IMPROVEMENT OF THE LIFE QUALITY FOR LARYNGOPHARYNGEAL REFLUX PATIENTS AFTER RECEIVING PROTON PUMP INHIBITOR (PPI) THERAPY AT THE ENT-KL POLYCLINIC OF UKI HOSPITAL JANUARY 2021 - FEBRUARY 2021
DOI:
https://doi.org/10.29121/granthaalayah.v9.i4.2021.3866Keywords:
Quality Of Life (QOL), Laryngopharyngeal Reflux (LPR), Reflux Symptom Index, Pump Inhibitor (PPI)Abstract [English]
(LPR) is a condition in which gastric content to the and reaches larynx and pharynx so that mucous membranes of the larynx, pharynx, and other respiratory organs are inflamed. The symptoms of LPR can affect daily activities, resulting in a decrease in the quality of life (QOL) of the patients. Proton Pump Inhibitor (PPI) is the main therapy for patients with LPR. PPI can improve the symptoms experienced by patients with LPR. The objective of this research is to determine the QOL of patients with LPR after receiving PPI. This research's method is quasi-experimental studies using and post-test design from January 2021 to February 2021, in 18 patients were assessed for QOL scores using RSI. Each patient was administered 30 mg twice daily before meals for 14 days. Two times of observations are done, before therapy and 14 days after therapy. Data analysis using paired sample T-test. The result is that there is a significant improvement in QOL of patients with LPR on RSI scores after 14 days of administration of 30 mg. (p<0,05). It is concluded that PPI significantly improved the QOL of patients with LPR.
Downloads
References
Ahmed Osman, H. , Hassan Abd Elrhman, N. & Abdel Shafy, M. (2019). The Efficacy of PPI in the Treatment of Laryngopharyngeal Reflux. Journal of Gastroenterology and Hepatology Research 8(1), 2800–2806. Retrieved from https://dx.doi.org/10.17554/j.issn.2224-3992.2019.07.803 10.17554/j.issn.2224-3992.2019.07.803 DOI: https://doi.org/10.17554/j.issn.2224-3992.2019.07.803
Albahout, K. S. & Lopez, R. A. (2020). Anatomy, Head and Neck, Pharynx. StatPearls. Anatomy, Head and Neck, Pharynx. StatPearls .
Alharethy, S., Baqays, A., Mesallam, T. A., Syouri, F., Wedami, M. A., Aldrees, T. & Alqabbani, A. (2018). Pengaruh suplementasi zinc terhadap perbaikan klinis penderita laryngopharyngeal reflux disease. Correlation between allergic rhinitis and laryngopharyngeal reflux . DOI: https://doi.org/10.1155/2018/2951928
Bajwa, S. A., Toro, F. & Kasi, A. (2020). Physiology. Physiology, Esophagus. StatPearls .
Campagnolo, A. & Benninger, M. S. (2019). Allergic laryngitis: chronic laryngitis and allergic sensitization. Brazilian Journal of Otorhinolaryngology 85(3), 263–266. Retrieved from https://dx.doi.org/10.1016/j.bjorl.2019.02.001 10.1016/j.bjorl.2019.02.001 DOI: https://doi.org/10.1016/j.bjorl.2019.02.001
Clarrett, D. M. & Hachem, C. (2018). Evaluation of the reflux symptom index and the endolaryngeal findings scale after treatment in individuals with laryngopharyngeal reflux. Gastroesophageal reflux disease (GERD). Missouri medicine 115, 214.
Drake, R., Drake, R. L., Vogl, W. & Mitchell, A. W. (2012). Gray's basic anatomy. Gray's basic anatomy .
Drake, R. L., Vogl, A. W. & Mitchell, A. W. M. (2015). Gray's anatomy for students. In Gray's anatomy for students ( Philadelphia. PA: Churchill Livingstone Elsevier , Ed. ).
Farmakologi, D. (2007). Farmakologi dan terapi. Terapeutik Fakultas Kedokteran Universitas Indonesia. Farmakologi dan terapi 5, 585–594.
Farmakologi, D. (2016). Farmakologi dan terapi. Terapeutik Fakultas Kedokteran Universitas Indonesia 485–486.
Febriyanti, R. (2014). Perbedaan Kualitas Hidup Pada Penderita Refluks Laringofaring Sebelum dan. Tesis) 1–106.
Fraser-Kirk, K. (2017). Laryngopharyngeal reflux: A confounding cause of aerodigestive dysfunction. Australian family physician 46(1/2), 34–39.
