OCCURRENCE OF ELEPHANTIASIS IN NANDURBAR DISTRICT, OF (M.S), INDIA

Elephantiasis is caused by parasite Wuchereria bancrofti transmitted through the bites of Culex pipiens, C. quinquefaciatus, C. fatigans, B.malayi, Aedes niveus in Andaman and Nicobar islands.mosquitoes. Diseased organisms body transmits the Wuchereria bancrofti to healthy person. Elephantiasis is also known as Filariasis.


INTRODUCTION
As the elephantiasis is like a leg of elephant appearance. Hence is called elephantiasis and as it is caused by Wuchereria is also known as Wuchereriasis disease. It is very prevalent in Navapur Tahsil as climate of this area is very favourable for the development of Culex pipiens, C. quinquefaciatus, species. Such outbreak of Filariasis was also recorded bye in Navapur tahsil near Chinchapada village, is SAVRAT, BK and Savrat Khurd, under P. H. C. Dr. Vasave was working in Chinchapada village (2004)(2005). And Prakasha P. H. C. also reported the patients during the same year of Shahada Tahsil. As the people are also illiterate in this tribal area. Rice-fields as well as rain is more, improperdrainage system or poor-sanitation, living in houses made traditionally, they do not take part in discussion with people of other place, they fear to other people besides Maharashtra District cases were also reported from other states of India In Maharashtra, there are 17 districts of Filariasis worm disease like, Akola, Amravati, Bhandara, Chandrapur, Gadchiroli, Gondia, Jalgaon, Latur, Nagpur, Nanded, Nandurbar, Osmanabad, Shindhudurg,, Solapur, Thane, Wardha, and Yavatmal. (2017)  Those in the US who have the disease, which is spread by mosquitoes that carry baby worms, / infected while travelling abroad. This leads to dysfunction of the lymph system causing swelling in the limbs known as Lymphedema. Hardening of the arms and legs is called as Elephantiasis. Swelling of scrotum in men is called as Hydrocele.
Lymphatic Filariasis is leading cause of permanent disability worldwide as reported by the survey by the Centers for Disease Control and Prevention.
Filariasis is caused by infection with round worm. Wuchereria-bancrofti, through the bite of infected blood sucking black-flies and mosquito Culex pipiens. ,C.quinquefaciatus.species., C. fatigans.
B. malayi is transmitted by Mansonia mosquitoes and is restricted to South and South East Asia. It is one of the tropical disease targeted for the elimination by the year 2020 declared by WHO. Human filarial nematode worm have the complicated life cycle, which primarily consists of 5-stages. After the male and female worms mate, the female gives birth to live Microfilariae by the thousands. The Microfilariae are taken by the vector insect called as INTERMEDIATE Host during a blood meals, the insect vector such, Culex pipiens species injects the infectious larvae into the dermis layer of skin. After about one year, the larvae molt through the moulting stages, maturing into adult worms Mansonia perstans.
C. quinquefaciatus has been the most predominantly contribute 99.4% infection in India. Aedes niveus is causing lymphatic Filariasis in Andaman and Nicobar Islands (17, June, 2017).

STUDY AREA
Nandurbar district is the North West corner of Maharashtra State of India. On 1 June 1998, Dhule district was bifurcated and Nandurbar district is formed. It have 5035km² area. It is bounded to South and South East by Dhule district. To the West and North is the state Gujarat, To the North and North East is the Madhya Pradesh. Northern boundary is defined by Narmada River.
By taking databases from Primary Health Centres (PHC), reports (from2004-2005), Malaria officer, as well as District Health Officers collected in December in Navapur Tahsil as well as Rural areas during 14-16 December (2015). Globally, 120 million people are infected by Filariasis, in India more than 5000 people are infected with Filariasis every year. Causing more economic losses to people of globe.

DISCUSSION
As the Navapur Tahsil is disease prone zone of elephantiasis. District Health Officers (DHO) of Navapur and Nandurbar District organised a campaign for prevention of elephantiasis. They distributed the medicines to the people of Navapur Tahsil. Because in Nandurbar District 26 cases were found positive. And 118 (-ve) cases were record with results in check up. In Navapur Tahsil 13 patients are noticed by (DHO). For prevention of elephantiasis different drugs were given to people in Navapur Tahsil whole Nandurbar District.,like albendazole and DEC(DiEthylCarbamazine) tablets. These tablets prevent elephantiasis if people suffering from elephantiasis and transmitter of elephantiasis take this regularly. Therefore, each and every suffering from elephantiasis.

