GARDNER’S SYNDROME AS THE FIRST MANIFESTATION OF FAP IN PATIENT WITH METASTATIC RECTAL CANCER - AN EXTREMELY RARE OCCURRENCE

Authors

  • J Clarke Department of Otolaryngology, Head and Neck Surgery, San Fernando Teaching Hospital, Trinidad & Tobago
  • S Islam Department Of Surgery, San Fernando Teaching Hospital, SWRHA, Trinidad & Tobago
  • S Medford Department of Otolaryngology, Head and Neck Surgery, San Fernando Teaching Hospital, Trinidad & Tobago
  • S Juman
  • P Harnarayan Department of the Clinical Surgical Science, University of the West Indies, St. Augustine, Trinidad and Tobago https://orcid.org/0000-0001-8585-3288
  • V Naraynsingh Department of the Clinical Surgical Science, University of the West Indies, St. Augustine, Trinidad and Tobago https://orcid.org/0000-0001-5099-6203

DOI:

https://doi.org/10.29121/granthaalayah.v9.i8.2021.4188

Keywords:

Gardener’s Syndrome, FAP (Familial Adenomatous Polyposis), Extra-Colonic Manifestations

Abstract

Familial adenomatous polyposis [FAP] is a rare autosomal disorder. FAP presenting with Gardner syndrome is even rarer. Gardner syndrome as the first manifestation of FAP without any prior family history is even scarcer. We hereby report the case of 32 years healthy male referred to our otolaryngology clinic with a neck mass and ultimately diagnosed with a case of Gardner syndrome with FAP and advanced rectal Cancer. The patient had a successful gastrointestinal surgery with follow up chemotherapy. Subsequently the patient was followed up at the gastroenterology, oncology and surgical clinic. Literature searched was done and the extra colonic manifestations of the diseases are highlighted in our discussion.

Downloads

Download data is not yet available.

References

Arora P SP (2014). Gardener Syndrome: A Rare Case Report. Dentistry [Internet]; 05(04). Retrieved from https://doi.org/10.4172/2161-1122.1000233 DOI: https://doi.org/10.4172/2161-1122.1000233

Cankaya AB, Erdem MA, Isler SC, Cifter M, Olgac V, Kasapoglu C, et al. Oral and Maxillofacial (2012) Considerations in Gardner's Syndrome. Int J Med Sci; 9(2):137-41. Retrieved from https://doi.org/10.7150/ijms.3989 DOI: https://doi.org/10.7150/ijms.3989

Charifa A, Jamil RT, Zhang X. (2021) Gardner Syndrome. In: StatPearls [Internet]. Treasure Island (FL): Stat Pearls Publishing. Retrieved from http://www.ncbi.nlm.nih.gov/books/NBK482342/

Colella DM, Patel N, Israr F, Sobrado J. (2016) A Rare Case Report of Gardner Syndrome: A Familial Adenomatous Polyposis Variant: 2585. Off J Am Coll Gastroenterol ACG. Oct;111:S1303. Retrieved from https://doi.org/10.14309/00000434-201610001-02585 DOI: https://doi.org/10.14309/00000434-201610001-02585

Dermatologic Manifestations of Gardner Syndrome (2021): Background, Pathophysiology, Etiology. Apr 5. Retrieved from https://emedicine.medscape.com/article/1093486-overview

Diwan AH, Graves ED, King JAC, Horenstein MG. (2000) Nuchal-Type Fibroma in Two Related Patients With Gardner's Syndrome. Am J Surg Pathol. Nov;24(11):1563-7. Retrieved from https://doi.org/10.1097/00000478-200011000-00015 DOI: https://doi.org/10.1097/00000478-200011000-00015

Fotiadis C, Tsekouras D, Antonakis P, Sfiniadakis J, Genetzakis M, Zografos G. (2005) Gardner's syndrome: A case report and review of the literature. World J Gastroenterol. Sep 14;11(34):5408-11. Retrieved from https://doi.org/10.3748/wjg.v11.i34.5408 DOI: https://doi.org/10.3748/wjg.v11.i34.5408

Seehra J, Patel S, Bryant C. (2016) Gardner's Syndrome Revisited: A Clinical Case and Overview of the Literature. J Orthod. Mar; 43(1):59-64. Retrieved from https://doi.org/10.1179/1465313315Y.0000000008 DOI: https://doi.org/10.1179/1465313315Y.0000000008

Singla. (2015) Gardner's syndrome: A case report and review of literature [Internet].; vol- 27; issue 4; page 625-628, Retrieved from https://doi.org/10.4103/0972-1363.188779 DOI: https://doi.org/10.4103/0972-1363.188779

Verma P, Surya V, Kadam S, Umarji HR. (2016) Classical presentation of Gardner's syndrome in an Indian patient: A case report. Contemp Clin Dent;7(2):277-80. Retrieved from https://doi.org/10.4103/0976-237X.183063 DOI: https://doi.org/10.4103/0976-237X.183063

Yu D, Cw BN, Zhu H, Liu J, Lin Y. (2018) Bone and dental abnormalities as first signs of familial Gardner's syndrome in a Chinese family: a literature review and a case report. médecine/sciences. Oct 1;34:20-5. Retrieved from https://doi.org/10.1051/medsci/201834f104 DOI: https://doi.org/10.1051/medsci/201834f104

Downloads

Published

2021-09-10

How to Cite

Clarke, J., Islam, S., Medford, S., Juman, S., Harnarayan, P., & Naraynsingh, V. (2021). GARDNER’S SYNDROME AS THE FIRST MANIFESTATION OF FAP IN PATIENT WITH METASTATIC RECTAL CANCER - AN EXTREMELY RARE OCCURRENCE. International Journal of Research -GRANTHAALAYAH, 9(8), 349–354. https://doi.org/10.29121/granthaalayah.v9.i8.2021.4188