ELECTRONIC SPECTRAL CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY OF LANTHANIDE (III) - CEFTAZIDIME COMPLEXES
The present work describes the spectrochemical study of some Lanthanide (III) - ceftazidime (Ln(III)-CEFZ) complexes. The impact of the ligand environment on electronic spectrum of the lantanide ion with special reference to complexation and nature of Ln-ligand bond has been examined. The energy and intensity parameters for the complexes have also been evaluated. The ligand and all prepared complexes were screened for their antibacterial activities against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus and the results showed that antibacterial activity of ligand on complexation have been enhanced.
Pachori K, Malik S, Wankhede S. Synthesis, Characterization and Antimicrobial studies of Transition metal complexes of Co(II) and Ni(II)derived from Cefadroxil. Res. J. Chem. Sci. 2014; 4(2): 75-80.
Abo El-Maali N, Osman A.H, Aly A.A.M, et al. Voltammetric analysis of Cu (II), Cd (II) and Zn (II) complexes and their cyclic voltammetry with several cephalosporin antibiotics. Bioelectrochem. 2005; 65(2): 95–104. DOI: https://doi.org/10.1016/j.bioelechem.2004.09.002
Moreno A.H, Salgado H.R.N. Development and Validation of the Quantitative Analysis of Ceftazidime in Powder for Injection by Infrared Spectroscopy. Physical Chemistry. 2012; 2(1): 6- 11. DOI: https://doi.org/10.5923/j.pc.20120201.02
Mohamed G.G, Omar M.M, Hindy A.M. Metal Complexes of Schiff Bases: Preparation, Characterization, and Biological Activity.Turk. J. Chem. 2006; 30(3) : 361-382.
Abd E.I.W, and Sariag E.I. Derivatives of phosphate schiff base transition metal complexes: synthesis, studies and biological activity. Spectrochim. Acta. Mol. Biomol. Spectrosc. 2004; 60(1-2): 271-277. DOI: https://doi.org/10.1016/S1386-1425(03)00216-6
Paul J.D, Giann S. Metal-based anti-tumour drugs in the past genomic era. Dalton trans. 2006; 0(16):1929-1933.
Anacona J.R, Patiño C. Metalloantibiotics: Synthesis and antibacterial activity of ceftazidime metal complexes. J. Coord. Chem. 2009; 62(4): 613–621.
Muslu H, Golcu A, Ozkan S.A. Electrochemical study of ceftazidime-copper(II) complex: Synthesis, characterization, biological activity and analytical application to pharmaceutical dosage forms. Curr. Anal. Chem. 2010; 6(4): 299-309.
Patil S, Naik V.M, Bilehal D.C, et al. Synthesis, spectral and antimicrobial studies of lanthanide(III) nitrate complexes with tridentate ONO donor hydrazones. J. Exp. Sci. 2011; 2(7): 15-20.
Alabdaly B.I, Al-Almery M.H.A, Albayaty M.K. Synthesis, Characterization and Antibacterial Activity of New Complexes of Some Lanthanide Ions with Benzo 18-Crown-6 and 221-Cryptand .IOSR J. Appl. Chem. 2013; 6(4): 32-39.
Binnemans K, Deun R.V, Walrand C.G.R, et al. Spectroscopic behaviour of lanthanide(III) coordination compounds with Schi. base ligands. Phys. Chem. Chem. Phys. 2000; 2: 3753-3757.
Ranjana Devi N, Sumitra C, Rajmuhon N.S. Absorption Spectral Study of Pr(III) Complexes with L-Alanyl-L-Glutamine and N-Acetyl-L-Glutamine: Interaction Parameters, Bonding and Judd-Ofelt. Asian J. Chem. 2012; 24(7) : 2863-2870.
Monteiro J.H, S.K, Mazali I.O, Sigoli F.A. Determination of Judd-Ofelt Intensity Parameters of Pure Samarium(III) Complexes. J Fluoresc. 2011; 21(6): 2237. DOI: https://doi.org/10.1007/s10895-011-0928-x
Liu C, Liu J, Ofelt J. Intensity Parameters and Spectral Properties of Gd2O3:Eu3+Nanocrystals . J. Phys. Chem. B. 2006; 110 (41): 20277–20281.
Gudasi K.B, Havanur V.C, Patil S.A, Patil B.R. Antimicrobial Study of Newly Synthesized Lanthanide(III) Complexes of 2-[2-hydroxy-3-methoxyphenyl]-3-[2-hydroxy-3- methoxybenzylamino]-1,2-dihydroquinazolin-4(3H)-one. Met.-Based Drugs, 2007; 2007: 1-7.
