0BWHAT WILL HAPPEN TO NUMBER OF THE INFECTED IF ACCURACY OF THE PCR TEST IMPROVES?Yasunori Fujita 1 1B1 Keio University, Japan. |
|
||
|
|||
Received 17 September 2021 Accepted 18
October 2021 Published 31 October 2021 Corresponding Author Yasunori
Fujita, yfujita@econ.keio.ac.jp DOI 10.29121/granthaalayah.v9.i10.2021.4305 Funding:
This
research received no specific grant from any funding agency in the public,
commercial, or not-for-profit sectors. Copyright:
© 2021
The Author(s). This is an open access article distributed under the terms of
the Creative Commons Attribution License, which permits unrestricted use, distribution,
and reproduction in any medium, provided the original author and source are
credited. |
ABSTRACT |
|
|
Among
the strategies to tackle the COVID-19, much attention is paid to “test and
isolation” advocated by Romer (2000), Peto et al (2020) etc., in addition to
vaccination and development of medicines to treat COVID-19. According to
these articles, what is necessary is a targeted version of lockdown, that is,
to test everyone regularly and isolate the small fraction of the population
who test positive. There
is, however, concern that the PCR test is not always effective, so that, in
the present paper, we investigate the effects of improvement of the PCR test
by constructing a simple intertemporal theoretical model. Main result we
obtain is that improvement of the PCR test could increase the number of the
infected individuals at first, so that we should improve the accuracy of the
PCR test much enough to reduce the number of the infected individuals. |
|
||
Keywords: COVID-19,
Accuracy of The PCR Test, Antibody, Steady State Number of The Infected
Individuals, Transmission Rate of The Coronavirus 1. INTRODUCTION Among the strategies to
tackle the COVID-19, much attention is paid to “test and isolation” advocated
by Romer (2020), Peto et al. (2020) etc., in
addition to vaccination and development of medicines to treat COVID-19.
According to these articles, what is necessary is a targeted version of
lockdown, that is, to test everyone regularly and isolate the small fraction
of the population who test positive. There is, however,
concern that the PCR test is not always effective, so that, in the present
paper, we investigate the effects of improvement of the PCR test by
constructing a simple intertemporal theoretical model, extending theoretical
models such as Fujita (2020a), Fujita (2020b), Fujita (2020c), Fujita (2021a), Fujita (2021b). The present
paper is also inspired by numerous empirical studies, which revealed the
impacts of the COVID-19 on various economic aspects such as consumption,
stock market, uncertainty, tax policy, leadership styles and so on Baker et al. (2020), Baker et al. (2020), Baker et al. (2020), Watanabe (2020), Bandara and
Weerasooriya (2021), Ramadhanti and
Kularajasingham (2021). In the present paper, we investigate what will happen to number of the
infected if accuracy of the PCR test improves. Different from Fujita (2021a), which analyzed
the consequence of prevention measures such as vaccination, and Fujita (2021b), which focused
on the treatment of the patients who had positive PCR |
|
||
test, the present paper focuses on the improvement of the PCR test by incorporating the antibodies.
Structure of this paper is as follows. Section 2 lays out the basic model and section 3 derives the number of the infected individuals in the steady state. Concluding remarks are made in section 4.
2. BASIC MODEL
Let us consider an
intertemporal economy where time passes continuously and the time horizon is
infinite. The economy consists of N
(>0) individuals, of whom x(t) individuals in period t are infected with the coronavirus but
do not to present symptoms. We assume that every individual takes the PCR test
in every period, which is incomplete in a sense that p×100 % of theinfected individuals x(t),
i.e., px(t), are falsely judged to be negative. We also assume that those
who tested positive get treatments and are allowed to go out for work, shopping
etc., but can be infected again in the same period.
As a characteristic
of the present paper, we assume that, in period t, among those who are not infected, θpx(t) individuals
develop antibodies, where θ is a
positive constant, meaning the more the infected individuals, the more
individuals develop antibodies.
By assuming
each of those who are infected but judged to be negative transmits the virus to
α individuals in period t, of whom a fraction of 1 is
newly infected since is
infected and has
developed antibody already, we can express the motion of number of the infected
individuals as.
x(t+1) =px(t)+px(t)α {1}. (1)
3. RESULTS AND DISCUSSIONS
Letting x* denote the steady state number of the
infected individuals and substituting x(t+1) =x(t)=x* into equation (1), we have the condition x* should satisfy as
x* =px*[1+α {1}], (2)
and by solving x* with respect to (2), we obtain
. (3)
Since x*, the steady state number of the
infected people, should be less than N-θpx*, steady
state number of those who can be infected, we have the condition
x* should satisfy
as
. (4)
If (4) is
satisfied, the following inequality is also satisfied since p, the failure probability, is less than
1:
, (5)
which is
derived by the condition that 1 in
equation (2) should be nonnegative.
