BIOLOGICAL EVALUATION OF GLYCOGEN SYNTHASE KINASE-3 Β INHIBITORS AS ANTIDIABETIC AGENT

  • Jeeven S. Solanki Department of Chemistry, Govt. Madhav Science P.G. College Ujjain (M.P.) Pin 456010, India
  • Arpan Bhardwaj Department of Chemistry, Govt. Madhav Science P.G. College Ujjain (M.P.) Pin 456010, India
  • Amit Padidar Department of Chemistry, Govt. Madhav Science P.G. College Ujjain (M.P.) Pin 456010, India
  • Kalpana Singh Department of Chemistry, Govt. Madhav Science P.G. College Ujjain (M.P.) Pin 456010, India
  • Rekha Nagwanshi Department of Chemistry, Govt. Madhav Science P.G. College Ujjain (M.P.) Pin 456010, India
Keywords: Phenylmethylenehydantoin, Phenylmethylenerhodanine, Antidiabetic, GSK-3β

Abstract

A series of phenylmethylenehydantoin and phenylmethylenerhodanine derivatives (Der 1 to
Der 8) were synthesized. These newly synthesized derivatives have been characterized by
elemental analysis molecular weight measurements as well as spectral (IR, 1H NMR
13CNMR) studies. All the compounds show significant increase in liver glycogen level at 25
mg/kg dose levels, in- vivo & these compounds were also screened for anti diabetic activity on
albino rats. Most of these compounds have shown significant antidiabetic activity at 25 mg/kg
dose levels.

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Published
2017-12-31
How to Cite
Solanki, J. S., Bhardwaj, A., Padidar , A., Singh, K., & Nagwanshi, R. (2017). BIOLOGICAL EVALUATION OF GLYCOGEN SYNTHASE KINASE-3 Β INHIBITORS AS ANTIDIABETIC AGENT. International Journal of Engineering Technologies and Management Research, 4(12), 1-12. https://doi.org/10.29121/ijetmr.v4.i12.2017.584