EFFECTS OF MODERATE-INTENSITY EXERCISE TRAINING ON STRESS OXIDATIVE MARKER: MALONDIALDEHYDE AND SUPEROXIDE DISMUTASE ACTIVITY IN ABDOMINAL AORTA OF JUVENILE RATS
DOI:
https://doi.org/10.29121/granthaalayah.v5.i12.2017.477Keywords:
Moderate Intensity Aerobic Exercise Trainin, Juvenile, Stress Oxidative Marker, MDA, SOD, Abdominal AortaAbstract [English]
To improve cardiovascular health, the WHO recommends 60 minutes of frequent moderate intensity physical activity in childhood. ACSM also recommends physical activity 30 minutes moderate activity or 30 minutes vigorous intensity, 3-4 times per week. However, limited data concerned in exercise starting from childhood effect to oxidative stress marker in vascular. Therefore the long-term effects of moderate intensity aerobic exercise training in early age on the cardiovascular, specifically on vascular stress oxidative marker needed to be studied. This study was conducted on male Wistar rats aged 3 weeks (60-70 grams), randomly allocated into 2 groups: 1) control group and 2) training group. Aerobic exercise training was conducted for 8 weeks on treadmill with age-dependent speeds. Training was intermittently 5 days each week for 20 minutes. Vascular oxidative stress marker was analyzed by measuring the level of malondialdehyde (MDA) and superoxide dismutase (SOD) activity on the abdominal aorta. Both the levels of MDA and SOD activity tended to increase in training group compared to the control group. The resuls of this study showed that long-term effects of moderate intensity aerobic exercise training in juvenile tended to increase the levels of MDA and specific SOD activity in the abdominal aorta tissues.
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References
Cohen, M.S. (2004). Fetal and childhood onset of adult cardiovascular diseases. Pediatr Clin N Am, 51: 1697-1719.
Celermajer, D.S., Ayer, J.G.J. (2006). Childhood risk factors for adult cardiovascular disease and primary prevention in childhood. Heart, 92: 1701-6.
Li, H., Horke, S., Feorstermann,U. (2014). Vascular oxidative stress, nitric oxide and atherosclerosis. Atherosclerosis, 237: 208-19.
Madamanchi, N.R., Vendrov, A., Tunge, M.S.(2005). Oxidative stress and vascular disease. Arterioscler Thromb Vasc Biol, 25: 29-38.
Stocker, R., Keaney, J.F. (2004). Role of oxidative modifications in atherosclerosis. Physiol Rev, 84: 1381-1478.
Vogiatzi, G., Tousoulis, D., Stefanadis, C.(2009). The role of oxidative stress in atherosclerosis. Hellenic J Cardiol, 50: 402-9.
Silva, A.S., Zanesco, A. (2010). Physical exercise, β-adrenergic receptors, and vascular response. J Vasc Bras, 9(2), 47-56. DOI: https://doi.org/10.1590/S1677-54492010000200007
Roque, F.R., Briones, A.M., García-Redondo, A.B., Galán, M., Martínez-Revelles, S., Avendaño, M.S., et al. (2013). Aerobic exercise reduces oxidative stress and improves vascular changes of small mesenteric and coronary arteries in hypertension. British Journal of Pharmacology, 168: 686-703.
De Moraes, C., Davel, A.P.C., Rossoni, L.V., Antunes, E., Zanesco, A. (2008).Exercise training improves relaxation response and SOD-1 expression in aortic and mesenteric rings from high caloric diet-fed rats. BMC Physiolog, 8: 1-12.
Husain K.(2004). Interaction of regular exercise and chronic nitroglycerin treatment on blood pressure and rat aortic antioxidants. Biochimica et Biophysica Acta 1688, 18-25. DOI: https://doi.org/10.1016/j.bbadis.2003.10.002
World Health Organization.(2005). Global recommendations on physical activity for health. Switzerland: WHO.
Roberts, M.D., Company, J.M., Brown, J.D., Toedebusch, R.G., Padilla, J., Jenkins, N.T., et al.(2012). Potential clinical translation of juvenile rodent inactivity models to study the onset of childhood obesity. Am J Physiol Regul Integr Comp Physiol, 303: R247-R258.
Silva, A.N., Lima, L.C.F.(2015). The association between physical exercise and reactive oxygen species (ROS) production. J Sports Med Doping Stud, 5:1.
Kahlmeier,S., Alpiger,P., Martin, B.W.(2012). National recommendations for health-enhancing physical activity: the situation for Switzerland in 2011 and options for further developments. Sportmedizin und sporttraumatologie, 60 (3), 96-101.
American College of Sports Medicine. ACSM’s guidelines for exercise testing and prescription. 8th ed. Lippincott Williams & Wilkins, a Wolters Kluwer business.
Hsu, Y.C., Chen, H.I., Kuo, Y.M., Yu, L., Huang, T.Y., Chen, S.J., et al. (2011). Chronic treadmill running in normotensive rats resets the resting blood pressure to lower levels by upregulating the hypothalamic GABAergic system. J Hypertens, 29: 2339-48.
William. (2013). Perubahan aktivitas listrik jantung pada tikus yang diberi latihan fisik aerobik serta henti latih [tesis]. Jakarta: Universitas Indonesia.
Flurkey, K., Currer, J.M., Harrison, D.E. (2007). The mouse in aging research: In the mouse in biomedical research 2nd edition. Fog JG et al, editors. American College Laboratory Animal Medicine. Burlington: Elsevier, 637-72.
Ahmadiash, N., Hesari, F.S., Sales, E.K. (2014). Cerebellum and reelin under chronic treadmill exercise conditions in male rats. Int J Adv Biol Biom Res, 2(1): 170-5.
Nasca, M.M., Zhang, R., Super, D.M., Hazen, S.L., Hall,H.R. (2010). Increased oxidative stress in healthy children following an exercise program: a pilot study. J Dev Behav Pediatr, 31(5): 386-92.
Sahin, S.K. (2013). Increase oxidative stress inflammatory response in juvenile swimmers after a 16-week swimming training. European Journal of Experimental Biology, 3(3): 211-7.
Schneider, C.D., Oliveira, A.R. (2004). Oxygen free radicals and exercise: mechanisms of synthesis and adaptation to the physical training. Rev Bras Med Esporte, 10: 314-8.
Plowman,S.A., Smith, D.L.(2011). Exercise physiology: for health, fitness, and performance. 3rd ed. China: Lippincott Williams & Wilkins, a Wolters Kluwer business.
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