DIFFERENTIAL EXPRESSION OF MICRORNA IN GENERALIZED ANXIETY DISORDER AND ITS ASSOCIATION WITH SOCIAL SUPPORT

Lingming Kong; Xiaoli Zhu; Wei Niu; Liyi Zhang

doi:10.29121/granthaalayah.v9.i9.2021.4265

Authors

Lingming Kong Prevention and Treatment Center for Psychological Diseases, No. 904 Hospital of Chinese PLA, Changzhou 213003, Jiangsu, China
Xiaoli Zhu Prevention and Treatment Center for Psychological Diseases, No. 904 Hospital of Chinese PLA, Changzhou 213003, Jiangsu, China
Wei Niu Department of Rehabilitation, No.904 Hospital of Chinese PLA, Changzhou, Jiangsu 213003, China
Liyi Zhang Prevention and Treatment Center for Psychological Diseases, No. 904 Hospital of Chinese PLA, Changzhou 213003, Jiangsu, China

DOI:

https://doi.org/10.29121/granthaalayah.v9.i9.2021.4265

Keywords:

GAD, MicroRNA, Social Support, Personality

Abstract [English]

To explore the differential expression of microRNA (miRNA, miR-) and its correlation with social support and personality in Generalized Anxiety Disorder (GAD) patients. A total of 80 GAD patients and 80 control participants were selected from our serial study samples to be tested for microarray analysis, and real time quantitative Polymerase Chain Reaction (qRT-PCR) verification was carried out in both patient group and control group. Correlation between miRNA expression and social support were also carried out. According to microarray analysis, 6 miRNAs were differentially expressed between patient group and control group, with miR-4505, miR-4484, miR-4674, miR-501-3p and miR-663 up-regulated, and miR-1301 down-regulated; qPCR verification revealed that 5 miRNAs (miR-1301, miR-4484, miR-4674, miR-501-3p, miR-663, miR-4505) were significantly up-regulated and the expression of miRNA-1301 down-regulated; the expression of miRNA-1301 was significantly related to social support in GAD patients. In conclusions, comprehensive factors, including miRNA regulation, social support may be involved into the aetiology of GAD.

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