WUHAN COVID-19 SYNTHETIC ORIGINS AND EVOLUTION

The main result of this updated release is the formal proof that 2019-nCoV coronavirus is partially a SYNTHETIC genome. We proof the CONCENTRATION in a small région of wuhan New genome (300bp) of 3 different régions from HIV1 ENVELOPPE gene and 3 others from HIV2 and SIV (ENV and POL RT). All this is remarkable and bears the mark of a desire for organization of a human nature: LOGIC, SYMETRIES. 
In this article, we demonstrate also that there is a kind of global human hosts adaptation strategy of SARS viruses as well as a strategy of global evolution of the genomes of the different strains of SARS which have emerged, mainly in China, between years 2003 first SARS genomes and the last 2019 COVID-19 Wuhan seafood market pneumonia virus isolate Wuhan-Hu-1, complete genome. 
This global strategy, this temporal link, is materialized in our demonstration by highlighting stationary numerical waves controlling the entire sequence of their genomes. 
Curiously, these digital waves characterizing the 9 SARS genomes studied here are characteristic whole numbers: the "Fibonacci numbers", omnipresent in the forms of Nature, and which our research for several decades has shown strong links with the proportions of nucleotides in DNA. 
Here we demonstrate that the complexity and fractal multiplicity of these Fibonacci numerical waves increases over the years of the emergence of new SARS strains. 
We suggest that this increase in the overall organization of the SARS genomes over the years reflects a better adaptation of SARS genomes to the human host. 
The question of a link with pathogenicity remains open. 
However, we believe that this overall strategy for the evolution of the SARS genomes ensures greater unity, consistency and integrity of the genome. 
Finally, we ask ourselves the question of a possible artificial origin of this genome, in particular because of the presence of fragments of HIV1, HIV2 and SIV retroviruses.


Introduction
"Where there is matter, there is geometry. " -Johannes Kepler Since the SARS coronavirus emergence 18 years ago, a large number of severe acute respiratory syndrome related coronaviruses (SARSr-CoV) have been discovered in their natural host, bats. Some of those bat SARSr-CoVs have the potential to infect humans. In january 2020, Wuhan China megacity was the origin of a Novel SARS disease entitled by OMS « COVID-19 » [6]. This novel coronavirus (COVID- 19) caused an epidemic of respiratory syndrome in humans, in Wuhan, China then in other World countries (Iran South Korea, Italia...). As show in the following figures, we analyse in this article 9 whole SARS genomes with the goal to discover a possible strategy of SARS GENOMES EVOLUTION from 2003 original viruses to the 2020 WUHAN virus. Secondly, for about 30 years, we have been looking for possible global, even digital, structures that would organize DNA, genes, chromosomes, and even whole genomes [27,28,30,50,51].
however, it is only by deepening the notion of "fractal periodicity", outlined in [7,38], and we will highlight here that we have re-discovered the major role of Fibonacci fractal stationary waves at both scales of each whole individual chromosomes and whole genome. We then demonstrate a sort of "hierarchical classification" of the 24 chromosomes. In this hierarchy, the chromosome4 seems to play a major and privileged role.
By comparing chromosome, the 3 reference genomes of Neanderthal, Sapiens BUILD34 of 2003 and Sapiens HG38 of 2013, we demonstrate the evidence of « fractal periods » and « Resonance periods» characterizing each of the 24 human chromosomes [47]. As illustrated in Figure1 below, these resonances make it possible to differentiate the respective genomes of Neanderthal and Sapiens on the global scale of the chromosome (here chromosome 4). Here, a resonance of 34 nucleotides is common to both chromosomes 4 of Sapiens and Neanderthal, however, the respective forms of these resonance curves are radically different. Figure 2: As will be demonstrated here, the 2 respective Chromosomes 4 of Neanderthal and Sapiens HG38 share a "resonance" of 34 bp, however, these two radically different resonance curves illustrate a major differentiation of the 2 human species at the GLOBAL scale of chromosome 4.

Methods
The 9 Analysed Genomes:

Computing Fractal Periods and Resonances Summary
The complete description of this method can be found in [47], We introduce here a method of global analysis of the roughness or fractal texture of the DNA sequences at the chromosome scale. To do this, we generalize the method of numerical analysis of the "Master Code of Biology" [39][40][41][42]44]. Thus, we restructure the sequence into different generic sequences based on "meta codons" no longer triplets of 3 nucleotides but values ranging from 17 to 377 nucleotides, i.e 360 simulations. This method of analysis will then reveal, in most cases, discrete waves or interferences, most often dissonances. However, sometimes there will emerge kinds of resonances where all scales of analysis appear to be in symbiosis.

