A Review study on Small differentiative between Oral Contraceptives (Progestin-only pills/ combined hormonal pills)
Khushi Upadhyay 1, Shaily Tyagi
2 , Ompi Kumari 3, Soumya Bharadwaj 3
1 Research
Scholar, Quantum University, Roorkee, India
2 Assistant
Professor, Quantum University, Roorkee, India
3Assistant Professor, Lord Buddha Koshi Pharmacy College, Baijnathpur, Saharsa, Bihar, India
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ABSTRACT |
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Oral contraceptive pills, are commonly used drugs to manage a number of reproductive health issues and prevent unwanted births. They are divided into two main categories: progestin-only pills (POPs) and combined oral contraceptives (COCs), which contain synthetic estrogen and progestin. In order to stop conception and implantation, COCs mainly function by suppressing ovulation, thickening cervical mucus, and changing the endometrial lining. Numerous
people utilize contraceptives; according to 2019 statistics, 790 million
(42%) use the traditional technique. The most popular methods of birth
control are female sterilization and male condoms, which are used by 922
million women of reproductive age worldwide. According to 2019 data, 219
million of these women (24%), and 189 million of them (21%), use female
sterilization and male condoms, respectively. Since 1994, the use of IUDs and
conventional procedures has decreased globally. The WHO states that the
condom is the only method of birth control that can prevent both unwanted
pregnancies and STDs. Between 2015 and
2020, the need for family planning increased by 77% worldwide. In 2020, there
will be 2000 million women who have used family planning methods, up from 900
million in the previous 20 years. The number of people using modern
contraceptive techniques has likewise climbed from 663 million to 851
million, with a 47.7% to 49.0% prevalence rate. Numerous types of birth
control are available, including hormonal treatments, which include CHC
vaginal rings, CHC transdermal patches, and combination hormonal contraceptives.
IUDs with progestin, DMPA injections, implants, progestin-only pills, and
hormonal male contraceptives are examples of progestin-only techniques. The
other approach is non-hormonal and involves vaginal pH modulators, barrier
techniques like condoms, and copper IUDs. |
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Received 11 November 2024 Accepted 16 December 2024 Published 31 January 2025 Corresponding Author Shaily
Tyagi, shailytyagi664@gmail.com DOI 10.29121/granthaalayah.v13.i1.2025.5903 Funding: This research
received no specific grant from any funding agency in the public, commercial,
or not-for-profit sectors. Copyright: © 2025 The
Author(s). This work is licensed under a Creative Commons
Attribution 4.0 International License. With the
license CC-BY, authors retain the copyright, allowing anyone to download,
reuse, re-print, modify, distribute, and/or copy their contribution. The work
must be properly attributed to its author. |
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Keywords: Combined Oral Contraceptives, Oral
Contraceptives, Birth Control Pills, Hormonal Contraceptives, Mini Pills |
1. INTRODUCTION
One common form of birth control that gives women an efficient way to avoid getting pregnant is oral contraceptive pills, or OCPs. These drugs are taken orally, and their main mechanism of action is to change a woman's hormone balance. Oral contraceptives have revolutionized reproductive health since their invention, providing not only contraception but also other health advantages.
Oral contraceptives that are combined (COCs): They include two hormones: progestin, a synthetic version of progesterone, and estrogen, typically ethinyl estradiol. Function by weakening the uterine lining, thickening cervical mucus, and inhibiting ovulation.
Triphasic (changing hormone levels throughout the cycle), biphasic, and monophasic (continuous hormone levels) are among the several formulations that are available. Usually taken for 21 days, with a 7-day placebo or hormone-free break in between to allow for withdrawal symptoms.
1.1. Progestin-only pills
Progestin only pills are appropriate for women who are unable to utilize estrogen because they solely contain progestin (such as nursing mothers or those who have a history of blood clots). They mainly by weakening the uterine lining and thickening cervical mucus, with less reliable ovulation suppression. The progestin-only pill (POP), sometimes referred to as the mini-pill, is a kind of oral contraception that doesn't contain estrogen and only contains progestin, a synthetic form of progesterone. It is frequently used as a form of birth control, particularly for women who are unable to use estrogen-containing methods. Sperm cannot access the uterus because POPs thicken the cervical mucus. POPs inhibit ovulation, or the release of an egg, in certain women. Comparing this effect to combined oral contraceptives, however, shows less consistency.
2. HORMONAL CONTRACEPTIVES
2.1. Combined hormonal contraceptives
It includes the combination of synthetic estrogen and progestins. Its failure rate is less than 1% with the proper prescribed use and 7% to 9% with typical unprescribed use. These are most often prescribed by medical practitioner. Progestin prevents the release of eggs from ovaries by inhibiting LH surge, results in suppressed ovulation. They thicken the cervical mucus and makes the endometrium atrophic. Estrogen suppress FSH production, results in inhibition of development of dominant follicle. CHCs are basically taken for three weeks. Withdrawal bleeding takes place after three weeks that may assure that user is not pregnant.
Common side effects of CHCs includes shorter menstrual cycle, reduction in menstrual flow upto 40% to 50%, nausea, breast tenderness, headaches, emotional stress, irregular bleeding, reduced PMS.
