EVALUATING COMMON HEMATOLOGICAL AND BIOCHEMICAL BIOMARKERS AS PREDICTORS FOR ISCHEMIC HEART DISEASES AMONG ADULT SUDANESE PATIENTS
DOI:
https://doi.org/10.29121/granthaalayah.v10.i2.2022.4491Keywords:
Ischemic Heart Diseases, Biomarkers, Inflammatory Markers, AtherosclerosisAbstract [English]
Background: Ischemic heart diseases are the leading cause of death worldwide. It accounts for (20.07%) of total deaths with a death rate of 279.01 per 100.000 population. Being multifactorial in origin, the causes, diagnosis, prevention, control, and/or treatment of IHD remain active fields of biomedical research with considerable emphasis on the relativity of various risk factors and IHD.
Methods: This is a descriptive cross-sectional case-control prospective analytical study to evaluate the hematological and biochemical predictors in ischemic heart disease patients in Shendi locality, River Nile, State Sudan. The study excluded all patients with comorbidities that might affect the results of biomarkers.
Results: The mean values of Hb, PCV, RBCs, MCV, MCH, MCHC, RDW in case group were (12.3 g/dl), (37.7%), (4.2x1012/l), (87.9 fl), (28.9 pg), (32.9 g/dl) and (16.5) respectively and mean of TWBCs, Neutrophil, lymphocyte, monocyte, eosinophil, basophil, platelet count and MPV of (8.4 x 109 /l), (66.6%), (25%), (5.9%), (2.5%), (0%), (301.9 x 109 /l) and (8.4) respectively. The mean of hsCRP, D.dimer in case group were (5.896 mg/l), (1247.4 ng/ml), respectively. The case group had mean range of urea and creatinine (57.68 mg/dl) and (1.55 mg/dl) respectively, and mean of (Na+), (K+) and (Ca2+) of (136.1 mmol/l), (3.87 mmol/l) and (9.73 mg/dl) respectively.
Conclusion: When compared to healthy individuals in the control group, the case group had lower Hb, PCV, red cells indices, serum sodium (Na+), potassium (K+), and calcium (Ca2+) levels. And higher levels of TWBCs, Neutrophil, platelet, MPV, Serum hsC-reative protein, plasma D.dimer, b.urea, and serum creatinine
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References
Batstone G (1997). Practising by the evidence: the role of pathology. J Clin Pathol. 50 :447-448. Retrieved from https://doi.org/10.1136/jcp.50.6.447 DOI: https://doi.org/10.1136/jcp.50.6.447
Biomarkers Definitions Working Group (2001). Biomarkers and surrogate endpoints : preferred definitions and conceptual framework. Clin Pharmacol Ther. 69 :89-95. Retrieved from https://doi.org/10.1067/mcp.2001.113989 DOI: https://doi.org/10.1067/mcp.2001.113989
Bridget B. Kelly, (2011) editors : Institute of Medicine of the National. Promoting cardiovascular health in the developing world : a critical challenge to achieve global health. Washington, D.C. : National Academies Press; 220109780309147743. Retrieved from https://doi.org/10.1016/j.gheart.2011.08.002 DOI: https://doi.org/10.1016/j.gheart.2011.08.002
Choudhury MBK, Rahman MS, Hassan MM, Begum R, Hoque N, Akhtaruzzaman M : Chowdhury AN. (2011). Comparison of Serum Magnesium and Potassium in Acute Myocardial Infarction and Chronic Ischemic Heart Disease. J. Dhaka National Med. Coll. Hos., 17 :33-36. Retrieved from https://doi.org/10.3329/jdnmch.v17i1.12190 DOI: https://doi.org/10.3329/jdnmch.v17i1.12190
Cihat Sanli, Deniz Oguz, Rana Olgunturk, et al. (2012). Elevated homocysteine and asymmetric dimethyl arginine levels in pulmonary hypertension associated with congenital heart disease. Retrieved from https://doi.org/10.1007/s00246-012-0321-9 DOI: https://doi.org/10.1007/s00246-012-0321-9
Healthdata.org (2019), Sudan: National institute for health ,metrics and evaluation.
Inaba, Y, Chen, JA, Bergmann, SR (2012) (January 2012 : Carotid plaque, compared with carotid intima-media thickness, more accurately predicts coronary artery disease events: à meta-analysis.. Atherosclerosis 220. 1 :128-33. Retrieved from https://doi.org/10.1016/j.atherosclerosis.2011.06.044 DOI: https://doi.org/10.1016/j.atherosclerosis.2011.06.044
Jackson R, Chambles L, Higgins M, Kuulasmaa K, Wijnberg L, Williams D (1999) (WHO MONICA Project, and ARIC Study.) Sex difference in ischaemic heart disease mortality and risk factors in 46 communities: an ecologic analysis. Cardiovasc Risk Factors. 7 :43-54.