Function:
The Genomics master code (-II-) is generalized to meta-codons that no longer have 3 nucleotides as a codon, but 4, 5, ... 377 nucleotides. Then we analyze the textures by the undulatory code (-IV-). It then appears dissonances and resonances that will reveal periods of discrete waves, resonances, and standing waves. The Genomics Binary code analysis (-III-) confirms these periods using a complementary independent method.
Inputs: Double strand DNA sequence Pi-mass grouped by meta-codons (each Pi-mass is = -1 times number of « G » bases in meta-codon double strand or also = -1 times number of « C+G » bases in single strand meta-codon.
Outputs: Period and resonance standing wave computed by two complementary methods. Summary: We introduce here a method of global analysis of the roughness or fractal texture of the DNA sequences at the chromosome scale. To do this, we generalize the method of numerical analysis of the "Master Code" . Thus, we restructure the sequence into different generic sequences based on "meta codons", no longer triplets of 3 nucleotides, but values ranging from 17 to 377 nucleotides, ie 360 simulations. This method of analysis will then reveal, in most cases, discrete waves or interferences, most often dissonances (based on Genomics Undulatory waves described here in . However, sometimes there will emerge kinds of resonances where all scales of analysis appear to be in symbiosis.

Process:
The discrete interferences fields resulting from the analysis of an entire chromosome are therefore a three-dimensional space: Dim y (vertical) restructuring in meta codons of lengths 17 to 377 nucleotides (or in this Coronavirus article meta codons 1bp to 100bp) Dim x (horizontal) Leibnitz differentiations such that primary 1/2 secondary 1/3... 1/4 ... 1 / n Dim z cumulated populations from the "Master code" operators. The + 1 / -1 derivatives will be of type increase, ie +1 if derivative increasing and will be of type decrease, ie -1 if derived decreasing. In this context we will explore these 3D spaces in 2 forms: • Horizontally [47 -IV-], meta codons dimension: curves for a given meta codon dimension, see in the example "resonances" below (see Figure 3 and Figure 4). • Vertically [47 -III-], spectral differentiation: discrete series d2-d1 is +1 if increase and -1 if decrease (see Figure 5). We represent in top the +1 and in low the -1, (see Figure 5).   These two independent methods lead in all the cases analyzed to the same period value: here, for example, the period "horizontal scan" is a resonance of 22bp (Figure 4) and the period "vertical scan" is a period of repeatability of 22bp also ( Figure 5). A third complementary method is presented here: knowing the period determined and confirmed by the two previous methods, we segment the complete sequence of the chromosome by consecutive segments according to this period, for example here for the chromosome21, we will "cut" the entire sequence of the chromosome in successive sections of 22 bases, the length of the period discovered. Then we record for each segment the C + G populations on the one hand and T + A on the other hand. We then represent the cumulative distribution curve of these different CG and TA populations throughout the chromosome sequence.
We then represent the cumulative distribution curve of these different CG and TA populations throughout the chromosome sequence (Table2).

Results and Discussion
• SARS2003

SARS Coronavirus ZS-C, Complete Genome
https://www.ncbi.nlm.nih.gov/nuccore/AY395003 Http://www.granthaalayah.com ©International Journal of Research -GRANTHAALAYAH [297] In this third SARS2004b genome, we find only the Fibonacci stationary wave 5bp ( Figure 15). All other fractal waves 8,13, 21 bp are absent. Http://www.granthaalayah.com ©International Journal of Research -GRANTHAALAYAH [302] In this sixth SARS2017 genome, we find also three Fractal Fibonacci stationary wave 5bp, 8bp, and 13bp (Figures 26, 27, 28). Meanwhile the fourth other fractal wave 21 bp remain absent. In this seventh WUHANOLD 12 January 2020 genome, we find also three Fractal Fibonacci stationary wave 5bp, 8bp, and 13bp (Figures 29, 30, 31). Now the fourth other fractal wave 21 bp is also present ( Figure 33). In this eighth WUHAN2 14 January 2020 genome, we find also three Fractal Fibonacci stationary wave 5bp, 8bp, and 13bp (Figures 33, 34, 35). Now the fourth other fractal wave 21 bp is also present ( Figure 36). In this last and ninth reference WUHAN 23 January 2020 genome, we find also three Fractal Fibonacci stationary wave 5bp, 8bp, and 13bp (Figures 39, 40, 41). Now the fourth other fractal wave 21 bp is also present ( Figure 42). Figure 43: A second method of highlighting the standing wave of period 21bp. In figure 44 we have superimposed the standing waves of 21bp corresponding to the 3 published versions of the wuhan genome of 2020. There appears a very high sensitivity, which suggests the fact that this new genome is in full phase of evolution in its adaptation to the human host.