2.2. Some disadvantages like
· POPs need to be taken at the same time every day, three hours apart (or twelve hours apart for certain more recent POPs, such as tablets that include desogestrel).
· Spotting, irregular periods, or amenorrhea (lack of periods) are common adverse effects.
· Its efficacy may be less than that of combined oral contraceptives if improperly used.
CHCs pills: These pills are available in markets easily; they contain the combinational salt of 10 to 35 mcg ethinyl estradiol and a generation of progestins. Theses pills should be taken at same time every day, if the dose is missed then user should take the dose as soon as they remember, the gap of more than 48 hours between missing dose do not assure the ovulation suppression, missing of a pill will have effect on effectiveness of the pill. In case if the dose is missed the backup contraceptive method should be used for 7 days to prevent pregnancy.
Major disadvantages of hormonal pills:
· They do not protect against sexually transmitted diseases.
· Doses should not be missed.
· Irregular bleeding, low menstrual flow.
· Women with high BP cannot take these pills.
· These pills can often cause cycle irregularities.
CHC transdermal patch: it is a thin square of 2 inches, it contains the combinational salt of 150 mcg norelgestromin and 35 mcg ethinyl estradiol. It can be placed anywhere like stomach arm buttocks and is should be completely attached on the skin for maximum effective results. It is used for three weeks and is replaced every week for up to three weeks.
Major disadvantages:
· It does not protect against sexually transmitted diseases.
· Irregular bleeding
· It can cause reactions and side effects like headaches, nausea etc.
· Can skin reactions like irritation.
3. Difference between Progestin only pills or Combined Hormonal Pill
1) Progestin
Pills:
They do not contain estrogen; it only contains progestin, a synthetic version of the Hormone progesterone.
To stop sperm from getting to the egg, cervical mucus is thickened.
lessens the chance of implantation by thinning the lining of the uterus.
suppresses ovulation in certain situations (but not as frequently as CHCs).
Women with a history of blood clots, lactation, migraines with aura, or other contraindications to estrogen, or those who are unable to take it.
It must be taken daily at the same time. Delays of even a few hours can lessen their efficacy. Side effects could include spotting, irregular bleeding, or no periods at all. Strict scheduling is necessary; it must be taken daily at the same time within a window of only three hours (some more recent POPs permit up to twelve hours).
2) Combined
Hormonal pill:
Both progestin and estrogen are present in its composition.
Consistently stops ovulation by inhibiting the ovaries' ability to release eggs.
thins the uterine lining and thickens cervical mucus (similar to POPs).
Women who don't have any estrogen contraindications and who want normal menstrual cycles or extra benefits (such lighter periods or less acne).
More adaptable than POPs; protection is usually maintained even if a dose is missed
For up to 12 hours. Side effects include breast pain, nausea, and an elevated chance of blood clots; however, most women have a low risk of this.
Women with estrogen contraindications (such as a history of thromboembolic events, migraines with aura, uncontrolled hypertension, etc.) are not advised to use this medication.
The majority of sexually active women, particularly those in their teens, are quite concerned about preventing unwanted pregnancies. Eighty-one percent of women between the ages of 15 and 19 who were at risk of becoming pregnant unintentionally were estimated to have used contraceptive techniques in 1995; many of them reported using two methods: one as a contraceptive method and the other to prevent sexually transmitted diseases (STDs). Male condoms accounted for 46% of the instances, oral contraceptives for 44% of the cases, or both systems for 8% of the cases. However, user compliance is crucial to the success of these techniques. Particularly with teenagers, the issues include improper pill consumption or not using a condom right before sex.
Table 1
Table 1 Feature Progestin-Only Pills (POPs) And Combined Hormonal Pills (CHCs) |
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Hormones |
Progestin only |
Estrogen + Progestin |
Mechanism: |
Thickens mucus, thins uterine lining, sometimes inhibits ovulation |
Consistently inhibits ovulation, thickens mucus, thins uterine
lining |
Timing Strictness |
Very strict (3-12 hours) |
More forgiving (24 hours) |
Bleeding Patterns |
Irregular or no periods |
Regular, predictable periods |
The availability of fake medications on the illicit market is influenced by a number of factors, according to the World Health Organization (WHO). These causes include inadequate national regulations for the production and distribution of drugs, lax enforcement of drug laws, inadequate penalties for drug law infractions, and inadequate regulation among exporting nations. The intricate transactions involving numerous middlemen, the high demand and expense for preventative and curative medications, and the ineffective cooperation of stakeholders are additional significant reasons.
The ease of getting prescription goods from online platforms and their relatively reduced prices compared to products purchased from conventional pharmacies are the main reasons for the growing popularity of online pharmacies. However, a significant public health concern has been the quality of prescription medications purchased online. Furthermore, it may be doubtful if internet pharmacies that sell prescription medications are legitimate. Most significantly, there are worries about consumer safety because improper prescription medication use may be harmful. Thus, the current study focused on three key topics in order to do a systematic analysis of online pharmacies: the nature and traits of internet pharmacies; the caliber of prescription medications bought online; and the traits of customers buying prescription medications.
CONFLICT OF INTERESTS
None.
ACKNOWLEDGMENTS
None.
REFERENCES
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