IN VITRO ANTI – INFLAMMATORY ACTIVITY OF THE FLOWERS OF NERIUM OLEANDER (WHITE)

Authors

  • Dr.S.Jasmine Mary Lecturer in Chemistry, Government College for Women (Autonomous), Kumbakonam, Tamilnadu-612001, India
  • B.Chithra Research Scholar, AVMM Sri Pushpam College, Poondi, India
  • Dr.S.Sivajiganesan Assistant Professor, AVMM Sri Pushpam College, Poondi, India

DOI:

https://doi.org/10.29121/granthaalayah.v5.i6.2017.2005

Keywords:

Inflammation, Nerium Oleander, Nsaids, Egg Albumin, Diclofenac Sodium

Abstract [English]

Inflammation is a part of the complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells or irritants. It is characterized by redness, swollen joints, joint pain, its stiffness and loss of joint function. Inflammation is currently treated by NSAIDs. Unfortunately these drugs cause increased risk of blood clot resulting in heart attacks and strokes. Therefore, the developments of potent anti-inflammatory drugs from the natural products are now under considerations. Natural products are rich source for discovery of new drugs because of their chemical diversity. A natural product from medicinal plants plays a major role to cure many diseases associated with inflammation. The conventional drug available in the market to treat inflammation produces various side-effects. In this present study anti-inflammatory potential of Nerium Oleander was investigated. Based on the resulted the ethonolic extract of the flowers showed the highest anti inflammatory activity. The increments in absorbance of test samples with respect to control indicated stabilization of protein i.e. inhibition of heat-induced protein (albumin) denaturation by Nerium oleander and reference drug diclofenac sodium.

Downloads

Download data is not yet available.

References

Schimmer BP, Parker KL. Adrenocorticotropic hormone; adrenocortical steroids and their synthetic analogs; Inhibitors of the synthesis and actions of adrenocortical hormones. In: Hardman JG, Limbird LE, Gilman AG, editors. Goodman and Gilman’s The pharmacological basis of therapeutics. 10th Edition. USA: McGraw; 2001. pp 1649–1677.

Ramos CL Pauk S Brittigan BE Cohen MS and Rosen GM, (1992) Spin trapping evidence for myelo-peroxidase-dependent, hydroxyl radica formation by human neutrophills and monocutes. The Journal of Biological Chemistry. 267, 8307-8312.

Trenam CW Blake DR and Morris CJ (1992) Skin inflammation reactaive oxygen species and the role of iron. The Journal of Investigative Dermotology. 99, 675-682. DOI: https://doi.org/10.1111/1523-1747.ep12613740

Sangita Chandra, Priyanka Chatterjee, Protapaditya Dey and Sanjib Bhattacharya. (2012) Evaluation of in vitro anti-inflammatory activity of coffee against the denaturation of protein.Asian Pacific Journal of Tropical Biomedicine, 178-180. DOI: https://doi.org/10.1016/S2221-1691(12)60154-3

Ahmadiani A, Fereidoni M, Semnanian S, Kamalinejad M and Saremi S. (1998) Antinociceptive and anti-inflammatory effects of Sambucus ebulus rhizome extract in rats. Journal of Ethnopharmacology, 61(2): 229-232. DOI: https://doi.org/10.1016/S0378-8741(98)00043-9

Kumarappan CT, Chandra R and Mandal SC. (2006) Anti-inflammatory activity of Ichnocarpus frutescens. Pharmacologyonline, 3 (2): 201-206.

Arivazhagan S, Balasenthi S and Nagini S. (2000) Antioxidant and anti-inflammatory activities of Mallotus oppostifolium. Journal of Phytotherapy Research, 14 (4) 291-293.

Grant NH, Alburn HE, Kryzanauskas C.(1970) Stabilization of serum albumin by anti-inflammatory drugs. Biochem Pharmacol.,19:715-722. DOI: https://doi.org/10.1016/0006-2952(70)90234-0

Jagtap VA, Agasimundim YS, Jayachandran E and Sathe BS. (2011) In vitro anti-inflammatory activity of 2-amino-3-(substituted benzylidine carbohydrazide)-4,5,6,7- tetrahydro benzo-thiophene. J PharmRes, 4: 378-379.

Khanna D, Gautam Sethi, Kwang Seok Ahn,Manoj K Pandey, Ajaikumar B Kunnumakkara, Bokyung Sung, Amita Aggarwa and Bharat B . (2007) Natural products as a gold mine for arthritis treatment. Current Opinion in Pharmacology .7:344–351. DOI: https://doi.org/10.1016/j.coph.2007.03.002

Downloads

Published

2017-06-30

How to Cite

Mary, S., Chithra, B., & Sivajiganesan, S. (2017). IN VITRO ANTI – INFLAMMATORY ACTIVITY OF THE FLOWERS OF NERIUM OLEANDER (WHITE). International Journal of Research -GRANTHAALAYAH, 5(6), 123–128. https://doi.org/10.29121/granthaalayah.v5.i6.2017.2005