TOXOPLASMOSIS: SEROLOGIC PROFILE OF PREGNANT WOMEN AT THE BRAZZAVILLE UNIVERSITY CENTRE HOSPITAL (CHUB)

Sékangué Obili G; Ossibi Ibara BR; Potokoué Mpia NSB; Adoua Doukaga T; Itoua C

doi:10.29121/granthaalayah.v7.i9.2019.611

Authors

Sékangué Obili G Parasitology Mycology Department, Brazzaville University Centre Hospital (CHUB), Congo - Brazzaville
Ossibi Ibara BR Infectious Diseases Department, Brazzaville University Centre Hospital (CHUB), Congo - Brazzaville
Potokoué Mpia NSB Gynaecology Obstetric Department, Brazzaville University Centre Hospital (CHUB), Congo - Brazzaville
Adoua Doukaga T Infectious Diseases Department, Brazzaville University Centre Hospital (CHUB), Congo - Brazzaville
Itoua C Gynaecology Obstetric Department, Brazzaville University Centre Hospital (CHUB), Congo - Brazzaville

DOI:

https://doi.org/10.29121/granthaalayah.v7.i9.2019.611

Keywords:

Toxoplasmosis, Serologic Profile, Pregnant Women, Brazzaville, CHUB

Abstract [English]

Introduction: Toxoplasmosis is a disease caused by an obligate intracellular coccidia Toxoplasma gondii, which is transmitted by cats. In pregnant women, it is a concern because of the severe complications to the foetus. The objective of this study is to determine the toxoplasma serologic profile in pregnant women at the Brazzaville University Centre Hospital (CHUB).

Materials and Methods: This is a cross-sectional study from September 2015 to March 2016 (6 months) which includes sera from pregnant women received at the Parasitology Mycology laboratory of the CHUB for Toxoplasma serology. Immunoglobulins G and M searches were done by immuno-analysis (Biomerieux, Mini-Vidas technology). The data was analysed by the IBM SPSS version 20 software. The comparisons of proportion is done by the khi 2 test. The level of significance of statistical data were fixed at 5%.

Results: The mean age of pregnant women included in our study was 27, 8+/- 6,84 with the extremes ages of 15 and 44 years.

Toxoplasma seroprevalence in this study is 47,2% (68/144). The types of immunoglobulins (Ig) retrieved were IgG alone in 45,1% of cases (65/144), IgG associated to IgM in 2,8% of cases (4/144). Serological profiles were: no immunity (52,1%) immunised (41%), recent infection (1,4%) active infection (2,8%) equivocal result (2,8%).

Conclusion: Toxoplasmosis is a zoonosis which represents a real public health issue in our environment, even when the level of immunised pregnant women seems high.

Downloads

Download data is not yet available.

References

Gentilini M. Médecine tropicale : Flammarion Médecine Sciences; 5ème édition. Paris: 152-8.1993

Bamba S, Some DA, Chemla C. et al. Analyse sérologique de la toxoplasmose pergravidique: évaluation des risques et perspectives du dépistage prénatal au centre hospitalier universitaire de Bobo Dioulasso au Burkina Faso; Pan Afr Med J 2012 ; 12 :42-8.

Diallo S, Ndir O, Dieng Y et al. Séroprévalence de la toxoplasmose à Dakar (Sénégal) en 1993 : étude chez des femmes en période de procréation. Cahiers Santé 1996; 6:102-6.

Shimelis T, Tebeje M, Tadesse E and al. Seroprevalence of latent Toxoplasma gondii infection among HIV infected and HIV-uninfected people in Addis Ababa Ethiopia: a comparative cross-sectional study. BMC Res Notes 2009; 2: 213. DOI: https://doi.org/10.1186/1756-0500-2-213

Cimon B, Penn P, Brun S, Chabasse D. Comment résoudre les difficultés du sérodiagnostic de la toxoplasmose chez la femme enceinte ? Immuno-analyse & Biologie spécialisée 2002; 17: 143–7. DOI: https://doi.org/10.1016/S0923-2532(02)01183-3

Makuwa M., Lecko M., Nsimba B., et al. Toxoplasmose et la femme enceinte au Congo : bilan de 5 ans de dépistage (1986-1990). Med Afr Noire 1992; 39(2): 493-5.

Yobi D, Piarroux R, L’Ollivier C, et al. Toxoplasmosis among pregnant women: High seroprevalence and risk factors in Kinshasa, Democratic Republic of Congo. Asian Pac J Trop Biomed 2014; 4(1): 69-74. DOI: https://doi.org/10.1016/S2221-1691(14)60211-2

Ndiaye IM, Diongue K, Seck MC et al. Séroprévalence de la toxoplasmose chez les femmes enceintes au CHU Aristide Le Dantec de Dakar. Méd Afr Noire 2016; 63(9): 515-21.

Ogouyemi- Hounto A, Agbayahoun-Chokki F, Sissintosavi de Tove Y et al. Evaluation of a rapid diagnostic test in the diagnosis of toxoplasmosis in pregnant women in Cotonou (Bénin). Bull Soc Path Exot. 2014; 107(2): 85-9. DOI: https://doi.org/10.1007/s13149-014-0355-8

Antoniou M, Tzouvali H, Sifakis S and al. Incidence of toxoplasmosis in 5532 pregnant women in Crete, Greece: management of 185 cases at risk. J Gynecol Obstet BiolReprod2004; 117: 138-43. DOI: https://doi.org/10.1016/j.ejogrb.2004.03.001

El Mansouri B, Rhajaoui M, Sebti F, et al. Séroprévalence de la toxoplasmose chez la femme enceinte dans la ville de Rabat au Maroc. Bull Soc Pathol Exot 2007; 100(4): 289-90.

Nabias R, Ngouamizokou A, Migot-Nabias F et al. Enquête sérologique sur la toxoplasmose chez les consultantes du centre de P.M.I. de Franceville (Gabon). Bull Soc Pathol Exot 1998 feb; 91: 318-20.

Lo G, Diouf N, Faye B et al. Prévalence de la toxoplasmose chez les femmes enceintes au laboratoire de l’hôpital militaire de Ouakam, Dakar. Med Afr Noire 2012; 59(7): 364-8.

Messerer L, S. Bouzbid S, E. Gourbdji et al. Séroprévalence de la toxoplasmose chez les femmes enceintes dans la wilaya d’Annaba, Algérie. Rev Epidémiol Santé Publique, 2014; 62: 160-5. DOI: https://doi.org/10.1016/j.respe.2013.11.072

Awoke K, Nibret E, Munshea A. Sero-prevalence and associated risk factors of Toxoplasma gondii infection among pregnant women attending antenatal care at Felege Hiwot Referral Hospital, northwest Ethiopia. Asian Pac J Trop Med, 2015; 8(7): 549-54. DOI: https://doi.org/10.1016/j.apjtm.2015.06.014

Adou-Bryn KD, Ouhon J, Nemer J et al. Dépistage sérologique de la toxoplasmose acquise chez les femmes en âge de procréer dans la commune de Yopougon (Abidjan, Côte d’Ivoire). Bull Soc Pathol Exot. 2004; 97(5): 345-8.