DIFFERENTIAL EXPRESSION OF MICRORNA IN GENERALIZED ANXIETY DISORDER AND ITS ASSOCIATION WITH SOCIAL SUPPORT

Authors

  • Lingming Kong Prevention and Treatment Center for Psychological Diseases, No. 904 Hospital of Chinese PLA, Changzhou 213003, Jiangsu, China
  • Xiaoli Zhu Prevention and Treatment Center for Psychological Diseases, No. 904 Hospital of Chinese PLA, Changzhou 213003, Jiangsu, China
  • Wei Niu Department of Rehabilitation, No.904 Hospital of Chinese PLA, Changzhou, Jiangsu 213003, China
  • Liyi Zhang Prevention and Treatment Center for Psychological Diseases, No. 904 Hospital of Chinese PLA, Changzhou 213003, Jiangsu, China

DOI:

https://doi.org/10.29121/granthaalayah.v9.i9.2021.4265

Keywords:

GAD, MicroRNA, Social Support, Personality

Abstract

To explore the differential expression of microRNA (miRNA, miR-) and its correlation with social support and personality in Generalized Anxiety Disorder (GAD) patients. A total of 80 GAD patients and 80 control participants were selected from our serial study samples to be tested for microarray analysis, and real time quantitative Polymerase Chain Reaction (qRT-PCR) verification was carried out in both patient group and control group. Correlation between miRNA expression and social support were also carried out. According to microarray analysis, 6 miRNAs were differentially expressed between patient group and control group, with miR-4505, miR-4484, miR-4674, miR-501-3p and miR-663 up-regulated, and miR-1301 down-regulated; qPCR verification revealed that 5 miRNAs (miR-1301, miR-4484, miR-4674,  miR-501-3p, miR-663, miR-4505) were significantly up-regulated and the expression of miRNA-1301 down-regulated; the expression of miRNA-1301 was significantly related to social support in GAD patients. In conclusions, comprehensive factors, including miRNA regulation, social support may be involved into the aetiology of GAD.

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References

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Published

2021-10-09

How to Cite

Kong, L., Zhu, X., Niu, W., & Zhang, L. (2021). DIFFERENTIAL EXPRESSION OF MICRORNA IN GENERALIZED ANXIETY DISORDER AND ITS ASSOCIATION WITH SOCIAL SUPPORT. International Journal of Research -GRANTHAALAYAH, 9(9), 286–292. https://doi.org/10.29121/granthaalayah.v9.i9.2021.4265

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