ANTIBIOTIC USE IN SLOVENIAN HOSPITALS

Authors

  • Tatjana Pokrajac Chair of public health, Medical Faculty, University Ljubljana, Slovenia
  • Milan Čižman Clinic for infectious diseases and febrile state, University Clinical Centre Ljubljana, Slovenia
  • Bojana Beovič Clinic for infectious diseases and febrile state, University Clinical Centre Ljubljana, Slovenia

DOI:

https://doi.org/10.29121/granthaalayah.v7.i11.2020.364

Keywords:

Antibiotics, Case Mix Index, Defined Daily Dose, General Hospitals, University Medical Centres

Abstract [English]

Abstract: Motivation/Background: Antibiotics are commonly overused and misused what increase the emergence of resistant organisms, side- effects and costs. To assess the appropriate use of antibiotics many methods are available. The aim of the present study is to find correlation between antibiotic use and case mix index (CMI) in Slovenian hospitals.


Method: In retrospective study (in the years between 2004 and 2013) we correlated the total consumption of antibiotics for systemic use and CMI. Weighted linear regression test analysis was performed to determine correlation between defined daily dose (DDD) / 100 admissions and DDD / 100 bed-days and CMI.


Results: The total antibiotic consumption in all included hospitals was in mean 317.69 DDD / 100 admissions and 58.88 DDD / 100 bed days, respectively. CMI range were from 1.25 to 3.55. A significant correlation between consumption expressed in DDD / 100 admissions and CMI (p = 0.028) and DDD / 100 bed days and CMI (p =0.008) was found. Conclusions: Thus, detailed analysis of correlations between DDD of antibiotics and CMI may constitutes a proper use of antibiotics.

Downloads

Download data is not yet available.

References

Ansari F, Ernetll M, Goossen H, Davey P. The European Surveillance of Aantimicrobial Consumption (ESAC) Point-Prevalence Survey of Antibacterial Use In 20 European Hospitals In 2006. Clinical Infectious Diseases. Vol. 49, No. 10, November 2009, 1496-504. DOI: https://doi.org/10.1086/644617

Vander Stichele RH, Elseviers MM, Ferech M, et al. Hospital Consumption Of Antibiotics In 15 European Countries: Results Of The ESAC Retrospective Data Collection 1997-2002. Journal of Antimicrobial Chemotherapy. Vol. 58, No. 1, July 2006, 159-67. DOI: https://doi.org/10.1093/jac/dkl147

Dumartin C, L' Heriteau F, Pefau M, Bertrand X, Jarno P, et al. Antibiotic Use In 530 French Hospitals: Results from A Surveillance Network At Hospital And Ward Levels In 2007. Journal of Antimicrobial Chemotherapy. Vol. 65, No. 9, September 2010. DOI: https://doi.org/10.1093/jac/dkq228

Pokrajac T. Ekonomsko Breme Pogostih Nalezljivih Bolezni V Sloveniji. Diplomsko delo. Ljubljana: Medicinska fakulteta; 2014.

Pokrajac T, Truden-Dobrin P, Beovič B, Čižman M. Pogostnost Ambulantnih In Bolnišničnih Obravnav Ookužb V Sloveniji. V: Beović B, Strle F, Čižman M, eds. Infektološki simpozij. Ljubljana: Sekcija za kemoterapijo; 2008.

ECDC. Annual Epidemiological Report Reporting On 2011 Surveillance Data And 2012 Epidemic Intelligence Data 2013. Stockholm: ECDC; 2013.

Kritsotakis E, Gikas A. Surveillance of Antibiotic Use In Hospitals: Methods, Trends And Targets. Clinical of Microbiology Infection. Vol. 12, No.8, September 2006, 12: 701-4. DOI: https://doi.org/10.1111/j.1469-0691.2006.01415.x

Kuster SP, Ruef C, Bollinger AK, et al. Correlation Between Case Mix Index And Antibiotic Use In Hospitals. Journal Of Antimicrobial Chemotherapy. Vol. 62, No. 4, October 2008; 837-42 DOI: https://doi.org/10.1093/jac/dkn275

Willemsen I, Groenhuijzen A, Bogaers D, et al. Appropirateness Of Antimicrobial Therapy Measured By Repeated Prevalence Surveys. Antimicrobial Agents Chemotherapy. Vol. 51, No. 3, March 2007, 864–867. DOI: https://doi.org/10.1128/AAC.00994-06

Čižman M, Beovič B. Kako Predpisujemo Protimikrobno Zdravila V Bolnišnicah? Ljubljana: Sekcija za kemoterapijo, 2007.