Glicksman, J. T., Mick, P. T., Fung, K. & Carroll, T. L. (2014). Prokinetic agents and laryngopharyngeal reflux disease: Prokinetic agents and laryngopharyngeal reflux disease: A systematic review. The Laryngoscope 124(10), 2375–2379. Retrieved from https://dx.doi.org/10.1002/lary.24738 10.1002/lary.24738 DOI: https://doi.org/10.1002/lary.24738
Gong, E. J., Choi, K. D., Jung, H. K., Youn, Y. H., Min, B. H., Song, K. H. & Huh, K. C. (2017). Quality of life, patient satisfaction, and disease burden in patients with gastroesophageal reflux disease with or without laryngopharyngeal reflux symptoms. Journal of gastroenterology and hepatology 32(7), 1336–1340. DOI: https://doi.org/10.1111/jgh.13716
Hasroni, A. & R. S. (2019). Korelasi Antara Karakteristik Refluks Berdasarkan Pemeriksaan. Korelasi Antara Karakteristik Refluks Berdasarkan Pemeriksaan Ph 24 Jammultichannel Intraluminal Impedance Dengan Kualitas Hidup Penderita Refluks Laringofaring Refrakter (Doctoral dissertation .
Joo, Y.-H., Song, Y.-S. & Pae, C.-U. (2017). Relationship between Depression and Laryngopharyngeal Reflux. Psychiatry Investigation 14(2), 226. Retrieved from https://dx.doi.org/10.4306/pi.2017.14.2.226 10.4306/pi.2017.14.2.226 DOI: https://doi.org/10.4306/pi.2017.14.2.226
Kung, Y. M., Tsai, P. Y., Chang, Y. H., Wang, Y. K., Hsieh, M. S., Hung, C. H. & Kuo, C. H. (2019). Allergic rhinitis is a risk factor of gastro-esophageal reflux disease regardless of the presence of asthma. Scientific reports 9(1), 1–8. DOI: https://doi.org/10.1038/s41598-019-51661-4
Kuo, C. L. (2019). Archives of Otorhinolaryngology-Head & Neck Surgery (AOHNS) Laryngopharyngeal reflux: An update. Archives of Otorhinolaryngology-Head & Neck Surgery (AOHNS) . DOI: https://doi.org/10.24983/scitemed.aohns.2019.00094
Lechien, J.R., Finck, C., Khalife, M., Huet, K., Delvaux, V., Picalugga, M., Harmegnies, B. & Saussez, S. (2018). Change of signs, symptoms and voice quality evaluations throughout a 3- to 6-month empirical treatment for laryngopharyngeal reflux disease. Clinical Otolaryngology 43(5), 1273–1282. Retrieved from https://dx.doi.org/10.1111/coa.13140 10.1111/coa.13140 DOI: https://doi.org/10.1111/coa.13140
Lechien, J. R., Akst, L. M., Hamdan, A. L., Schindler, A., Karkos, P. D., Barillari, M. R., Calvo-Henriquez, C., Crevier-Buchman, L., Finck, C., Eun, Y.-G., Saussez, S. & Vaezi, M. F. (2019). Evaluation and Management of Laryngopharyngeal Reflux Disease: State of the Art Review. Otolaryngology–Head and Neck Surgery 160(5), 762–782. Retrieved from https://dx.doi.org/10.1177/0194599819827488 10.1177/0194599819827488 DOI: https://doi.org/10.1177/0194599819827488
Lechien, J. R., Dapri, G., Dequanter, D., Rodriguez Ruiz, A., Marechal, M.-T., De Marrez, L. G., Saussez, S. & Fisichella, P. M. (2019). Surgical Treatment for Laryngopharyngeal Reflux Disease. JAMA Otolaryngology–Head & Neck Surgery 145(7), 655. Retrieved from https://dx.doi.org/10.1001/jamaoto.2019.0315 10.1001/jamaoto.2019.0315 DOI: https://doi.org/10.1001/jamaoto.2019.0315
Lechien, J. R., Saussez, S., Harmegnies, B., Finck, C. & Burns, J. A. (2017). Laryngopharyngeal Reflux and Voice Disorders: A Multifactorial Model of Etiology and Pathophysiology. Journal of Voice 31(6), 733–752. Retrieved from https://dx.doi.org/10.1016/j.jvoice.2017.03.015 10.1016/j.jvoice.2017.03.015 DOI: https://doi.org/10.1016/j.jvoice.2017.03.015
