• Eman Saber Elhennawy Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt
  • Abeer Mesbah Abd-El Hamid Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt
  • Tharwat Saad Kandil Department of Gastroenterology, Faculty of Medicine, Mansoura University, Mansoura, Egypt
  • Mohammed Mohammed El-Sayed El-Arman Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt
  • Rasha Elzehery Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt



CD24,, Colorectal Cancer, Single Nucleotide Polymorphism, Carcinogenesis

Abstract [English]

Introduction: Early detection of colorectal cancer (CRC) is the key to reduce its related morbidity and mortality. Methods: One hundred CRC patients were included in this study, they were admitted at Mansoura Gastroenterology Center, Mansoura University and diagnosis was confirmed by pathology.100 apparently healthy individuals were served as the control group.CD24 (P170 C/T) and CD24 (P-534 A/C) single nucleotide polymorphisms (SNPs) were analyzed using polymerase chain reaction–restriction fragment length polymorphism (PCR/RFLP). Results: Regarding CD24 P170 C/T SNP, no statistically significant association was found between genotypes, alleles and risk of CRC. While, P-534 A/C; AC, CC, AC+CC genotypes and C allele showed significantly higher frequency in cases when compared to controls. CC and TC haplotypes were significantly associated with risk of CRC when compared to control group. Multivariate logistic regression analysis revealed that higher CEA and P-534 A/C (AC+CC) were considered as independent predictors of higher CRC stages. Conclusion: The current study observed an association between CD24 P-543 A/C SNP and the risk of developing CRC in Egyptian subjects.


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How to Cite

Elhennawy, E. S., Abd-El Hamid, A. M., Kandil, T. S., El-Arman, M. M. E.-S., & Elzehery, R. (2021). CD24 GENE POLYMORPHISMS IN EGYPTIAN PATIENTS WITH COLORECTAL CANCER. International Journal of Research -GRANTHAALAYAH, 9(10), 337–348.