How Could Tomorrow 2019-Ncov Evolve?
In [2] and [5], authors show that there is no doubt that 2019-nCoV is a novel unknown sequence.
In an unformal draft, Dr Lyons-weiler [4] even suggests that a region between the bases 21600-22350 bp would be completely new. Considering that this region could be "foreign" to the family of coronaviruses we tried to test how its absence could have had an impact on the waves that we reveal here. We then construct a hypothetical genome which would no longer have this insertion between the bases 21600-22350 bp. It then appears (Figure 45  1 / symbiosis strategy by complementarity: example of HIV more frequently integrating chromosomes 20 16 17 22 19. These chromosomes have a poor HGO (Human Genome Optimum) ratio, it will be slightly improved by the integration of the virus.
Indeed, in [8,46], we demonstrated why the permeability to the integration of retrovirus in each of our chromosomes is correlated with this classification HGO (HUMAN GENOME OPTIMUM) of this article http://www.imedpub.com/abstract/towards-a-universal-law-controlling-all-humancancer-chromosome-loh-deletions-perspectives-in-prostate-and-breast-cancers-screening-20846  We also see in figure 47 from Figure 4 (Wang 2007), that these chromosomes are very permeable to the HIV retrovirus (Dark green bands in the following image from [3]. Finally, we have recognized here 2 laws of symbiosis of nature: agreement because very DIFFERENT, and agreement because very SIMILAR. Strategies that we find up to the affinities between humans ...!!! If the genome of the 2019-nCoV retrovirus has adopted this second strategy of integration into the human genome, this could explain the fact observed at the beginning of 2020: a moderately pathogenic virus but which spreads very quickly ... Because its retrovirus would be judiciously adapted to its (supposed) host chromosome4 of the human genome?

On A Possible Origin Of 2019-Ncov Genome:
It is very likely that there was HUMAN INTERVENTION in this LYONS's region [4] of wuhan genome: Analysis of this region in all coronaviruses shows a 100% jump in homology for the Wuhan genomes and 70 to 80% for the closest SARS. Although there is already a trace of ENV HIV1 in the genome that we have referenced here SARS2003.  To Conclude: Figure 48: Double level of correlation between the years of emergence of the SARS virus, the presence of standing Fibonacci fractal waves, and the Fractal number of nested and embedded Fibonacci layers.
One track that will need to be deepened is that of integrating the SARS coronavirus genome into human chromosomes [9,57].
Indeed, if we show that each of the 24 human chromosomes is characterized by one or more specific standing waves, some of our chromosomes (chromosomes 4 and 13 for example) have standing waves which are Fibonacci numbers [7]. There could then be a kind of harmonic agreement between the genome of the SARS virus and its human host chromosome, both of which have standing Fibonacci waves, which will facilitate and strengthen the integration and persistence of these viruses in humans.
Finally, That is a formal proof of an evolution increasing global structure of SARS whole genomes, probably linked with genome integrity and coherence and, human génome adaptation [8,38] , perhaps pathogenicity.

Evidence of A Kind of "Intelligent Will" ...
Please, now, see figures 49 then 50.
Both figures proves evidence that the 6 HIV/SIV inserts are not the result of natural evolution and mutations. Particularly, • Firstly, the 6 inserts are highly contiguous: 169bp within 275bp regions.

Ethical Considerations:
The 2 main results of this publication confront us with a paradox, in fact: On the one hand, we have just demonstrated that this covid-19 genome contains an insertion of 6 strategic regions of HIV / SIV concentrated in a mini space representing less than 1% of the length of the genome. One can think that such a "disturbance" can only have affected the global order of the DNA of this genome.
On the other hand, we have also just shown that since the first SARS of 2003, the global order of successive genomes was only increasing, highlighted here by stationary digital waves calibrated on increasing Fibonacci numbers. In particular, covid-19 is structured over a long distance by a 21bp amplitude wave. However, the deletion in this genome of the small region including the 6 HIV / SIV inserts, will further gain in organization, causing waves of 34 bp to emerge (the number of Fibonacci following 21 bp). We must conclude this remarkable fact: To adapt to the disorder of its DNA resulting from the insertion of the 6 HIV / SIVs, the covid-19 genome has most certainly increased its level of global organization by adaptation mutations.
And we will now have to fear that this genome will continue to mutate in order to optimize its overall level of organization ...