RESISTANCE OF KLEBSIELLA PNEUMONIAE TO ANTIBIOTICS OF CAT TREATED AT ANIMAL CLINIC

Safika; Lintang  Wulandari; Arief Purwo Mihardi; Usamah  Afif; Agustin  Indrawati; Rahmat  Hidayat; Titiek  Sunartatie

doi:10.29121/granthaalayah.v10.i12.2022.4932

Authors

Safika Division of Medical Microbiology, School of Veterinary Medicine, and Biomedical Sciences, IPB University, Bogor, Indonesia https://orcid.org/0000-0001-7758-3118
Lintang Wulandari Student of School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia
Arief Purwo Mihardi Division of Internal Medicine, School of Veterinary Medicine, and Biomedical Sciences, IPB University, Indonesia
Usamah Afif Division of Medical Microbiology, School of Veterinary Medicine, and Biomedical Sciences, IPB University, Bogor, Indonesia
Agustin Indrawati Division of Medical Microbiology, School of Veterinary Medicine, and Biomedical Sciences, IPB University, Bogor, Indonesia
Rahmat Hidayat Division of Medical Microbiology, School of Veterinary Medicine, and Biomedical Sciences, IPB University, Bogor, Indonesia
Titiek Sunartatie Division of Medical Microbiology, School of Veterinary Medicine, and Biomedical Sciences, IPB University, Bogor, Indonesia

DOI:

https://doi.org/10.29121/granthaalayah.v10.i12.2022.4932

Keywords:

Animal Clinic, Antibiotic, Antibiotic Resistance, Klebsiella Pneumoniae

Abstract [English]

The antibiotic resistance of Klebsiella pneumoniae has become a global health concern, leading in a reduction in the efficacy of various medications. This study seeks to determine the antibiotic resistance of K. pneumoniae isolated from cats hospitalized in Depok veterinary clinics. Surveys, sample collection, isolation, identification, and antibiotic susceptibility testing comprised the research technique. Seven K. pneumoniae isolates were discovered. There were seven cefotaxime resistant isolates, three amoxicillin resistant isolates, one gentamicin resistant isolate, and one enrofloxacin resistant strain. At the same concentration, one isolate shown intermediate susceptibility to amoxicillin, enrofloxacin, and doxycycline. Sensitivity was demonstrated by six gentamicin isolates, six doxycycline isolates, five enrofloxacin isolates, and three amoxicillin isolates. This information should help veterinarians choose the best efficient antibiotic to treat infections caused by these bacteria.

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References

Adler, K., Radeloff, I., Stephan, B., Greife, H., and Hellmann, K. (2007). Bakteriologischer Und Virologischer Status Bei Katzen Mit Erkrankungen Der Oberen Atemwege (Katzenschnupfenkomplex) [Bacteriological And Virological Status in Upper Respiratory Tract Infections of Cats (Cat Common Cold Complex)]. Berliner Und Münchener Tierärztliche Wochenschrift, 120(3–4), 120–125.

Balouiri, M., Sadiki, M., and Ibnsouda, S. K. (2016). Methods For in Vitro Evaluating Antimicrobial Activity : A Review. Journal of Pharmaceutical Analysis, 6(2), 71–79. https://doi.org/10.1016/j.jpha.2015.11.005. DOI: https://doi.org/10.1016/j.jpha.2015.11.005

Bart, M., Guscetti, F., Zurbriggen, A., Pospischil, A., and Schiller, I. (2000). Feline Infectious Pneumonia: A Short Literature Review and a Retrospective Immunohistological Study on The Involvement of Chlamydia Spp. and Distemper Virus. Veterinary Journal. London, England, 159(3), 220–230. https://doi.org/10.1053/tvjl.1999.0451. DOI: https://doi.org/10.1053/tvjl.1999.0451

Bouza, E., and Cercenado, E. (2002). Klebsiella and Enterobacter : Antibiotic Resistance and Treatment Implications. Seminars in Respiratory Infections, 17(3), 215–230. DOI: https://doi.org/10.1053/srin.2002.34693

