, S., & Tripathi, Y. B. (2016). Nephroprotective Potential of Standardized Herbals Described In Ayurveda: A Comparative Study. Journal of Chemical and Pharmaceutical Research, 8(8), 419-427.
Yarnell, E. (2007). Abascal Herbs for Relieving Chronic Renal Failure. Alternative and Complementary Therapies, 13(1), 18-23. https://doi.org/10.1089/act.2007.13106 DOI: https://doi.org/10.1089/act.2007.13106
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