Misra S.N, Gagnani M.A, Indira Devi M, Shukla R.S. Biological and Clinical Aspects of Lanthanide Coordination Compounds. Bioinorg Chem Appl. 2004; 2(3-4): 155-192. DOI: https://doi.org/10.1155/S1565363304000111
Wang B.D, Yang Z.Y, Wang Q, Cai T.K, Crewdson P. Synthesis, characterization, cytotoxic activities, and DNA-binding properties of the La(III) complex with Naringenin Schiff-base. Bioorg. Med. Chem. 2006; 14: 1880–1888.
Wang B.D, Yang Z.Y, Qin D.D, Chen Z.N. Synthesis, characterization, cytotoxic activity and DNA-binding properties of the Ln(III) complexes with ethylenediiminobi(6-hydroxychromone-3- carbaldehyde) Schiff-base. J. Photochem. Photobiol. A: Chem. 2008; 194: 49–58.
Li Y,Yang Z.Y,Wang M.F. Synthesis, characterization, DNA binding properties and antioxidant activity of Ln(III) complexes with hesperetin-4-one-(benzoyl) hydrazone. Eur. J. Med. Chem.2009; 44: 4585–4595.
Mishra R.K, Thakur B.G. Synthesis And Structural Investigation Of Some Trivalent Lanthanide Complexes Of Cloxacillin. AIJRFANS. 2014; 6(2): 130-135.
Kopacz M, Woenicka E, Gruszecka J. Antibacterial Activity of Morin and Its Complexes with La(III), Gd(III) And Lu(III) Ions. Acta Pol Pharm. 2005; 62(1): 65-67.
Sakhare M.A, Dhokte A.O, Bagal M.R, ArbadB.R. Spectral and antimicrobial studies on Nd(III), Sm(III) and Gd(III) complexes with a tetraaza macrocyclic ligand. AIJRFANS. 2013; 4(1): 47- 52.
Evans D.A, Muchi A.R, Stuermer R. Samarium (III)-Catalyzed Hydroboration of Olefins with Catecholborane: A General Approach to the Synthesis of Boronate Esters. J. Org. Chem. 1993; 58: 5307-5309.
Wen S, Zhang X, Hu S, Zhang L, Liu L. Influence of in-situ reaction on luminescent properties ofsamarium-complex/hydrogenated acrylonitrile-butadiene composites, Polymer. 2009; 50: 3269- 3274. DOI: https://doi.org/10.1016/j.polymer.2009.05.009
Santhi S, Namboori C.G.R, Int. Synthesis, Characterization and Antimicrobial Activity of Schiff Base Ligand Complexes of Sm(III), Gd(III) and Dy(III) ions. J. ChemTech Res. 2013; 5: 1750- 1755.
Al Momani W.M, Taha Z.A, Ajlouni, Abu Shaqra Q.M, Al Zouby M. A study of in vitro antibacterial activity of lanthanides complexes with a tetradentate Schiff base ligand. Asian pac J. Trop. Biomed. 2013; 3(5): 367-370.
Kostova I, Stefanova T. Synthesis, characterization and cytotoxic/cytostatic activity of Sm(III) and Gd(III) complexes. J. Coord. Chem. 2009; (62)19: 3187-3197. DOI: https://doi.org/10.1080/00958970903019509
Kostova I, Momekov G, Stancheva P.Met.-Based Drugs, New Samarium(III), Gadolinium(III), and Dysprosium(III) Complexes of Coumarin-3-Carboxylic Acid as Antiproliferative Agents. 2007; article ID 15925,1-8 DOI: https://doi.org/10.1155/2007/15925
Jain R, Bhatnagar M., Dakshene M. Electronic Spectral Characterization of Pr(III) Antibiotic Complexes in Solution, Asian Journal of Chemistry. 2010; 22 (10): 7739-7744.
Bhandari H.S, Mehla S.K, Soni M, Bhojak N. Res. Rev. Biological Evaluation of Some Amide Group Containing Ligands and Their Complexes with Gd (III) Ions. J. Chem. 2013; 2(4): 28-31.
Zhang J, Badger P.D, Geib S.J, Petoud S. Synthesis and Structural Properties of Lanthanide Complexes Formed with Tropolonate Ligands. Inorg. Chem. 2007; 46 (16): 6473–6482.