Brisse, S., and Duijkeren, E. V. (2005). Identification and Antimicrobial Susceptibility of 100 Klebsiella Animal Clinical Isolates. Veterinary Microbiology, 105(3–4), 307–312. https://doi.org/10.1016/j.vetmic.2004.11.010. DOI: https://doi.org/10.1016/j.vetmic.2004.11.010

Cappuccino, J. G. N., and Sherman. (2014). Microbiology A Laboratory Manual (10th). Pearson. [CLSI] Clinical and Laboratory Standards Institute. (2021). Performance Standards for Antimicrobial Susceptibility Testing, CLSI Supplement, M100. Ed Ke-28. Clinical and Laboratory Standards Institute.

Cowan, S. T., and Steel, S. (1993). Cowan and Steel’s Manual for the Identification of Medical Bacteria. Cambridge University Press. https://doi.org/10.1017/CBO9780511527104. DOI: https://doi.org/10.1017/CBO9780511527104

Epstein, S. E., Mellema, M. S., and Hopper, K. (2010). Airway Microbial Culture and Susceptibility Patterns in Dogs and Cats With Respiratory Disease of Varying Severity. Journal of Veterinary Emergency and Critical Care. San Antonio, TX, 20(6), 587–594. https://doi.org/10.1111/j.1476-4431.2010.00587.x. DOI: https://doi.org/10.1111/j.1476-4431.2010.00587.x

Foster, S. F., Martin, P., Allan, G. S., Barrs, V. R., And Malik, R. (2004). Lower Respiratory Tract Infections in Cats : 21 Cases (1995–2000). Journal of Feline Medicine and Surgery, 6(3), 167–180. https://doi.org/10.1016/j.jfms.2003.11.006. DOI: https://doi.org/10.1016/j.jfms.2003.11.006

Hakvoort, H., Bovenkamp, E., Greenwood-Quaintance, K. E., Schmidt-Malan, S. M., Mandrekar, J. N., Schuetz, A. N., and Patel, R. (2020). Imipenem-Relebactam Susceptibility Testing of Gram-Negative Bacilli by Agar Dilution, Disk Diffusion, and Gradient Strip Methods Compared With Broth Microdilution. Journal of Clinical Microbiology, 58(10), E00695-20. https://doi.org/10.1128/JCM.00695-20. DOI: https://doi.org/10.1128/JCM.00695-20

Harada, K., Shimizu, T., Mukai, Y., Kuwajima, K., Sato, T., Usui, M., Tamura, Y., Kimura, Y., Miyamoto, T., Tsuyuki, Y., Ohki, A., and Kataoka, Y. (2016). Phenotypic and Molecular Characterization of Antimicrobial Resistance In Klebsiella Spp. Isolates from Companion Animals in Japan: Clonal Dissemination of Multidrug-Resistant Extended-Spectrum Β-Lactamase-Producing Klebsiella Pneumoniae. Frontiers in Microbiology, 7, 1021. https://doi.org/10.3389/fmicb.2016.01021. DOI: https://doi.org/10.3389/fmicb.2016.01021

Herring, J. M. (2016). A Novel Placement Technique for Nasogastric and Nasoesophageal Tubes. Journal of Veterinary Emergency And Critical Care. San Antonio, TX, 26(4), 593–597. https://doi.org/10.1111/vec.12474. DOI: https://doi.org/10.1111/vec.12474

Kircik, L. H. (2010). Doxycycline and Minocycline for The Management of Acne: A Review of Efficacy and Safety With Emphasis on Clinical Implications. Journal of Drugs in Dermatology: JDD, 9(11), 1407–1411.

