CORRELATION OF AGE WITH COVID-19 IGG ANTIBODIES TITRE IN THE ADULT POPULATION OF MALEGAON: A PROSPECTIVE OBSERVATIONAL STUDY
DOI:
https://doi.org/10.29121/granthaalayah.v11.i9.2023.5015Keywords:
IgG Antibody, Covid-19, MalegaonAbstract [English]
Introduction: The year 2019 was affected by Pneumonia caused by SARS Cov 2 virus. This major health challenge whole world is facing and IgG antibodies titre has been widely used to assist the diagnostic and prognostic value. Important aspect of aging is decline in immune function. As per the aging process there are changes at humoral and cellular immune responses leading to impaired immune response which in turn leads to risk of infectivity and decreased vaccine responses. The current study's objectives were to assess the SARS-COV-2 antibody titre in the adult urban Malegaon population and to look for a relationship between age and antibody titre.
Methods: Individuals who were residing in densely populated Malegaon village where formerly COVID- 19 was declared as hot spot during first wave were included with total sample size of 2454 and their blood samples were collected to get IgG antibodies from 12 January 2022 to 18 January 2022.
Results: In this study we found that when the age advances the % of antibody level doesn’t change significantly. In 2454 samples there observed non-significant difference in antibody % and age group (p>0.05)
Conclusion: These findings suggest extensive studies are required to bring uniform guideline for developing the vaccine strategy as age and antibodies level remained the same.
Downloads
References
Bajaj, V., Gadi, N., Spihlman, A. P., Wu, S. C., Choi, C. H., & Moulton, V. R. (2020). Aging, Immunity, and COVID-19 : How Age Influences the Host Immune Response to Coronavirus Infections?, 11. https://doi.org/10.3389/fphys.2020.571416. DOI: https://doi.org/10.3389/fphys.2020.571416
Crooke, S. N., Ovsyannikova, I. G., Poland, G. A., & Kennedy, R. B. (2019). Immunosenescence : A Systems-Level Overview of Immune Cell Biology and Strategies for Improving Vaccine Responses. Experimental Gerontology, 124. https://doi.org/10.1016/j.exger.2019.110632. DOI: https://doi.org/10.1016/j.exger.2019.110632
Du, X., Yu, X., Li, Q., Li, X., Qin, T., Luo, Q., Wang, M., Jiang, M., Bai, L., Wang, X., Pan, Y. (2020). Duration for Carrying SARS-CoV-2. In COVID-19 Patients. Journal Infectology, 81(1), e78-e79. https://doi.org/10.1016/j.jinf.2020.03.053. DOI: https://doi.org/10.1016/j.jinf.2020.03.053
Frasca, D., Diaz, A., Romero, M., Landin, A. M., & Blomberg, B. B. (2011). Age Effects on B Cells and Humoral Immunity in Humans. Ageing Research Reviews, 10(3), 330-335. https://doi.org/10.1016/j.arr.2010.08.004. DOI: https://doi.org/10.1016/j.arr.2010.08.004
Hou, H., Wang, T., Zhang, B., Luo, Y., Mao, L., Wang, F., Wu, S., & Sun, Z. (2020). Detection of and IgG Antibodies in Patients with Coronavirus Disease 2019. Clinical and Translational Immunology, 9(5), https://doi.org/10.1002/cti2.1136. DOI: https://doi.org/10.1002/cti2.1136
Li, Z., Yi, Y., Luo, X., Xiong, N., Liu, Y., Li, S., Sun, R., Wang, Y., Hu, B., Chen, W., Zhang, Y., Wang, J., Huang, B., Lin, Y., Yang, J., Cai, W., Wang, X., Cheng, J., Chen, Z., Ye, F. (2020). Development and Clinical Application of a Rapid -IgG Combined Antibody Test for SARS-CoV-2 Infection Diagnosis. Journal of Medical Virology, 92(9), 1518-1524. https://doi.org/10.1002/jmv.25727. DOI: https://doi.org/10.1002/jmv.25727
Liu, C., Yu, X., Gao, C., Zhang, L., Zhai, H., Hu, Y., Liu, E., Wang, Q., Gao, Y., Wei, D., Zhang, D., Han, Y., & Zhang, X. (2021). Characterization of Antibody Responses to SARS-CoV-2 in Adult Malegaon Population COVID-19 Patients. Journal of Medical Virology, 93(4), 2227-2233. https://doi.org/10.1002/jmv.26646. DOI: https://doi.org/10.1002/jmv.26646
Long, Q. X., Liu, B. Z., Deng, H. J., Wu, G. C., Deng, K., Chen, Y. K., Liao, P., Qiu, J. F., Lin, Y., Cai, X. F., Wang, D. Q., Hu, Y., Ren, J. H., Tang, N., Xu, Y. Y., Yu, L. H., Mo, Z., Gong, F., Zhang, X. L., Huang, A. L. (2020). Antibody Responses to SARS-CoV-2 in Patients with COVID-19. Nature Medicine, 26(6), 845-848. https://doi.org/10.1038/s41591-020-0897-1. DOI: https://doi.org/10.1038/s41591-020-0897-1
Rawandale, N. A., Pagar, V. S., Suryawanshi, M. M., Chavan, S. S., Jain, J. M., Saple, P. S. P., & Kanitkar, M. R. (2022). An Epidemiological Study to Determine Demographic Factors Influencing Covid-19 IgG Antibody Production Among the Adult Population of Urban Area in Malegaon, Maharashtra - A Cross Sectional Study. Asian Journal of Medical Sciences, 13(10), 3-11. https://doi.org/10.3126/ajms.v13i10.46722. DOI: https://doi.org/10.3126/ajms.v13i10.46722
Ueno, A., Kawasuji, H., Miyajima, Y., Fukui, Y., Sakamaki, I., Saito, M., Yamashiro, S., Morinaga, Y., Oishi, K., & Yamamoto, Y. (2021). Prolonged Viral Clearance of Severe Acute Respiratory Syndrome Coronavirus 2 in the Older Aged Population. Journal of Infection and Chemotherapy, 27(7), 1119-1121. https://doi.org/10.1016/j.jiac.2021.03.007. DOI: https://doi.org/10.1016/j.jiac.2021.03.007
Zainol Rashid, Z., Othman, S. N., Abdul Samat, M. N., Ali, U. K., & Wong, K. K. (2020). Diagnostic Performance of COVID-19 Serology Assays. The Malaysian Journal of Pathology, 42(1), 13–21.
Zeng, F., Dai, C., Cai, P., Wang, J., Xu, L., Li, J., Hu, G., Wang, Z., Zheng, F., & Wang, L. (2020). A Comparison Study of SARS-CoV-2 IgG Antibody Between Male and Female COVID-19 Patients : A Possible Reason Underlying Different Outcome Between Sex. Journal of Medical Virology, 92(10), 2050-2054. https://doi.org/10.1002/jmv.25989. DOI: https://doi.org/10.1002/jmv.25989
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Kamlesh Popatlal Bagmar, Dr. Farooq F. Motiwala, Dr. Vishal N. Nimbhore, Dr. Swanand N. Shukla, Dr. Subhash M. Yadav, Dr. Madhuri Kanitkar
This work is licensed under a Creative Commons Attribution 4.0 International License.
With the licence CC-BY, authors retain the copyright, allowing anyone to download, reuse, re-print, modify, distribute, and/or copy their contribution. The work must be properly attributed to its author.
It is not necessary to ask for further permission from the author or journal board.
This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge.
