TO INVESTIGATE CELL VIABILITY, CYTOTOXICITY AND ANTI-CANCEROUS PROPERTIES OF PHYLLANTHUS EMBLICA EXTRACT ON HUH-7 AND L929 CELL LINES
DOI:
https://doi.org/10.29121/shodhkosh.v5.i2.2024.5137Keywords:
Extracellular Matrix, Huh 7 Cell Line, L929 Cell Line, Hepatocellular Carcinoma, Phyllanthus Emblica, CytotoxicityAbstract [English]
Phyllanthus emblica commonly known as Indian gooseberry or amla, has been widely recognized for its medicinal properties, including its potential anticancer effects. This study investigates its impact on Huh-7 liver cancer cells and L929 normal fibroblast cells by evaluating cell viability, cytotoxicity and oxidative stress. The MTT assay was used to assess cell viability, revealing a dose-dependent decrease in cancer cell survival while sparing normal cells. Reactive oxygen species (ROS) analysis indicated increased oxidative stress in Huh-7 cells, suggesting a role in apoptosis induction. These findings suggest that P. emblica selectively targets cancer cells while causing minimal harm to normal cells, making it a promising candidate for natural anticancer therapies. However, further studies are needed to explore its molecular mechanisms and in vivo efficacy.
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