Lee, J. S., Lee, Y. C., Kim, S. W., Kwon, K. H. & Eun, Y. G. (2014). Changes in the quality of life of patients with laryngopharyngeal reflux after treatment. Journal of Voice 28(4), 487–491. DOI: https://doi.org/10.1016/j.jvoice.2013.12.015
Mallikarjunappa, A. M. & Deshpande, G. A. (2020). Comparison of Reflux Symptom Index (RSI) with Reflux Finding Score (RFS) and Its Effectiveness in Diagnosis of Laryngopharyngeal Reflux Disease (LPRD) Indian Journal of Otolaryngology and Head & Neck Surgery 1–5. Retrieved from https://dx.doi.org/10.1007/s12070-020-01814-z 10.1007/s12070-020-01814-z DOI: https://doi.org/10.1007/s12070-020-01814-z
Massawe, W. A., Nkya, A., Abraham, Z. S., Babu, K. M., Moshi, N., Kahinga, A. A., Ntunaguzi, D. & Massawe, E. R. (2021). Laryngopharyngeal reflux disease, prevalence and clinical characteristics in ENT department of a tertiary hospital Tanzania. World Journal of Otorhinolaryngology - Head and Neck Surgery 7(1), 28–33. Retrieved from https://dx.doi.org/10.1016/j.wjorl.2020.04.009 10.1016/j.wjorl.2020.04.009 DOI: https://doi.org/10.1016/j.wjorl.2020.04.009
(1997). Measuring quality of life. Geneva: World Health Organization. World Health Organization .
Mishra, P., Agrawal, D. & Artham, P. (2020). Screening Test for LPRD: History Versus Video Laryngoscopy. Indian Journal of Otolaryngology and Head & Neck Surgery 72(4), 422–427. Retrieved from https://dx.doi.org/10.1007/s12070-020-01828-7 10.1007/s12070-020-01828-7 DOI: https://doi.org/10.1007/s12070-020-01828-7
Mishra, P., Agrawal, D., Chauhan, K. & Kaushik, M. (2020). Prevalence of Laryngopharyngeal Reflux Disease in Indian Population. Indian Journal of Otolaryngology and Head & Neck Surgery 1–5. Retrieved from https://dx.doi.org/10.1007/s12070-020-01882-1 10.1007/s12070-020-01882-1 DOI: https://doi.org/10.1007/s12070-020-01882-1
Nanda, M. S. (2016). Role of adjuvant lifestyle modifications in patients with laryngopharyngeal reflux disease in hilly areas. Int J Sci Study 3(10), 114–122.
(2019). National Cancer Institute. Nasopharyngeal Cancer Treatment (Adult). Retrieved from https://www.cancer.gov/types/head-and-neck/patient/adult/nasopharyngeal-treatment-pdq
Newberry, C. & Lynch, K. (2019). The role of diet in the development and management of gastroesophageal reflux disease: why we feel the burn. Journal of Thoracic Disease 11(S12), S1594–S1601. Retrieved from https://dx.doi.org/10.21037/jtd.2019.06.42 10.21037/jtd.2019.06.42 DOI: https://doi.org/10.21037/jtd.2019.06.42
P., M., D., A. & P., A., Indian Journal of Otolaryngology and Head & Neck Surgery, (2021). Screening test for LPRD: history versus video laryngoscopy. 1–6. Retrieved from http://pionas.pom.go.id/ioni/bab-1-sistem-saluran-cerna-0/13-antitukak/134-penghambat-pompa-proton
Pramana, C., Muyassaroh, M. & Antono, D. (2015). Pengaruh suplementasi zinc terhadap perbaikan klinis penderita laryngopharyngeal reflux disease. Oto Rhino Laryngologica Indonesiana 44, 131. Retrieved from https://dx.doi.org/10.32637/orli.v44i2.94 10.32637/orli.v44i2.94 DOI: https://doi.org/10.32637/orli.v44i2.94
Priston, J., Thoen, R., Medeiros, T., Assunção, A. & Campagnolo, A. (2013). Laryngopharyngeal Reflux: Diagnosis, Treatment, and Latest Research. International Archives of Otorhinolaryngology 18, 184–191. Retrieved from https://dx.doi.org/10.1055/s-0033-1352504 10.1055/s-0033-1352504 DOI: https://doi.org/10.1055/s-0033-1352504
Putri, S. E. E., Yusmawan, W. & Yunika, K. (2018). Perbedaan Skor Rsi Penderita Laryngopharyngeal Reflux Yang Mendapat Omeprzole Dan Lansoprazole. Diponegoro Medical Journal (Jurnal Kedokteran Diponegoro) 7(1), 348–358.
