EVALUATION OF THYROID DISORDERS IN SUDANESE PATIENTS WITH DOWN SYNDROME
Down syndrome is the most common life compatible chromosomal disorder responsible for the majority of mental retardation and deaths in infancy and childhood. The current study intended to evaluate the thyroid disorders in Sudanese patients with Down syndrome by assessment of thyroid function tests (T3, T4 & TSH) . It was descriptive case control study, carried out in Khartoum, the capital of Sudan, from March to July 2018. It included fifty (50) participants, thirty (30) of them as case group with Down syndrome and twenty (20) normal healthy subjects as control group. Their ages ranged from seven (7) to twenty eight (28) years.
The study findings showed significant variation in TSH level with mean (2.66 ), (1.67 ) in case and control group respectively with P. value (0.001). There was also significant variation when compared children and adults mean TSH level (1.88 ),(2.59 ) with P. value of (0.03). There was insignificant differences in T3 level with mean SD(1.04 .32),(1.11 ) between case and control group respectively with P. value of (0.08) . There was also insignificant difference in T4 level with mean (6.09 ),(6.40 ) in case and control group respectively with P. value of (0.7). There were also insignificant differences in T4 and T3 levels between the age groups. As regard to the gender of the patients, there were insignificant differences of TSH, T4, and T3
Antonarakis SE, Lyle R, Dermitzakis ET, Reymond A, Deutsch S. Chromosome 21 and down syndrome: from genomics to pathophysiology. Nature reviews genetics. 2004;5(10): 725. DOI: https://doi.org/10.1038/nrg1448
Pentao L, Wise CA, Chinault AC, Patel PI, Lupski JR. Charcot–Marie–Tooth type 1A duplication appears to arise from recombination at repeat sequences flanking the 1.5 Mb monomer unit. Nature genetics. 1992;2(4):292. DOI: https://doi.org/10.1038/ng1292-292
Cutler AT, Benezra-Obeiter R, Brink SJ. Thyroid function in young children with Down syndrome. American Journal of Diseases of Children. 1986;140(5):479-83.
Prasher V, Gomez G. Natural history of thyroid function in adults with Down syndrome–10‐year follow‐up study. Journal of Intellectual Disability Research. 2007;51(4):312-7. DOI: https://doi.org/10.1111/j.1365-2788.2006.00879.x
Moosa S, Segal DG, Christianson AL, Gregersen NE. Thyroid dysfunction in a cohort of South African children with Down syndrome. SAMJ: South African Medical Journal. 2013;103(12):966-70. DOI: https://doi.org/10.7196/SAMJ.7111
Prasher V, Ninan S, Haque S. Fifteen‐year follow‐up of thyroid status in adults with Down syndrome. Journal of Intellectual Disability Research. 2011;55(4):392-6. DOI: https://doi.org/10.1111/j.1365-2788.2011.01384.x
King K, O’Gorman C, Gallagher S. Thyroid dysfunction in children with Down syndrome: a literature review. Irish journal of medical science. 2014;183(1):1-6. DOI: https://doi.org/10.1007/s11845-013-0994-y
King K, O'Gorman C, Gallagher S. An audit of the management of thyroid disease in children with Down syndrome. Irish medical journal. 2014.
Melinda J. Pierce, Stephen H. LaFranchi, Joseph D. Pinter. Characterization of Thyroid Abnormalities in a Large Cohort of Children with Down Syndrome. Horm Res Paediatr .2017;87: 170–178. DOI: https://doi.org/10.1159/000457952
Nitash Zwaveling-Soonawala, M Emma Witteveen, Jan Pieter Marchal, Femke C C Klouwer, Nadine A Ikelaar, Anne M J B Smets, Rick R van Rijn, Erik Endert, Eric Fliers and A S Paul van Trotsenburg. Early thyroxine treatment in Down syndrome and thyroid function later in life. European Journal of Endocrinology. May 2017; Volume 176: Issue 5. Pages: 505–513. DOI: https://doi.org/10.1530/EJE-16-0858
Copyright (c) 2020 Ayman FatahAlrahman, A. Babiker, Mosab .O. Khalid, Haghamad Allzain Allzain
This work is licensed under a Creative Commons Attribution 4.0 International License.