WHO Collaborating Centre For Drug Statistic Methodology. ATC Index with DDDs.

Available January 10, 2016 from: http://www.whocc.no/.

Zdravstveni Statistični Letopis 2013. Nacionalni Nnštitut Za Javno Zdravje RS, Ljubljana 2013.

Zbirka Bolnišničnih Obravnav (Združene Eepizode Hospitalizacij Po Diagnozah) 2004 - 2013). Nacionalni Inštitut Za Javno Zdravje RS, Ljubljana 2005 – 2014.

Zbirka Bolnišničnih Obravnav Istega Tipa (SPP) Zaradi Bolezni 2004 – 2013. Nacionalni Inštitut Za Javno Zdravje RS, Ljubljana 2005 – 2014.

Čižman M. Poraba Antibiotikov V Slovenskih Bolnišnicah V Letu 2011. ISIS. Vol. 1l, 2012, 64-6.

Kwint HM, Van Der Linden PD, Roukens MM, et al. Intensification of Antibiotic Use Within Acute Care Hospitals In The Netherldands. Journal of Antimicrobial Chemotherapy. Vol 67, No. 9, May 2012, 2283-8. DOI: https://doi.org/10.1093/jac/dks190

Mednarodna Klasifikacija Bolezni In Sorodnih Zdravstvenih Problemov Za Statistične Namene, Deseta Revizija (MKB-10). Ljubljana: Inštitut Za Varovanje Zdravja Republike Slovenije, 1995.

Simonsen L, Conn LA, Pinner RW, et al. Trends in Infectious Disease Hospitalization In The United States, 1980 – 1994. Archives Of Internal Medicine. Vol. 158, No. 17, September 1998, 1923-8. DOI: https://doi.org/10.1001/archinte.158.17.1923

Kern Wv, Fellhauter M, Hug M, et al. Recent Antibiotic Use In German Acute Care Hospital – From Benchmarking To Improve Prescribing And Qulity Care. Deutsche Medizinische Wochenschrift. Vol. 140, No. 23, November 2015, 237-46.

Čižman M. Slovenian Consumption Study Group. Nationwide Hospital aantibiotic Consumption in Slovenia. Journal of Antimicrobial Chemotherapy. Vol. 66, No. 9, June 2011, 2189-91. DOI: https://doi.org/10.1093/jac/dkr263

Serdt M. Sensitivity and Specificity of The Method Used for Ascertainment Of Healthcare-Associated Infections In The Second Slovenian National Prevalence Survey. Slovenian Jornal of Public Health. Vol. 55, No. 4, July 2016, 248-255. DOI: https://doi.org/10.1515/sjph-2016-0034

Klavs I. The Prevalence of And Risk Factors for Healthcare Associated Infections In Slovenia. Slovenian Journal of Public health. Vol. 55, No. 4, July 2016, 239-47. DOI: https://doi.org/10.1515/sjph-2016-0033

Polk RE, Hohmann SF, Medvdev S, Ibrahim O. Benchmarking Risk-Adjusted Adult Antibacterial Drug Use in 70 US Academic Medical Center Hospitals. Clinical Infectious Diseases. Vol. 53, No. 11, December 2011, 1100-10. DOI: https://doi.org/10.1093/cid/cir672

Berrington A. Antimicrobial Prescribing In Hospitals: Be Careful What You Measure. Journal Of Antimicrobial Chemother. Vol. 5, No. 1, January 2010, 163-8. DOI: https://doi.org/10.1093/jac/dkp399

Jereb M. Antibiotično Zdravljenje Na Oddelkih Zza Intenzivno Zdravljenje V Sloveniji. Zbornik Predavanj. 20. Simpozij Intenzivne Medicine In 17. Seminar Intenzivne Medicine Za Medicinske Sestre In Zdravstvene Tehnike. Zbornik Predavanj: Bled; 2011.

EDCD. Surveillance of Antimicrobial Consumption In Europe 2012. Stockholm: ECDC; 2014

Downloads

Published

2019-11-30

How to Cite

Pokrajac, T., Čižman, M., & Beovič, B. (2019). ANTIBIOTIC USE IN SLOVENIAN HOSPITALS. International Journal of Research -GRANTHAALAYAH, 7(11), 249–258. https://doi.org/10.29121/granthaalayah.v7.i11.2020.364