EVALUATION OF THYROID DISORDERS IN SUDANESE PATIENTS WITH DOWN SYNDROME

  • Ayman FatahAlrahman Department of Clinical Chemistry – Faculty of Medical Laboratory Sciences -Shendi University-Sudan
  • A. Babiker Department of Clinical Chemistry – Faculty of Medical Laboratory Sciences -Shendi University-Sudan
  • Mosab .O. Khalid Department of Clinical Chemistry – Faculty of Medical Laboratory Sciences -Shendi University-Sudan
  • Haghamad Allzain Assistant Professor In The Department Of Biochemistry- Faculty Of Medicine- Shendi University –Sudan https://orcid.org/0000-0002-2812-553X
Keywords: Down Syndrome, Hypothyroidism, Thyroxine, T3, T4, TSH

Abstract

Down syndrome is the most common life compatible chromosomal disorder responsible for the majority of mental retardation and deaths in infancy and childhood. The current study intended to evaluate the thyroid disorders in Sudanese patients with Down syndrome by assessment of thyroid function tests (T3, T4 & TSH) . It was descriptive case control study, carried out in Khartoum, the capital of Sudan, from March to July 2018. It included fifty (50) participants, thirty (30) of them as case group with Down syndrome and twenty (20) normal healthy subjects as control group. Their ages ranged from seven (7) to twenty eight (28) years.

The study findings showed significant variation in TSH level with mean  (2.66   ), (1.67 ) in case and control group respectively with P. value (0.001). There was also significant variation when compared children and adults mean TSH level (1.88   ),(2.59 ) with P. value of (0.03). There was insignificant differences in T3 level with mean  SD(1.04 .32),(1.11 ) between case and control group respectively with P. value of (0.08) . There was also insignificant difference in T4 level with mean  (6.09 ),(6.40 ) in case and control group respectively with P. value of (0.7). There were also insignificant differences in T4 and T3 levels between the age groups. As regard to the gender of the patients, there were insignificant differences of TSH, T4, and T3

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Published
2020-12-24
How to Cite
FatahAlrahman, A., Babiker, A., Khalid, M. .O., & Allzain, H. A. (2020). EVALUATION OF THYROID DISORDERS IN SUDANESE PATIENTS WITH DOWN SYNDROME . International Journal of Research -GRANTHAALAYAH, 8(12), 24-29. https://doi.org/10.29121/granthaalayah.v8.i12.2020.2523