John Danesh, Peter Whincup, Mary Walker, Lucy Lennon, Andrew Thomson, Paul Appleby, Ann Rumley, Gordon D.O. (2001) Low Fibrin D-Dimer and Coronary Heart Disease. Retrieved from https://doi.org/10.1161/01.CIR.103.19.2323 DOI: https://doi.org/10.1161/01.CIR.103.19.2323
Jousilahti P, Vartiainen E, Tuomilehto J, Puska P (March 1999). "Sex, age, cardiovascular risk factors, and coronary heart disease: à prospective follow-up study of 14 786 middle-aged men and women in Finland". Circulation. 99 (9) : 1165-72. Klatsky AL (May 2009 : Alcohol and cardiovascular diseases. Expert Rev Cardiovasc Ther 7. 5 :499-506. Retrieved from https://doi.org/10.1161/01.CIR.99.9.1165
Korean J (2016). Intern Med., 31 :1009-1017. Retrieved from https://doi.org/10.3904/kjim.2016.078 DOI: https://doi.org/10.3904/kjim.2016.078
LaBaer J (2005) So, you want to look for biomarkers. J Proteome Res., 4 :1053-1059. Retrieved from https://doi.org/10.1021/pr0501259 DOI: https://doi.org/10.1021/pr0501259
Linden W, Stossel C, Maurice J (1996). BMJ (Clinical research ed.) 345 : e3953. PMC 3392078. PMID 227 (April 1996 : Psychosocial interventions for patients with coronary artery disease : à meta-analysis. Arch. Intern. Med. 156. 7 :745-52. Retrieved from https://doi.org/10.1001/archinte.1996.00440070065008 DOI: https://doi.org/10.1001/archinte.1996.00440070065008
Mohammad Madjid, and Omid Fatemi (2013) Components of the Complete Blood Count as Risk Predictors for Coronary. Heart DiseaseTex Heart Inst J., 40 :1729.
Moien AB Khan, Muhammad Jawad Hashim, Halla Mustafa, et al. (2020). Global Epidemiology of Ischemic Heart Disease: Results from the Global Burden of Disease Study. Cureus. 12 :9349. Retrieved from https://doi.org/10.7759/cureus.9349 DOI: https://doi.org/10.7759/cureus.9349
NPS Medicinewise (1 March 2011). "NPS : Prescribing Practice Review 53 : Managing lipids". Retrieved 1 August. 2011.
Norhammar A, Malmberg K, Diderhol E, et al. (2004). Diabetes mellitus: the major risk factor in unstable coronary artery disease even after consideration of the extent of coronary artery disease and benefits of revascularization. J. Am Coll Cardiol. 43 :585-591. Retrieved from https://doi.org/10.1016/j.jacc.2003.08.050 DOI: https://doi.org/10.1016/j.jacc.2003.08.050
Patel KV, Ferrucci L, Eeshler WB, Longo DL, Guralnik JM (2009). Red blood. 515-23. Retrieved from https://doi.org/10.1001/archinternmed.2009.11 DOI: https://doi.org/10.1001/archinternmed.2009.11
Puddu PE, Lanti M, Menotti A, et al. (2002) Red blood cell count in short -term prediction of cardiovascular disease incidence in the Gubbio population study. Acta cardiol, 57 :177-85. Retrieved from https://doi.org/10.2143/ac.57.3.2005387 DOI: https://doi.org/10.2143/AC.57.3.2005387
Robert Ostfeld, Michael Spinelli, Disha Mookherjee, et al. (2005). The association of BUN levels and coronary heart disease, albert Einstein college of medicine.
Sergio Bertazzo, Eileen Gentleman, Kristy L. Cloyd, et al. (2013) Nano-analytical electron microscopy reveals fundamental insights into human cardiovascular tissue calcification. Nature Materials. 12 :576-583. Retrieved from https://doi.org/10.1038/nmat3627 DOI: https://doi.org/10.1038/nmat3627
Threapleton, D. E., Greenwood, D. C., Evans, et al. (2013) Dietary fibre intake and risk of cardiovascular disease: systematic review and meta-analysis. BMJ 347. 19 :6879-6879. Cite uses deprecated parameters. Retrieved from https://doi.org/10.1136/bmj.f6879 DOI: https://doi.org/10.1136/bmj.f6879
Toshio Kobayashi, Yuji Miyoshi, Kazue Yamaoka And Eiji Yano (2001). Relationship between Hematological Parameters and Incidence of Ischemic Heart Diseases among Japanese White-Collar Male Workers. Occup Health, 43 :85-89. Retrieved from https://doi.org/10.1539/joh.43.85 DOI: https://doi.org/10.1539/joh.43.85
Volanakis JE (2001), Human C-reactive protein: expression, structure, and function. Mol Immunol ,38. 189 :197. Retrieved from https://doi.org/10.1016/S0161-5890(01)00042-6 DOI: https://doi.org/10.1016/S0161-5890(01)00042-6
Wang TJ, Gona P, Larson MG, et al. (2006), Multiple biomarkers for the prediction of first major cardiovascular events and death. N. Engl. J. Med. 355. 25 :2631-9. Retrieved from https://doi.org/10.1056/NEJMoa055373 DOI: https://doi.org/10.1056/NEJMoa055373
Yilmaz, N., Yegin A, Aykal G (2010), New Noninvasive Modalities in Coronary Angiography - Diagnostic Values of New Biomarkers for Cardiovascular Disease.2011. Retrieved from https://doi.org/10.5772/18213 DOI: https://doi.org/10.5772/18213
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