Leoncini A, Ansari A, Mohapatra P.K, Sengupta A, Huskens J, Verboom W. Diglycolamidefunctionalized poly(propylene imine) diaminobutane dendrimers for sequestration of trivalent felements: synthesis, extraction and complexation. Dalton Trans. 2017; 46: 501-508 . DOI: https://doi.org/10.1039/C6DT03648A
Chakraborti I, Goel N.,Synthesis and characterization of some hexa and nona-coordinated complexes of trivalent Lantanide(III) derived from 4[N-(4’-Dimethylaminobenzalidene)amino] Antipyrine Semicarbazone. Asian J. Chem. 2003; 15: 679-686.
Carnall W.T, Fields P.R, Rajnak K. Electronic Energy Levels in the Trivalent Lanthanide Aquo Ions. I. Pr3+, Nd3+, Pm3+, Sm3+, Dy3+, Ho3+, Er3+, and Tm3+, J. Chem. Phys.1968; 49: 4424.
Yaiphaba N. Comparative 4f–4f absorption spectral study for the interactions of Pr(III) with selected urea and thiourea: Energy and electric dipole intensity parameters. Journal of Chemical and Pharmaceutical Research. 2013; 5(10): 377-385.
Victory C.D, Singh N.R. Calculation of Energy Interaction and Electric Dipole Intensity Parameters to Explore the Interaction between the TrivalentPraseodymium and Uracil Using 4f-4f Transition Spectra as anAbsorption Probe. International Conference on Chemistry and Chemical Process IPCBEE .2011; 10.
Qusti A.H, Sehemi A.G.M. Spectral studies of Pr3+ in different solvents. J. KAU Sci. 1995; 7: 57-65.
Vyas M, Vyas A, Maheshwari R, Pandey H.K. Characterization of Some Er (III) Systems In Terms of Electronic-Spectral Parameters. Ultra Chemistry. 2012; 8(2): 189-194.
Schmidtke H.H. The Variation of Slater-Condon Parameters Fk and Racah Parameters B and C with Chemical Bonding in Transition Group Complexes, Structure and Bonding. 2004; 106: 19– 35.
Sharma Y.K, Singh R.K, Pal S. Praseodymium Ion Doped Sodium Borosilicate Glasses: Energy Interaction and Radiative Properties. American Journal of Condensed Matter Physics. 2015; 5(1): 10-18.
Selvaraj K, Theivarasu C. Thermal and Spectroscopic Studies of Terbium(Iii) and Dysprosium(Iii) Complexes with Piperidin-4-Ones. Thermochim. Acta. 2003; 401: 187–197.
Singh R.V, Mitharwal P, Singh R, Mital S.P. Synthesis, Characterization, Spectral (FT-IR, 1H, 13C NMR, Mass and UV) and Biological Aspects of the Coordination Complexes of Sulfur Donor Ligands with Some Rare Earth Elements. Am. Chem. Sci. J. 2014; 4: 117-137.
Singh T.D, Sumitra C.H, Devi N.I, Singh N.R. Spectral study of the complexation of Nd(III) with glutathione reduced (GSH) in the presence and absence of Zn(II) in aquated organic solvents. J. Chem. Sci. 2004; 116(6): 303.
Devi H. Debecca, Sumitra Ch., Singh T. D, Yaiphaba N, Singh N.M, Singh N. R. Calculation and Comparison of Energy Interaction and Intensity Parameters for the Interaction of Nd(III) with DL-Valine, DL-Alanine and β-Alanine in Presence and Absence of Ca2+/Zn2+ in Aqueous and Different Aquated Organic SolventsUsing 4f-4f Transition Spectra as Probe. Int J Spectrosc. 2009; Article ID 784305: 1-9. DOI: https://doi.org/10.1155/2009/784305
Keshavan B, Radhika R.T. Synthesis, Characterization and Antibacterial Activity of Complexes of Lanthanide(III) Nitrates with 2-Chloro-10-[3-(Diethylamino)Propyl]-Phenothiazine. Synth.React. Inorg. Met.-Org. Chem. 1999; 29: 1339-1352.
Mutalik V, Phaniband M. A. Synthesis, characterization, fluorescent and antimicrobial properties of new Lanthanide(III) complexes derived from coumarin Schiff base. J. Chem. Pharm. Res. 2011; 3: 313-330.
Al MomaniW.M. Antibacterial activity of lanthanides complexes with N, N'-bis(2-hydroxy-1- naphthylidene)-1, 6-hexadiimine. Asian J. Biochem. Pharm. Res. 2013; 3: 29-36.
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