Lappin, M. R., Blondeau, J., Boothe, D., Breitschwerdt, E. B., Guardabassi, L., Lloyd, D. H., Papich, M. G., Rankin, S. C., Sykes, J. E., Turnidge, J., and Weese, J. S. (2017). Antimicrobial Use Guidelines for Treatment Of Respiratory Tract Disease in Dogs and Cats: Antimicrobial Guidelines Working Group of the International Society for Companion Animal Infectious Diseases. Journal of Veterinary Internal Medicine, 31(2), 279–294. https://doi.org/10.1111/jvim.14627. DOI: https://doi.org/10.1111/jvim.14627

Lee, D., Oh, J. Y., Sum, S., and Park, H. M. (2021). Prevalence and Antimicrobial Resistance of Klebsiella Species Isolated from Clinically Ill Companion Animals. Journal of Veterinary Science, 22(2), E17. https://doi.org/10.4142/jvs.2021.22.e17. DOI: https://doi.org/10.4142/jvs.2021.22.e17

Li, Z. J., Zhang, H. Y., Ren, L. L., Lu, Q. B., Ren, X., Zhang, C. H., Wang, Y. F., Lin, S. H., Zhang, X. A., Li, J., Zhao, S. W., Yi, Z. G., Chen, X., Yang, Z. S., Meng, L., Wang, X. H., Liu, Y. L., Wang, X., Cui, A. L. (2021). Etiological and Epidemiological Features of Acute Respiratory Infections In China. Nature Communications, 12(1), 5026. https://doi.org/10.1038/s41467-021-25120-6. DOI: https://doi.org/10.1038/s41467-021-25120-6

Magiorakos, A. P., Srinivasan, A., Carey, R. B., Carmeli, Y., Falagas, M. E., Giske, C. G., Harbarth, S., Hindler, J. F., Kahlmeter, G., Olsson-Liljequist, B., Paterson, D. L., Rice, L. B., Stelling, J., Struelens, M. J., Vatopoulos, A., Weber, J. T., And Monnet, D. L. (2012). Multidrug-Resistant, Extensively Drug-Resistant and Pandrug-Resistant Bacteria : An International Expert Proposal for Interim Standard Definitions for Acquired Resistance. Clinical Microbiology and Infection, 18(3), 268–281. https://doi.org/10.1111/j.1469-0691.2011.03570.x. DOI: https://doi.org/10.1111/j.1469-0691.2011.03570.x

Nikaido, H. (2009). Multidrug Resistance in Bacteria. Annual Review of Biochemistry, 78, 119–146. https://doi.org/10.1146/annurev.biochem.78.082907.145923. DOI: https://doi.org/10.1146/annurev.biochem.78.082907.145923

National Nosocomial Infections Surveillance System [NNIS] (2004). National Nosocomial Infections Surveillance (NNIS) System Report, Data Summary from January 1992 Through June 2004, Issued October 2004. American Journal of Infection Control, 32(8), 470–485. https://doi.org/10.1016/s0196655304005425. DOI: https://doi.org/10.1016/j.ajic.2004.10.001

Podschun, R., and Ullmann, U. (1998). Klebsiella Spp. as Nosocomial Pathogens: Epidemiology, Taxonomy, Typing Methods, and Pathogenicity Factors. Clinical Microbiology Reviews, 11(4), 589–603. https://doi.org/10.1128/CMR.11.4.589. DOI: https://doi.org/10.1128/CMR.11.4.589

Quinn, P. J., Markey, B. K., Leonard, F. C., Fitzpatrick, E. S., Fanning, S., And Hartigan, P. J. (2011). Veterinary Microbiology and Microbial Disease. Blackwell Publishing. https://doi.org/10.1016/j.vetmic.2012.06.004. DOI: https://doi.org/10.1016/j.vetmic.2012.06.004

Schulz, B. S., Wolf, G., and Hartmann, K. (2006). Bacteriological and Antibiotic Sensitivity Test Results in 271 Cats With Respiratory Tract Infections. Veterinary Record, 158(8), 269–270. https://doi.org/10.1136/vr.158.8.269. DOI: https://doi.org/10.1136/vr.158.8.269