• Lemii, B. Cletus Department of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences, College of Medical Sciences, Rivers State University, Port Harcourt, Nigeria
  • Onwunari, A. Georgewill Department Of Pharmacology, Faculty Of Basic Clinical Sciences, College Of Health Sciences University Of Port Harcourt Port Harcourt, Nigeria




Toxicity, Different Brands Of Piroxicam


BACKGROUD: , a non-steroidal anti-inflammatory drug (NSAID), has been identified to be one of such drugs with great potentials for abuse, addiction and death as well as complaints on the significant dissimilarities and variations of possible organ toxicities across different brands. This study aimed at evaluating toxicity profiles of different brands of in male rats. Healthy thirty (30) male rats, weighing between 180 and 230grams were procured from the animal house of the Pharmacology department, Faculty of Basic Clinical Sciences in University of Port Harcourt, Nigeria. METHODS: The animals were divided into six (6) groups of five (5) animals each. Group1-control group while group2 to 6 were treatment groups. Thereafter, the clinical dose (0.285mg/kg) of brands (A Brand, B Brand, C Brand, D Brand and E Brand) were administered on treatment groups. The analysis was done at the end of the experiment. RESULT: Reveals that, four out of the fives brands demonstrated significant (p<0.05) toxicities on liver and kidney. Two of the brands has predilection for liver toxicity while another two exhibited kidney toxicities. The heart organ was spared from toxic effects of all the five brand understudied. CONCLUSION: The degree of organ toxicities with different brands of varies, however, certain brands tend to have toxicity predilection for either the liver or kidney.


Download data is not yet available.


Awodele, O., Fadipe, A., Adekoya, M. & Adeyemi, O. (2015). Prescribing Pattern of Non-Steroidal Ant­‐inflammatory Drugs at the Outpatient Pharmacy Department of Lagos University Teaching Hospital, Nigeria. Ghana Medical Journal 49(1), 25. Retrieved from https://dx.doi.org/10.4314/gmj.v49i1.5 10.4314/gmj.v49i1.5 DOI: https://doi.org/10.4314/gmj.v49i1.5

Ebaid, H., Dkhil, M. A., Danfour, M. A., Tohamy, A. & Gabry, M. S. (2007). Piroxicam-Induced Hepatic And Renal Histopathological Changes In Mice. Libyan Journal Of Medicine 2(2), 82–89. DOI: https://doi.org/10.3402/ljm.v2i2.4700

Ingrasciotta, Y., Sultana, J., Giorgianni, F., Fontana, A., Santangelo, A., Tari, D. U., Santoro, D., Arcoraci, V., Perrotta, M., Ibanez, L. & Trifirò, G. (2015). Association of Individual Non-Steroidal Anti-Inflammatory Drugs and Chronic Kidney Disease: A Population-Based Case Control Study. PLOS ONE 10(4), e0122899. Retrieved from https://dx.doi.org/10.1371/journal.pone.0122899 10.1371/journal.pone.0122899 DOI: https://doi.org/10.1371/journal.pone.0122899

Modi, C. M., Mody, S. K., Patel, H. B., Dudhatra, G. B., Kumar, A. & Avale, M. (2012). Toxicopathological Overview Of Analgesic And Anti-Inflammatory Drugs In Animals. Journal Of Applied Pharmaceutical Science 2(1), 149–157.

(2017). NRC [National Research Council] Guidelines Of The National Institute Of Health (NIH) For Care And Us Of Laboratory/Research Animals [Accessed Online From: . Retrieved from Https://Grants.Nih.Gov/Grants/Olaw/Guide-For-The-Care-And-Use-Of-Laboratory-Animals.Pdf

Omar, R. S. (2018). Piroxicam-Induced Hepatotoxicity. Biomed J Sci &Tech Res 2(3), 2601–2006. DOI: https://doi.org/10.26717/BJSTR.2018.02.000752

Sahu, C. R. (2016). Mechanisms Involved in Toxicity of Liver Caused by Piroxicam in Mice and Protective Effects of Leaf Extract of Hibiscus Rosa-Sinensis L. Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders 9, CMAMD.S29463. Retrieved from https://dx.doi.org/10.4137/cmamd.s29463 10.4137/cmamd.s29463 DOI: https://doi.org/10.4137/CMAMD.S29463

Sarpatwari, A., DiBello, J., Zakarian, M., Najafzadeh, M. & Kesselheim, A. S. (2019). Competition and price among brand-name drugs in the same class: A systematic review of the evidence. PLOS Medicine 16(7), e1002872. Retrieved from https://dx.doi.org/10.1371/journal.pmed.1002872 10.1371/journal.pmed.1002872 DOI: https://doi.org/10.1371/journal.pmed.1002872

Wale, D. (2015). Five Drugs Commonly Abused By Nigerians And Their Adverse Effects. . Retrieved from Www.Nigerianbulletin,Com/Threads 13/4/2019

Wang, S. Y. & Jiao, H. (2000). Scavenging Capacity of Berry Crops on Superoxide Radicals, Hydrogen Peroxide, Hydroxyl Radicals, and Singlet Oxygen. Journal of Agricultural and Food Chemistry 48(11), 5677–5684. Retrieved from https://dx.doi.org/10.1021/jf000766i 10.1021/jf000766i DOI: https://doi.org/10.1021/jf000766i



How to Cite

Lemii, B. C., & Onwunari, A. G. (2021). EVALUATION OF TOXICITY PROFILES OF DIFFERENT BRANDS OF PIROXICAM IN WISTAR RATS. International Journal of Research -GRANTHAALAYAH, 9(6), 36–44. https://doi.org/10.29121/granthaalayah.v9.i6.2021.3975