Considering
(3)-(5), we can draw a relationship between p
and x* typically as a graph, which is
the combination of (3), curve-segment AB, and (,
which is the part of (4)), curve-segment BC, as in Figure 1 on the p-x*
plane.
|
Figure 1 Relationship between failure
probability and steady state number of the infected |
By paying
attention to the region around point C,
we have the following proposition.
Proposition:
The steady state number of the infected
people, x*, increases if the failure
probability of PCR test decreases from 1
From this proposition, we can say that we should improve the accuracy of the PCR test much enough to reduce the number of the infected individuals since the improvement of the PCR test increases the number of the infected individuals at first.
4. CONCLUSIONS
The present study theoretically investigated the effects of improvement of the PCR test, to obtain the result that accuracy of the PCR test should be improved much enough to reduce the number of the infected individuals since the improvement of the PCR test increases the number of the infected individuals at first.
It is necessary to examine the robustness of our results in a more general framework that incorporates the economic activities. It is also of interest to investigate the compound effects of the PCR test, the vaccination and the treatment of COVID-19. We will conduct such analyses in the next paper.
REFERENCES
Baker S. R., Bloom, N., Davis, S.J., Kost, K.J., Sammon, M.C. and Viratyosin, T (2020) The Unprecedented Stock Market Impact of Covid-19, NBER Working Paper Series 26945. Retrieved from https://doi.org/10.3386/w26945
Baker, S.R., Bloom, N., Davis, S.J. and Terry, S.J. (2020) COVID-induced Economic Uncertainty, NBER Working Paper Series 26983. Retrieved from https://doi.org/10.3386/w26983
Baker, S.R., Farrokhnia R.A., Meyer, S. Pagel, M. and Yannelis, C. (2020) How does Household Spending Respond to an Epidemic? Consumption during the 2020 Covid-19 Pandemic, NBER Working Paper Series 26949. Retrieved from https://doi.org/10.3386/w26949
Bandara, K. G. A. G. and Weerasooriya, W. M. R. B. (2021) A Study between the Taxpayers' Perception toward the Tax Policy Changes and the Tax Compliance in Sri Lanka: A Tax Relief in Response to the Impact of Covid-19 Epidemic, and its Implications, Business, Management and Economics Research, vol. 7(2), 52-64. Retrieved from https://doi.org/10.32861/bmer.72.52.64
Fujita, Y. (2020a) When Should We Start the Lockdown and How Long Should it be?, Modern Economy, 11, 1007-1011. Retrieved from https://doi.org/10.4236/me.2020.115075
Fujita, Y. (2020b) How Much should Government Compensate Firms for Suspension of their Businesses in ORDER to Fight Off the New Coronavirus?, Theoretical Economics Letters, 10, 600-606. Retrieved from https://doi.org/10.4236/tel.2020.103038
Fujita, Y. (2020c) How could We Prevent Spread of the Coronavirus without Deteriorating Economy?, Modern Economy, 11, 1280-1287. Retrieved from https://doi.org/10.4236/me.2020.117091
Fujita, Y. (2021a) Does Vaccinations Reduce the COVID-19 Infection?, Archives of Business Research, forthcoming. Retrieved from https://doi.org/10.14738/abr.98.10608
Fujita, Y. (2021b) Better than Nothing?: Consequence of Incomplete Treatment of COVID-19, Business Management and Economics Research, forthcoming. Retrieved from https://doi.org/10.5430/bmr.v10n3p11
Peto, J., et al. (2020) Stopping the Lockdown and Ending the Epidemic by Universal Weekly Testing as the Exit Strategy, Retrieved from https://ephg-covid-19.org/
Ramadhanti, T., Singh, J. S. K. and Kularajasingham, J. (2021) Transactional and Transformational Leadership Styles as Predictors of Employee Performance during the Covid-19 Crisis and the Mediating Role of Organisational Culture, Business, Management and Economics Research, vol. 7(2), 39-51. Retrieved from https://doi.org/10.32861/bmer.72.39.51
Romer, P. (2020) Roadmap to Responsibly Reopen America, Retrieved from https://roadmap.paulromer.net/
Watanabe, T. (2020) The Responses of Consumption and Prices in Japan to the COVID-19 Crisis and the Tohoku Earthquake, Working Paper Series, CARF-F-476. Retrieved from https://doi.org/10.7916/d8-qs4v-q792
This work is licensed under a: Creative Commons Attribution 4.0 International License
© Granthaalayah 2014-2021. All Rights Reserved.