• Filka G. Georgieva Department of Dermatology and Venerology, Medical University Varna, Bulgaria
Keywords: Sensitive Skin Syndrome, Trigger Factors, Endocrine Disruptors


Background: Sensitive Skin Syndrome (SSS) is predominantly a self-defined condition without an objective pathological finding. The syndrome presents with sudden and easily provoked flushes accompanied by unpleasant sensations like itching, pain, numbness in response to stimuli that usually do not cause such sensations. Endocrine disruption (ED) is an exogenous substance or mixture that induce negative health problems through affecting function(s) of the endocrine system in an intact organism. The Aim of The Study: was to establish the role of ED as a causative agent in SSS. Objective and Methods: The presented study includes 304 female self-diagnosed with SSS. Demographic data were collected from registers of Medico-Aesthetic Center “Medea” Varna from April 2017 till April 2019. The model of the study investigates the causes of SSS. Results: Results show the overall frequency of SSS was 31, 97%. As 174 (57, 23%) diagnosed in aesthetic visitors and 130 (42, 77%) in those with some health problem. The distribution according to the trigger factor show the prevalence of cosmetic products -56, 90%, detergents 21.05% and cosmetic procedures- 40, 88%. Conclusion: SSS is a serious health problem. The data from our study show that trigger factors, which are closely connected with EDC have a significant impact on this syndrome. In addition, adding topical treatment worsen rather than improve SSS. The literature sources reveal that this is first study of the role of ED as a causative agent in SSS in our country. 


Download data is not yet available.


Misery l, Stander S, Szepietowski JC, et al. Definition of Sensitive Skin: An Expert Position Paper from the Special Interest Group on Sensitive Skin of the International Forum for the Study of Itch. Acta Dermato Venereologica .2017; 97(1),1-3.

Maibach HI. The cosmetic intolerance syndrome. Ear Nose Throat J. 1987; 66,29-33.

Fisher AA. Cutis. "Status cosmeticus": a cosmetic intolerance syndrome. Cutis. 1990; 46,109-110.

Taieb C, Auges M, Georgescu V, Perez Cullell N, Miséry L. Sensitive skin in Brazil and Russia: an epidemiological and comparative approach. Eur J Dermatol. 2014; 24,372-376 DOI:

Willis CM, Shaw S, De Lacharrière O, Baverel M, Reiche L, Jourdain R, et al. Sensitive skin: an epidemiological study. Br J Dermatol. 2001; 145,258-263.

Berardesca E, Farage M, Maibach H. Sensitive skin: an overview. Int J Cosmet Sci. 2013; 35,2-8.

Lev-Tov H, Maibach HI. The sensitive skin syndrome. Indian J Dermatol. 2012; 57(6),419-423.

Christos C Z. The skin as an endocrine organ. Dermatoendocrinol. 2009; 1(5): 250–252. DOI:

Misery L. Jean-Decoster C. Sophie Sophie M. Sibaud V. A New Ten-Item Questionnaire for Assessing Sensitive Skin: The Sensitive Scale-10. Acta Derm Venereol 2014; 94,635–639 DOI:

Duarte I, Silveira JEPS, Hafner MFS, Toyota R, Pedroso DMM. Sensitive skin: review of an ascending concept. An Bras Dermatol. 2017; 92(4), 521-525.

Misery L, Myon E, Martin N, Consoli S, Boussetta S, Nocera T, Taieb C. Sensitive skin: psychological effects and seasonal changes. J Eur Acad Dermatol Venereol. 2007; 21(5), 620-8.

Misery L, Myon E, Martin N, Verriere F, Nocera T, Taied C. Sensitive skin in France: an epidemiological approach. Ann Dermatol Venereol 2005; 132(5), 425-9 DOI:

Hadar Lev-Tov, Howard I Maibach. The Sensitive Skin Syndrome. Indian J Dermatol. 2012; 57(6), 419–423.

Emilie Brenaut, Laurent Misery, Charles Taieb. Sensitive Skin in the Indian Population: An Epidemiological Approach. Front. Med., 2019; 6, 29 DOI:

SotiriosMaipasPolyxeni. Nicolopoulou-StamatiEmail. Sun lotion chemicals as endocrine disruptors. Hormones 2015; 14 (1), 32–46 DOI:

Caliman F A. Maria Gavrilescu. Pharmaceuticals, Personal Care Products and Endocrine Disrupting Agents in the Environment – A Review. CLEAN; 2009; 37, (4‐5), 277-303 DOI:

V. Godoy, M.A. Martín-Lara, M. Calero and G. Blázquez, Physical-chemical characterization of microplastics present in some exfoliating products from Spain, Marine Pollution Bulletin, 2019; 139, 91-99 DOI:

Vanderford B J., Pearson A., Rexing D J., Snyder S A. Analysis of Endocrine Disruptors, Pharmaceuticals, and Personal Care Products in Water Using Liquid Chromatography/Tandem Mass Spectrometry. Anal. Chem.2003; 75, 6265-6274 DOI:

EvanthiaDiamanti-Kandarakis, Jean-Pierre Bourguignon, Linda C. Giudice, Russ Hauser, Gail S. Prins, Ana M. Soto, R. Thomas Zoeller, Andrea C. Gore. Endocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement. Endocr Rev. 2009; 30(4), 293–342.

Patel, S. Fragrance compounds: The wolves in sheep’s clothings. Med. Hypotheses 2017; 102, 106– 111 DOI:

Ripamonti E, Allifranchini E, Todeschi, S Bocchietto E. Endocrine Disruption by Mixtures in Topical Consumer Products. Cosmetics 2018; 5(4), 61 DOI:

MacIsaac, J.K.; Gerona, R.R.; Blanc, P.D.; Apatira, L.; Friesen, M.W.; Coppolino, M.; Janssen, S. Healthcare Worker Exposures to the Antibacterial Agent Triclosan. J. Occup. Environ. Med. 2015; 56, 834–839.

Frederiksen, H.; Nielsen, O.; Skakkebaek, N.E.; Juul, A.; Andersson, A.M. UV filters analyzed by isotope diluted TurboFlow-LC-MS/MS in urine from Danish children and adolescents. Int. J.Hyg. Environ. Health 2017; 220, 244–253. DOI:

Ota, Y.; Imai, T.; Onose, J.; Takami, S.; Cho, Y.M.; Hirose, M.; Nishikawa, A. A 55-week chronic toxicity study of dietary administered kojic acid (KA) in male F344 rats. J. Toxicol. Sci. 2009; 34, 305–313.

How to Cite
Georgieva, F. (2019). SENSITIVE SKIN SYNDROME AND ENDOCRINE DISRUPTORS - IS THERE A CONNECTION? . International Journal of Engineering Technologies and Management Research, 6(9), 62-67.