Sa'an, B. & N. (2017). Gambaran Pasien Laryngopharyngeal Reflux di Bagian Poliklinik THT-KL RSUP Dr. M. Djamil Padang Periode. Jurnal Ilmu Kesehatan Indonesia (2) 1.
Satish, D., Datta, H. C. B., Manjula, B. V., Poojari, B. A. & Molluru, B. R. (2016). Correlation between reflux symptom index and reflux finding score in patients with laryngopharyngeal reflux: Our experience. Journal of Advanced Clinical & Research Insights 3(1), 13–17. Retrieved from https://dx.doi.org/10.15713/ins.jcri.96 10.15713/ins.jcri.96 DOI: https://doi.org/10.15713/ins.jcri.96
Silva, Á. S., Duprat, A. C., Machado, S. R., Melo, D. N. & Nascimento Ribeiro, D. K. (2021). Evaluation of the Reflux Symptom Index and the Endolaryngeal Findings Scale after Treatment in Individuals with Laryngopharyngeal Reflux. International Archives of Otorhinolaryngology 25(01), e115–e122. Retrieved from https://dx.doi.org/10.1055/s-0040-1702967 10.1055/s-0040-1702967 DOI: https://doi.org/10.1055/s-0040-1702967
Sirin, S. & Öz, F. (2019). Laryngopharyngeal reflux concept: what is known and what should we focus on? Brazilian Journal of Otorhinolaryngology 85(2), 133–135. Retrieved from https://dx.doi.org/10.1016/j.bjorl.2019.01.001 10.1016/j.bjorl.2019.01.001 DOI: https://doi.org/10.1016/j.bjorl.2019.01.001
Somashekara, K. G. & Kamath, G. J. (2015). Clinical Evaluation of Cases of Laryngopharyngeal Reflux. Indian J Appl Res 5, 336–344.
Stinnett, S., Dhillon, V. & Akst, L. (2018). Laryngopharyngeal Reflux: Current Concepts on Etiology and Pathophysiology and Its Role in Dysphagia. Current Otorhinolaryngology Reports 6(2), 196–202. Retrieved from https://dx.doi.org/10.1007/s40136-018-0192-6 10.1007/s40136-018-0192-6 DOI: https://doi.org/10.1007/s40136-018-0192-6
Sung, C. K. & Reflux, Laryngopharyngeal Reflux ( LPR ) Protocol. LPR ) Protocol. Available . Retrieved from https://med.stanford.edu/content/dam/sm/ohns/documents/voicecenter/resources/Stanford_ENT_Clinic-LPR_Protocol.pdf
Tussakinah, W., Masrul, M. & Burhan, I. R. (2017). Hubungan Pola Makan dan Tingkat Stres terhadap Kekambuhan Gastritis di Wilayah Kerja Puskesmas Tarok Kota Payakumbuh Tahun. Jurnal Kesehatan Andalas 7(2), 217–225. DOI: https://doi.org/10.25077/jka.v7i2.805
Wilson, R. L. & Stevenson, C. E. (2019). Anatomy and physiology of the stomach. Shackelford's Surgery of the Alimentary Tract, 2 Volume Set 634–646. DOI: https://doi.org/10.1016/B978-0-323-40232-3.00056-X
Zildzic, M., Masic, I., Salihefendic, N., Jasic, M. & Hajdarevic, B. (2020). The Importance of Nutrition in Boosting Immunity for Prevention and Treatment COVID-19. International Journal on Biomedicine and Healthcare 8(2), 73. Retrieved from https://dx.doi.org/10.5455/ijbh.2020.8.73-79 10.5455/ijbh.2020.8.73-79 DOI: https://doi.org/10.5455/ijbh.2020.8.73-79
Zildzic, M., Masic, I., Salihefendic, N., Jasic, M. & Hajdarevic, B. (2020). The Importance of Nutrition in Boosting Immunity for Prevention and Treatment COVID-19. International Journal on Biomedicine and Healthcare 8(2), 73. Retrieved from https://dx.doi.org/10.5455/ijbh.2020.8.73-79 10.5455/ijbh.2020.8.73-79 DOI: https://doi.org/10.5455/ijbh.2020.8.73-79
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Lina Marlina, Fransiskus Harf Poluan, Ribka Liliana Zebua
This work is licensed under a Creative Commons Attribution 4.0 International License.
With the licence CC-BY, authors retain the copyright, allowing anyone to download, reuse, re-print, modify, distribute, and/or copy their contribution. The work must be properly attributed to its author.
It is not necessary to ask for further permission from the author or journal board.
This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge.