TREND AND PRESENT SCENARIO
In India, it is estimated to be over 250 district, and 20 States putting 650 million people at risk. In India, 99.4% cases caused by the W. bancrofi and 0.6% by B. malayi (17, Nov. 2017). About 5 crore people in India and 40% people in globe carrying infections. Treatment is given to 40 crore people in India. Dr. Harshavardhan, told 2021 is eradication year for lymphatic Filariasis. States of Bihar over 17%, Kerala 15.7%, U. P. 14.6%, T. N. 10%, Assam 5%, M. P. 3%, and Goa less than 1%, lymphatic Filariasis.
Such out break also occur in Andhrapradesh, 25/5/2020, Chief Minister of the A. P., Y.S.Jagan Mohan Reddy, discussed the situation and people are provided with proper medical care facility.
In India, such recently available record, but WHO, decided to control and eradicate Filariasis upto year, 2020. In 2015, about 38.5 million people were infected, about 950 million people were at the risk of Filariasis in 54 countries. It is the most common in tropical Africa and Asia. It causes economic losses of billions of dollars per year.
In 2015, WilliamC. Campbell and Santoshi Omura awarded Nobel Prize for drug in Filariasis in Physiology/Medicine drug ivemectia.

CARE OF ELEPHANTIASIS PATIENTS
Patients are given instructions that, Albendazole and DEC tablets prevents elephantiasis.
1) But these tables should be taken only one time at noon or night after dinner.
2) From DHO chemical or drugs are given to PHC hospitals.
3) Trainings are given to people as well as campaigns are arranged in school and colleges regarding prevention of elephantiasis in Navapur Tahsil during December and January (2015-2016). 4) Meetings were held and information was given to people about elephantiasis. According to a New technology for treatment was recently developed in United States. A Genomic Research University of Maryland (December, 5,2019), Using innovative RNA sequencing technique, lymphatic Filariasis, a disabling parasitic disease that, therapy is an experimental cancer drug called JQ1 and target proteins found prominently in the worm's genome and kills the adult worms in a laboratory setting. According to study, a tropical parasitic disease that affects the lymph nodes and lymph vessels. As lymphatic Filariasis is a leading cause of permanent disability globally. According to the Centers for Disease Control and Prevention (5, December,2019).
"The drug JQ1 works by inhibiting bromodomain containing proteins that are necessary for the adult worms to live ", Said Study Author Julie Dunning Hotopp, Ph. D., Professor of Microbiology and Immunology, Institute of Genome Sciences, University of Maryland, School of Medicine, Novel Therapeutic leads to Lymphatic Filariasis Guided by Multispecies Transcriptomics. mSystems DOI.

NECESSARY ACTIONS
1) People should be made prepared for fighting against Filariasis. 2) Schools and Colleges must be prepared for awareness among the Filariasis and other insect borne and other diseases. 3) People must be aware of their own personal cleanliness and better living practices. It will prevent to growth of Mosquito and other insects. 4) People must be educated with spraying oil/ kerosene over ditches around surrounded dirty areas for preventing growth of weeds. 5) Use house clean and window and doors screening should be done for prevention of mosquito bite. 6) Various awareness programme about different disaster/ calamities of diseases should be avoided by showing Audio-visuals to the people who are illiterate. 7) Use of mosquito-nets against the disease/mosquito bite. 8) Tablets were given to the patients from curing different epidemic and endemic diseases. 9) People survey for different season episode of different disease outbreak. 10) It is very useful for avoiding spread of disease. 11) Awareness Campaign are held for prevention and Control of the disease. 12) Meetings and Social worker, Health Worker information helps the people to cure diseases.

OBSERVATION AND RESULTS
Tahsil of Nandirbar district and the Number of elephantiasis patients positive (+ve), and negative. (-ve) are shown in the following 1)Culex pipiens, C. fatigans, C. quinquefaciatus are endemic species are one enemies of man causing elephantiasis disease so its control is very essential. India, contributes 41% of global lymphatic Filariasis. (1997). So it is very important to control this disease. 2.) Awareness among the people, among, society, in Schools, Colleges levels should be done for eradication of Filariasis disease from various parts of globe.

SOURCES OF FUNDING
None.