TY - JOUR AU - ALADAĞ, Tuğçe AU - FIRAT, Fatma PY - 2022/01/31 Y2 - 2024/03/28 TI - COMPARATIVE EFFECTS OF BORIC ACID AND RESVERATROL ON MCF-7 BREAST CANCER CELLS METASTATIC BEHAVIOUR JF - International Journal of Research -GRANTHAALAYAH JA - Int. J. Res. Granthaalayah VL - 10 IS - 1 SE - Articles DO - 10.29121/granthaalayah.v10.i1.2022.4460 UR - https://www.granthaalayahpublication.org/journals/granthaalayah/article/view/4460 SP - 34-46 AB - <p><u>Motivation/Background:</u>The metastasis of tumor cells consists of steps such as epithelial-mesenchymal transition, transendothelial migration and the formation of metastatic colonization. E-Cadherin and vimentin are main proteins associated with EMT, whereas MMP-9 is associated with migration.</p><p><u>Method:</u>We aimed to investigate effects boric acid and resveratrol comparatively on metaatatic behaviors on MCF-7. 30μM boric acid and 50μM resveratrol were administered to&nbsp; BA, BA+RES, and RES groups 48hours. Cells stained immunocytochemically by Anti-E-Cadherin, Anti-Vimentin, and Anti-MMP-9 antibodies and H-Score analysis carried out and migration&nbsp; analyzed by woundhealing, morphologically.</p><p><u>Results and</u><u>Conclusions:</u>It’s been observed that boric acid doesn’t affect the EMT capability of the MCF-7 cells in terms of E-Cadherin and vimentin&nbsp; expression; whereas, it’s affect&nbsp; migration both by decreasing the MMP-9 expression and also by inhibiting&nbsp; migration.</p> ER -